Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sudha Korwar"'
Autor:
Benjamin L. Morris, Dipankar Bandyopadhyay, Zaid Nawaz, Sudha Korwar, Priyadarshan K Damle, Sahib J. Singh, Francisco Zarate-Perez, Carlos Escalante, Michael J Dennis, Xiaoyan Deng, M. Michael Dcona, Keith C Ellis, William E. Royer, Steven R. Grossman
Publikováno v:
Mol Pharmacol
C-terminal binding proteins (CtBP1/2) are oncogenic transcriptional coregulators and dehydrogenases often overexpressed in multiple solid tumors, including breast, colon, and ovarian cancer, and associated with poor survival. CtBPs act by repressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57ac73f5f618f55277ce3da631760f3
https://doi.org/10.1124/mol.118.114363
https://doi.org/10.1124/mol.118.114363
Autor:
Sudha Korwar, Thomas D. Roper, Caleb J. Kong, B. Frank Gupton, Saeed Ahmad, Swara Fadnis, Nakul Telang, Somi Amir, Bimbisar Desai, Perrer N. Tosso
Publikováno v:
European Journal of Organic Chemistry. 2017:6495-6498
The application of continuous methods in the synthesis of active pharmaceutical ingredients continues to receive significant attention in the academic as well as the industrial research communities. One of the major advantages of continuous methods i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d7862be28f173c348c88cf950732864
https://doi.org/10.1002/ejoc.201701002
https://doi.org/10.1002/ejoc.201701002
Autor:
Brendan J. Hilbert, Robert A. Coover, William E. Royer, Tyler W. Doughty, Glen E. Kellogg, Sudha Korwar, Keith C. Ellis, Ian M. Love, Benjamin L. Morris, Steven R. Grossman, Hardik I. Parikh
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2707-2715
C-terminal Binding Protein (CtBP) is a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes. Utilizing a crystal structure of CtBP with its substrate 4-methylthio-2-oxobutyric acid (MTOB) and NAD+ as a guide,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c03beda637ff225d770b79b990edbc9
https://doi.org/10.1016/j.bmc.2016.04.037
https://doi.org/10.1016/j.bmc.2016.04.037
Autor:
Kendra W. Brinkley, Stanley E. Gilliland, Sudha Korwar, Michael Burkholder, Keith C. Ellis, B. Frank Gupton
Publikováno v:
Chemical communications (Cambridge, England). 53(52)
Chelation-directed C–H activation/C–C bond forming reactions utilizing homogeneous palladium(II) and the Pd(II)/Pd(IV) catalytic cycle have been previously reported. Here we report the first use of a solid-supported Pd(II) catalyst [Pd(II) nanopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1961edb1aca58a417c869d3c8fb0c7de
https://pubmed.ncbi.nlm.nih.gov/28613290
https://pubmed.ncbi.nlm.nih.gov/28613290
Autor:
Robert A. Coover, Charles E. Lyons, Sudha Korwar, Nicole M. Luzi, Darrell L. Peterson, Keith C. Ellis, Maria E. Casile
Publikováno v:
Organicbiomolecular chemistry. 14(20)
The design and development of irreversible kinase inhibitors is an expanding frontier of kinase drug discovery. The current approach to develop these inhibitors utilizes ATP-competitive inhibitor scaffolds to target non-catalytic cysteines in the kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7cfd68e1b84670857c7da7fbe520ee
https://pubmed.ncbi.nlm.nih.gov/27126273
https://pubmed.ncbi.nlm.nih.gov/27126273
Publikováno v:
ChemInform. 46
The title catalyst efficiently promotes C—H activation reactions to allow the transformation of C—H to C—O, C—Cl, and C—Br bonds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1faf6c920d7d5134c7296fd089d49cc
https://doi.org/10.1002/chin.201533029
https://doi.org/10.1002/chin.201533029
Publikováno v:
Organic letters. 17(7)
N-Chelation-directed C–H activation reactions that utilize the Pd(II)/Pd(IV) catalytic cycle have been previously reported. To date, these reactions employ only homogeneous palladium catalysts. The first use of a solid-supported Pd(II) catalyst [Pd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f351925da4b8386e3a0ba4de71b8f6fa
https://pubmed.ncbi.nlm.nih.gov/25789562
https://pubmed.ncbi.nlm.nih.gov/25789562
Preparation and evaluation of deconstruction analogues of 7-deoxykalafungin as AKT kinase inhibitors
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(1)
The pyranonaphthoquinone (PNQ) lactone natural products, including 7-deoxykalafungin, have been reported to be potent and selective covalent inhibitors of AKT kinase. In this work we seek to identify structural features of the natural product scaffol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959c6f006027d5d45529f13acc613179
https://pubmed.ncbi.nlm.nih.gov/24321345
https://pubmed.ncbi.nlm.nih.gov/24321345
Autor:
Evan T. Sumner, Steven R. Grossman, Benjamin L. Morris, Brendan J. Hilbert, Keith C. Ellis, M. Michael Dcona, William E. Royer, Sudha Korwar
Publikováno v:
Cancer Research. 76:2003-2003
C-terminal binding proteins 1 and 2 (CtBP) are transcriptional coregulators whose overexpression has been linked to poor prognosis and/or chemoresistance in most common solid tumor types. CtBP exerts oncogenic activities through modulation of gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c68f3f092f821c271c9ab4d22088ea19
https://doi.org/10.1158/1538-7445.am2016-2003
https://doi.org/10.1158/1538-7445.am2016-2003