3D-QSAR, Pharmacophore Modeling, ADMET, and DFT Studies of Halogenated Conjugated Dienones as Potent MAO-B Inhibitors.

Autor: Mathew GE; Department of Pharmacology, Lisie College of Pharmacy, Vennala, 682028, Kerala, India; Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be a University), Salem, 636308, Tamilnadu, India, Herrera-Acevedo C; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, 58051-900, João Pessoa, Brazil, Scotti MT; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, 58051-900, João Pessoa, Brazil, Kumar S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India, Berisha A; Department of Chemistry, Faculty of Natural and Mathematics Science, University of Prishtina, 10000, Prishtina, Kosovo, Kaya S; Department of Pharmacy Health Services Vocational School, Sivas Cumhuriyet University, 58140, Sivas Turkey, Alfarraj S; Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia, Ansari MJ; Department of Botany, Hindu College Moradabad (Mahatma Jyotiba Phule Rohilkhand University Bareilly), 244001, India, Dhyani A; School of Pharmacy, Graphic Era Hill University, Dehradun, 248007, India, Sudevan ST; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India, Kumar M; Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be a University), Salem, 636308, Tamilnadu, India, Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India

Publikováno v: Current computer-aided drug design [Curr Comput Aided Drug Des] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.

A Comprehensive Review of the Docking Studies of Chalcone for the Development of Selective MAO-B Inhibitors.

Autor: Krishna A; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682 041, India., Kumar S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682 041, India., Sudevan ST; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682 041, India., Singh AK; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682 041, India., Pappachen LK; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682 041, India., Rangarajan TM; Department of Chemistry, Sri Venketeswara College, University of Delhi, New Delhi-110021, India., Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Al Jouf 72341, Saudi Arabia., Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi-682 041, India.

Publikováno v: CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2024; Vol. 23 (6), pp. 697-714.

Inhibiting Monoamine Oxidase in CNS and CVS would be a Promising Approach to Mitigating Cardiovascular Complications in Neurodegenerative Disorders.

Autor: Srivastava P; Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, 682 041, Kerala, India., Sudevan ST; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India., Thennavan A; Central Lab Animal Facility, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, 682 041, Kerala, India., Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India., Kanthlal SK; Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, 682 041, Kerala, India.

Publikováno v: CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2024; Vol. 23 (3), pp. 331-341.

Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular dynamics study.

Autor: Thomas Parambi DG; College of Pharmacy, Department of Pharmaceutical Chemistry, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia. Electronic address: dellajesto@ju.edu.sa., Oh JM; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea., Kumar S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India., Sudevan ST; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India., Hendawy OM; College of Pharmacy, Department of Clinical Pharmacology, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia., Abdelgawad MA; College of Pharmacy, Department of Pharmaceutical Chemistry, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia., Musa A; College of Pharmacy, Department of Pharmacognosy, Jouf University, Sakaka, 72341, Al Jouf, Saudi Arabia., Al-Sanea MM; College of Pharmacy, Department of Pharmaceutical Chemistry, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia., Ahmad I; Department of Pharmaceutical Chemistry, Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule 424002, Maharashtra, India., Patel H; Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, Maharashtra, India., Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea. Electronic address: hoon@sunchon.ac.kr., Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India. Electronic address: bijovilaventgu@gmail.com.

Publikováno v: Computational biology and chemistry [Comput Biol Chem] 2023 Aug; Vol. 105, pp. 107899. Date of Electronic Publication: 2023 Jun 01.

Review of β-carboline and its derivatives as selective MAO-A inhibitors.

Autor: Benny F; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India., Kumar S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India., Jayan J; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India., Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., Ghoneim MM; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia., Kumar A; School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, India., Manoharan A; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India., Susan R; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India., Sudevan ST; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India., Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, India.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2023 Jul; Vol. 356 (7), pp. e2300091. Date of Electronic Publication: 2023 Apr 06.