Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sudeep Pushpakom"'
Autor:
Sudeep Pushpakom, Ruwanthi Kolamunnage-Dona, Claire Taylor, Terry Foster, Catherine Spowart, Marta Garcia-Finana, Graham J Kemp, Thomas Jaki, Saye Khoo, Paula Williamson, Munir Pirmohamed
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 6, Iss 6 (2019)
Background: Combination antiretroviral therapy (cART) is the standard for human immunodeficiency virus (HIV) infection treatment but can result in metabolic abnormalities, such as insulin resistance, dyslipidaemia and lipodystrophy, which can increas
Externí odkaz:
https://doaj.org/article/d8e48ba2ac624feebe41e795e55bbf8a
Autor:
Andrea L. Jorgensen, Innocent G Asiimwe, Ruwanthi Kolamunnage-Dona, Richard M. Turner, Sudeep Pushpakom, Munir Pirmohamed
Publikováno v:
British Journal of Clinical Pharmacology
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
OBJECTIVETo continually evaluate the rapidly evolving evidence base on the role of cardiovascular drugs in COVID-19 clinical outcomes (susceptibility to infection, hospitalization, hospitalization length, disease severity, and all-cause mortality).DE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbedad089cc4060b0426fa1105913865
http://europepmc.org/articles/PMC8239929
http://europepmc.org/articles/PMC8239929
Autor:
Paula R Williamson, Ruwanthi Kolamunnage-Dona, Claire Taylor, Saye Khoo, Graham J. Kemp, Munir Pirmohamed, Terry Foster, Thomas Jaki, Sudeep Pushpakom, Cath Spowart, Marta García-Fiñana
Publikováno v:
Clinical Infectious Diseases
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background Combination antiretroviral therapy results in metabolic abnormalities which increase cardiovascular disease risk. We evaluated whether telmisartan reduces insulin resistance in human immunodeficiency virus (HIV)–positive individuals on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c97877c2e793afd5187bb097f63548
Autor:
Munir Pirmohamed, David Cavalla, Andrew D. Wells, Andrew J. Doig, Philippe Sanseau, Tim Guilliams, Francesco Iorio, Christine J. McNamee, Sudeep Pushpakom, K. Jane Escott, Joanna Latimer, Shirley Hopper, Patrick A. Eyers, Alan Norris
Publikováno v:
NATURE REVIEWS DRUG DISCOVERY
Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821d3e357a2d91fb1cfb7090bc94e339
https://pubmed.ncbi.nlm.nih.gov/30310233
https://pubmed.ncbi.nlm.nih.gov/30310233
Autor:
Soban, Sadiq, Euan, Owen, Terry, Foster, Katy, Knight, Lihui, Wang, Munir, Pirmohamed, Richard E, Clark, Sudeep, Pushpakom
Publikováno v:
Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e159923ed5fecdaa67afa7400eb3ca9
https://pubmed.ncbi.nlm.nih.gov/30692595
https://pubmed.ncbi.nlm.nih.gov/30692595
Autor:
Antonysunil Adaikalakoteswari, Sudhesh Kumar, Philip G. McTernan, David Back, Sudeep Pushpakom, Andrew Owen, Gyanendra Tripathi, Munir Pirmohamed
Publikováno v:
Diabetes & Vascular Disease Research
Diabetes & vascular disease research
Diabetes & vascular disease research
Background:Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose–resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5a67ffc5459ae2ec31244eaa17dd25
http://wrap.warwick.ac.uk/99438/7/WRAP-telmisartan-reserves-antiretroviral-induced-adipocyte-toxicity-insulin-resistance-in-vitro-Kumar-2018.pdf
http://wrap.warwick.ac.uk/99438/7/WRAP-telmisartan-reserves-antiretroviral-induced-adipocyte-toxicity-insulin-resistance-in-vitro-Kumar-2018.pdf
Publikováno v:
Pharmacology & Therapeutics. 153:10-24
Alcohol dependence is a common disorder in many societies worldwide, and remains difficult to identify and treat. It is also a risk factor for many secondary non-communicable diseases. Pharmacotherapy is one available treatment option, but appears to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768c8b0d6f592f7777c0e196495b97c7
https://doi.org/10.1016/j.pharmthera.2015.05.010
https://doi.org/10.1016/j.pharmthera.2015.05.010
Publikováno v:
Pharmacogenetics and Genomics. 23:438-441
HIV lipodystrophy (HIVLD), associated with combination antiretroviral therapy (cART), leads to metabolic and cardiovascular diseases. Nuclear receptors play a central role in lipid homoeostasis and drug disposition; their genetic variants may predisp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda3fb1ffd959ec4780b91b9eb766327
https://doi.org/10.1097/fpc.0b013e328362cfc6
https://doi.org/10.1097/fpc.0b013e328362cfc6
Autor:
Triantafilos Liloglou, Tessa L. Holyoake, Munir Pirmohamed, George Xinarianos, Sudeep Pushpakom, Jieying-Eunice Zhang, Richard E. Clark, Letizia Foroni, Lihui Wang, Gemma Austin, Andrea L. Jorgensen, Martin C. Müller, Andrea Davies, Athina Giannoudis, Panagiotis D. Kottaridis
Publikováno v:
Blood. 121:628-637
Although the prognosis of chronic myeloid leukemia (CML) patients treated with imatinib is good, many fail to develop an optimal response or lose one. This heterogeneity could be attributed to the presence of human organic cation transporter-1 (hOCT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6216b2ba39945c0af0165565cfef3db
https://doi.org/10.1182/blood-2012-01-405035
https://doi.org/10.1182/blood-2012-01-405035
Autor:
José Moltó, Marta Valle, Bonaventura Clotet, George Xinarianos, Cristina Miranda, Samandhy Cedeño, Andrew Owen, Sudeep Pushpakom
Publikováno v:
Clinical Pharmacokinetics; Vol 52
CLINICAL PHARMACOKINETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
CLINICAL PHARMACOKINETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Darunavir is a potent protease inhibitor of HIV. To enhance its pharmacokinetic profile, darunavir must be co-administered with ritonavir. There is wide inter-patient variability in darunavir pharmacokinetics among HIV-infected individuals, however.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf8bd9f6a8110ffb5f529352a15c564