Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes.

Autor: Weekman EM; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA. eweekman@iu.edu.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. eweekman@iu.edu., Johnson SN; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Rogers CB; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA., Sudduth TL; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA., Xie K; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA., Qiao Q; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA., Fardo DW; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA., Bottiglieri T; Center of Metabolomics, Institute of Metabolic Disease, Baylor Scott and White Research Institute, Dallas, TX, 75204, USA., Wilcock DM; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2023 Sep 01; Vol. 20 (1), pp. 199. Date of Electronic Publication: 2023 Sep 01.

Plasma TDP-43 levels are associated with neuroimaging measures of brain structure in limbic regions.

Autor: Bauer CE; Department of Neuroscience University of Kentucky Lexington Kentucky USA., Zachariou V; Department of Neuroscience University of Kentucky Lexington Kentucky USA., Sudduth TL; Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA., Van Eldik LJ; Department of Neuroscience University of Kentucky Lexington Kentucky USA.; Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA., Jicha GA; Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA.; Department of Neurology University of Kentucky Lexington Kentucky USA., Nelson PT; Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA.; Department of Pathology and Laboratory Medicine University of Kentucky Lexington Kentucky USA., Wilcock DM; Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA.; Department of Physiology University of Kentucky Lexington Kentucky USA., Gold BT; Department of Neuroscience University of Kentucky Lexington Kentucky USA.; Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA.; Department of Radiology University of Kentucky Lexington Kentucky USA.; Magnetic Resonance Imaging and Spectroscopy Center University of Kentucky Lexington Kentucky USA.

Publikováno v: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2023 May 31; Vol. 15 (2), pp. e12437. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).

Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort.

Autor: Winder Z; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.; Departments of Physiology, University of Kentucky, Lexington, Kentucky, USA., Sudduth TL; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA., Anderson S; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA., Patel E; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA., Neltner J; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.; Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA., Martin BJ; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA., Snyder KE; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA., Abner EL; Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA., Jicha GA; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.; Neurology, College of Public Health, University of Kentucky, Lexington, Kentucky, USA., Nelson PT; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.; Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA., Wilcock DM; Sanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.; Departments of Physiology, University of Kentucky, Lexington, Kentucky, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jan; Vol. 19 (1), pp. 67-78. Date of Electronic Publication: 2022 Mar 10.

Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT).

Autor: Pajewski NM; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Elahi FM; Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA., Tamura MK; Geriatric Research, Education and Clinical Center, Palo Alto Veterans Affairs Health Care System, California and Division of Nephrology, Stanford University School of Medicine, Palo Alto, California, USA., Hinman JD; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA., Nasrallah IM; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ix JH; Division of Nephrology-Hypertension, University of California San Diego, San Diego, California, USA., Miller LM; Division of Nephrology-Hypertension, University of California San Diego, San Diego, California, USA., Launer LJ; Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA., Wright CB; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA., Supiano MA; Geriatric Research, Education and Clinical Center, Veterans Affairs Salt Lake City Health System, Utah and Division of Geriatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA., Lerner AJ; Department of Neurology, University Hospitals-Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Sudduth TL; Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Killeen AA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Cheung AK; Renal Section, Veterans Affairs Salt Lake City Healthcare System, Utah and Division of Nephrology and Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA., Reboussin DM; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Wilcock DM; Department of Physiology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA., Williamson JD; Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Aug; Vol. 18 (8), pp. 1472-1483. Date of Electronic Publication: 2021 Nov 17.

Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults.

Autor: Gold BT; Department of Neuroscience, Sanders-Brown Center on Aging, Lexington, Kentucky, USA.; Sanders-Brown Center on Aging, Lexington, Kentucky, USA.; Magnetic Resonance Imaging and Spectroscopy Center, College of Medicine, University of Kentucky, Lexington, Kentucky, USA., Shao X; Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Sudduth TL; Sanders-Brown Center on Aging, Lexington, Kentucky, USA., Jicha GA; Sanders-Brown Center on Aging, Lexington, Kentucky, USA.; Department of Neurology, Sanders-Brown Center on Aging, Lexington, Kentucky, USA., Wilcock DM; Sanders-Brown Center on Aging, Lexington, Kentucky, USA.; Department of Physiology, Sanders-Brown Center on Aging, Lexington, Kentucky, USA., Seago ER; Department of Neuroscience, Sanders-Brown Center on Aging, Lexington, Kentucky, USA., Wang DJJ; Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Dec; Vol. 17 (12), pp. 2020-2029. Date of Electronic Publication: 2021 May 05.