Výsledky vyhledávání - "Sudarshana M. Sharma"

Akademický článek

A critical appraisal of ferroptosis in Alzheimer’s and Parkinson’s disease: new insights into emerging mechanisms and therapeutic targets

Autor: Priyanka Soni, Navneet Ammal Kaidery, Sudarshana M. Sharma, Irina Gazaryan, Sergey V. Nikulin, Dmitry M. Hushpulian, Bobby Thomas

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Neurodegenerative diseases represent a pressing global health challenge, and the identification of novel mechanisms underlying their pathogenesis is of utmost importance. Ferroptosis, a non-apoptotic form of regulated cell death characterized by iron

Externí odkaz: https://doaj.org/article/f038aea9e6284c14be3570e61d8fc184

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Akademický článek

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease

Autor: Manuj Ahuja, Navneet Ammal Kaidery, Debashis Dutta, Otis C. Attucks, Eliot H. Kazakov, Irina Gazaryan, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas

Publikováno v: Antioxidants, Vol 11, Iss 9, p 1780 (2022)

Parkinson’s disease (PD) is the second most common neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although a complex interplay of multiple environmental and gen

Externí odkaz: https://doaj.org/article/826cc5ab347d47988b76837e6681c0a4

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Akademický článek

Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation

Autor: Heather A. Carey, Blake E. Hildreth, III, Devadoss J. Samuvel, Katie A. Thies, Thomas J. Rosol, Ramiro E. Toribio, Julia F. Charles, Michael C. Ostrowski, Sudarshana M. Sharma

Publikováno v: iScience, Vol 11, Iss , Pp 238-245 (2019)

Summary: Bone-resorbing osteoclasts (OCs) are derived from myeloid precursors (MPs). Several transcription factors are implicated in OC differentiation and function; however, their hierarchical architecture and interplay are not well known. Analysis

Externí odkaz: https://doaj.org/article/4be868fa1ecd4874b54ecea31d64c241

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Akademický článek

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

Autor: Dmitry M. Hushpulian, Navneet Ammal Kaidery, Manuj Ahuja, Andrey A. Poloznikov, Sudarshana M. Sharma, Irina G. Gazaryan, Bobby Thomas

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)

The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential off-target effects and their impact on future drug development originating from Keap1-targeting smal

Externí odkaz: https://doaj.org/article/54d2b73ecbdc47da83d47b5c45340714

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Akademický článek

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug

Externí odkaz: https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195

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Akademický článek

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 9, Pp 541-552 (2016)

Preclinical studies have suggested that the pancreatic tumor microenvironment both inhibits and promotes tumor development and growth. Here we establish the role of stromal fibroblasts during acinar-to-ductal metaplasia (ADM), an initiating event in

Externí odkaz: https://doaj.org/article/f642c9d47f7143cd8fdecdebb309ab94

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