Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sudarshan Kapadnis"'
Autor:
Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, Richard Grater, Daniel Qiu, Sudarshan Kapadnis, Patrick Trapa
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Abstract Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method
Externí odkaz:
https://doaj.org/article/103f00bec9d940f988399c1ce77485f6
Autor:
Cheng Fang, Ye Wang, Richard Grater, Sudarshan Kapadnis, Cheryl Black, Patrick Trapa, Simone Sciabola
Publikováno v:
Journal of Chemical Information and Modeling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c671bb3f0d8fca384821c9438239de00
https://doi.org/10.1021/acs.jcim.3c00160
https://doi.org/10.1021/acs.jcim.3c00160
Publikováno v:
Intelligent Data Engineering and Analytics ISBN: 9789811666230
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c2ebb031b9e375c6855e70f7ca0127
https://doi.org/10.1007/978-981-16-6624-7_9
https://doi.org/10.1007/978-981-16-6624-7_9
Autor:
Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac
Publikováno v:
Journal of medicinal chemistry. 65(2)
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early stage of MS, inflammation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73da50c6f550d3e41002d416b5cebb6
https://pubmed.ncbi.nlm.nih.gov/34734694
https://pubmed.ncbi.nlm.nih.gov/34734694
Autor:
Deirdre Murphy, Sudarshan Kapadnis, Bryce Alden Harrison, Hilliary E Van Voorhies, Jean-Francois Blain, Emily A. Freeman, Jeffrey S. Moffit, Scott Nolan, Melody Wen, Lori Hrdlicka, Duane A. Burnett, Matthew Gregory Bursavich, Gerhard Koenig, Don Costa, Holger Patzke, Raksha A. Acharya, Cuyue Tang, Hong Jin
Publikováno v:
Journal of medicinal chemistry. 64(19)
The recent approval of aducanumab for Alzheimer's disease has heightened the interest in therapies targeting the amyloid hypothesis. Our research has focused on identification of novel compounds to improve amyloid processing by modulating gamma secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f9b0147cc5066edcb7f9badfeea7b3
https://pubmed.ncbi.nlm.nih.gov/34550687
https://pubmed.ncbi.nlm.nih.gov/34550687
Autor:
Sudarshan Kapadnis, Patrick Trapa, Richard Grater, Daniel Qiu, Taras Tuczewycz, Christopher Rowbottom, Alicia Pietrasiewicz
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a2ee10faed30def67aa2b2127bd820
http://europepmc.org/articles/PMC7931226
http://europepmc.org/articles/PMC7931226
Autor:
Alicia Pietrasiewicz, Taras Tuczkewycz, Sudarshan Kapadnis, Richard Grater, Christopher Rowbottom, Daniel Qiu, Doug Burdette, Elvana Viezaj
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f472d5a0170797247e4fe2e3cc05658
https://doi.org/10.1016/j.dmpk.2020.04.132
https://doi.org/10.1016/j.dmpk.2020.04.132
Autor:
Holger Patzke, Cuyue Tang, Gerhard Koenig, Hong Jin, Lori Hrdlicka, Duane A. Burnett, Sudarshan Kapadnis, Don Costa, Hilliary Hodgdon, Emily A. Freeman, Jean-Francois Blain, Jeffrey S. Moffit, Melody Wen, Bryce Alden Harrison, Matthew Gregory Bursavich, Raksha A. Acharya, Deirdre A. Murphy, Scott Nolan
Publikováno v:
Journal of medicinal chemistry. 60(6)
Herein we describe the design, synthesis, and evaluation of a novel series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and critical consideration of conformational restriction. Oxadiazine lead 47 possesses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9482321eb4d1ebfec5e8c96be975c48
https://pubmed.ncbi.nlm.nih.gov/28230986
https://pubmed.ncbi.nlm.nih.gov/28230986
Autor:
Deirdre Murphy, Ting Chen, Dorothy G. Flood, Gerhard Koenig, Devin Franklin Welty, Yi Tao, Xing Chen, Scott Nolan, Sudarshan Kapadnis, Don Costa, Melody Wen, Hilliary Hodgdon, Cuyue Tang
Publikováno v:
Biochemical Pharmacology. 91:543-551
Two investigational compounds (FRM-1, (R)-7-fluoro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and FRM-2, (R)-7-cyano-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide) resided in rat brain longer than in systemic circulation. In Caco-2 dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa77931e039a2c0a620ef685b98b22f
https://doi.org/10.1016/j.bcp.2014.07.023
https://doi.org/10.1016/j.bcp.2014.07.023
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22809c70199231ef2ba8d2cbab5fc47d
https://doi.org/10.1016/j.dmpk.2018.09.193
https://doi.org/10.1016/j.dmpk.2018.09.193