Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Sudarshan Anand"'
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-9 (2023)
Abstract Activation of nucleic acid sensors in endothelial cells (ECs) has been shown to drive inflammation across pathologies including cancer, atherosclerosis and obesity. We previously showed that enhancing cytosolic DNA sensing by inhibiting thre
Externí odkaz:
https://doaj.org/article/5a8e79b82ce24fb181293841cbe3b05d
Autor:
Katherine M. Watson, Kyla N. Siemens, Sudarshan Anand, Ivy H. Gardner, Thomas J. Sharpton, Elizabeth N. Dewey, Robert Martindale, Christopher A. Gaulke, Vassiliki Liana Tsikitis
Publikováno v:
Gut Pathogens, Vol 14, Iss 1, Pp 1-6 (2022)
Abstract Background Microbial dysbiosis has been closely linked with colorectal cancer development. However, data is limited regarding the relationship of the mucosal microbiome, adenomatous polyps and dietary habits. Understanding these associations
Externí odkaz:
https://doaj.org/article/8c145efae3a94e998eb3606d7cbb68fc
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Enhancing the immune microenvironment in cancer by targeting the nucleic acid sensors is becoming a potent therapeutic strategy. Among the nucleic acid sensors, activation of the RNA sensor Retinoic Acid-inducible Gene (RIG-I) using small hairpin RNA
Externí odkaz:
https://doaj.org/article/7dd86a384b15482e9ecafcb4c1fc1171
Autor:
Namita Chatterjee, Eugenia Fraile-Bethencourt, Adrian Baris, Cristina Espinosa-Diez, Sudarshan Anand
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Defects in stress responses are important contributors in many chronic conditions including cancer, cardiovascular disease, diabetes, and obesity-driven pathologies like non-alcoholic steatohepatitis (NASH). Specifically, endoplasmic reticulum (ER) s
Externí odkaz:
https://doaj.org/article/6160a66d8851434fa7e9206a22d6ebbb
Autor:
Michael C. Schmid, Samia Q. Khan, Megan M. Kaneda, Paulina Pathria, Ryan Shepard, Tiani L. Louis, Sudarshan Anand, Gyunghwi Woo, Chris Leem, M. Hafeez Faridi, Terese Geraghty, Anugraha Rajagopalan, Seema Gupta, Mansoor Ahmed, Roberto I. Vazquez-Padron, David A. Cheresh, Vineet Gupta, Judith A. Varner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimula
Externí odkaz:
https://doaj.org/article/fa609fba06764331883a98cafef892a0
Autor:
Rebecca Ruhl, Shushan Rana, Katherine Kelley, Cristina Espinosa-Diez, Clayton Hudson, Christian Lanciault, Charles R. Thomas, V. Liana Tsikitis, Sudarshan Anand
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Colorectal cancer (CRC) is a leading cause of cancer-related death. The biologic response of CRC to standard of care adjuvant therapies such as chemotherapy and radiation are poorly understood. MicroRNAs (miRs) have been shown to
Externí odkaz:
https://doaj.org/article/84e12b3700074dae815f54c861942d61
Autor:
Luai R. Zarour, Sudarshan Anand, Kevin G. Billingsley, William H. Bisson, Andrea Cercek, Michael F. Clarke, Lisa M. Coussens, Charles E. Gast, Cristina B. Geltzeiler, Lissi Hansen, Katherine A. Kelley, Charles D. Lopez, Shushan R. Rana, Rebecca Ruhl, V. Liana Tsikitis, Gina M. Vaccaro, Melissa H. Wong, Skye C. Mayo
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 163-173 (2017)
In patients with colorectal cancer (CRC) that metastasizes to the liver, there are several key goals for improving outcomes including early detection, effective prognostic indicators of treatment response, and accurate identification of patients at
Externí odkaz:
https://doaj.org/article/a2fb9ed7dbcc4a7e9cfe57e90dde9948
Autor:
RaeAnna Wilson, Cristina Espinosa-Diez, Nathan Kanner, Namita Chatterjee, Rebecca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Sushil Kumar, Lisa M. Coussens, Daniel G. Anderson, Clark C. Chen, David A. Cheresh, Sudarshan Anand
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflam
Externí odkaz:
https://doaj.org/article/a01c9f15bea14236bb83264f01ebc409
Autor:
Sudarshan Anand Shetty, Nachiket Prakash Marathe, Vikram Lanjekar, Dilip Ranade, Yogesh S Shouche
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79353 (2013)
With increasing number of novel bacteria being isolated from the human gut ecosystem, there is a greater need to study their role in the gut ecosystem and their effect on the host health. In the present study, we carried out in silico genome-wide ana
Externí odkaz:
https://doaj.org/article/6ba57a8c98fb418889a1629147778efa
Autor:
Steven K M Lau, David J Shields, Eric A Murphy, Jay S Desgrosellier, Sudarshan Anand, Miller Huang, Shumei Kato, Ssang-Taek Lim, Sara M Weis, Dwayne G Stupack, David D Schlaepfer, David A Cheresh
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36753 (2012)
Receptor tyrosine kinases and integrins play an essential role in tumor cell invasion and metastasis. We previously showed that EGF and other growth factors induce human carcinoma cell invasion and metastasis mediated by integrin αvβ5 that is preve
Externí odkaz:
https://doaj.org/article/15170b8377a74486a4a1f9c4d8ba950e