Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sudarkodi Alagarsamy"'
Autor:
Sudarkodi Alagarsamy, Claudio D. Schteingart, Mark Lu, Karthik Srinivasan, Violetta Dimitriadou, Halina Wiśniewska, Regent Laporte, Jennifer Hartwig, Pierre Riviere, Kazimierz Wiśniewski, Steve Qi, Alexander P. Posch, Glenn Croston, Javier Sueiras-Diaz, Diane M. Hargrove
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:193-203
Glucagon-like peptide-2 (GLP-2) agonists have therapeutic potential in clinical indications in which the integrity or absorptive function of the intestinal mucosa is compromised, such as in short bowel syndrome (SBS). Native hGLP-2, a 33-amino acid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::509ac6998d82eff3f2d26f82d067b498
https://doi.org/10.1124/jpet.119.262238
https://doi.org/10.1124/jpet.119.262238
Autor:
Pierre Riviere, John J. Dwyer, John Kraus, Claudio D. Schteingart, Guangcheng Jiang, Nicky Ferdyan, Jennifer Hartwig, Yung-Chih Wang, Kazimierz Wiśniewski, Karthik Srinivasan, Steve Qi, Mark Lu, Dorain Thompson, Sudarkodi Alagarsamy, Monica Mares, Regent Laporte, Halina Wiśniewska, Robert Galyean, Alexander P. Posch, Glenn Croston, Javier Sueiras-Diaz, Diane M. Hargrove
Publikováno v:
Journal of Medicinal Chemistry. 59:3129-3139
Glucagon-like peptide-2 receptor agonists have therapeutic potential for the treatment of intestinal diseases. The native hGLP-2, a 33 amino acid gastrointestinal peptide, is not a suitable clinical candidate, due to its very short half-life in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d0de85816c7c44911645bd01597a6a
https://doi.org/10.1021/acs.jmedchem.5b01909
https://doi.org/10.1021/acs.jmedchem.5b01909
Autor:
Dorain Thompson, Pierre Riviere, Hiroe Tariga, Claudio D. Schteingart, Regent Laporte, Steve Qi, Kazimierz Wiśniewski, Robert Galyean, Glenn Croston, Sudarkodi Alagarsamy, Brian Ly, Halina Wiśniewska
Publikováno v:
Journal of Medicinal Chemistry. 57:5306-5317
Mothers of preterm babies frequently have difficulty establishing or maintaining lactation, thought to be due to interference with the milk ejection reflex. Administration of exogenous oxytocin can produce alveolar contraction and adequate breast emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f454a109c566ca08a03cedf655d9fb
https://doi.org/10.1021/jm500365s
https://doi.org/10.1021/jm500365s
Autor:
Glenn Croston, Hiroe Tariga, Joshua Heitzmann, Halina Wisniewska, Claudio D. Schteingart, Robert Galyean, Kazimierz Wisniewski, Arash Kohan, Sudarkodi Alagarsamy, Pierre Riviere, Regent Laporte
Publikováno v:
Journal of Medicinal Chemistry. 54:4388-4398
[Arg(8)]vasopressin (AVP) produces vasoconstriction via V(1a) receptor (V(1a)R)-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension. However, AVP also induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1355cf98b6db5955d267e3565bcef495
https://doi.org/10.1021/jm200278m
https://doi.org/10.1021/jm200278m
Publikováno v:
Journal of Neurochemistry. 62:400-403
In this study we demonstrate that 50 mM K+ stimulates the conversion of L-[3H]arginine to L-[3H]citrulline and that this effect is blocked by 10 microM N omega-nitro-L-arginine, a nitric oxide synthase inhibitor, and Ca(2+)-free conditions. Amiloride
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d66c3f82f2e0ec15dcc7d859290c677
https://doi.org/10.1046/j.1471-4159.1994.62010400.x
https://doi.org/10.1046/j.1471-4159.1994.62010400.x
Publikováno v:
Current Opinion in Neurobiology. 11:357-362
Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271e895641224f6464f8b79add305bc0
https://doi.org/10.1016/s0959-4388(00)00219-1
https://doi.org/10.1016/s0959-4388(00)00219-1
Publikováno v:
Journal of Neurotrauma. 15:627-633
Experimental traumatic brain injury (TBI) damages cerebral vascular endothelium and reduces cerebral blood flow (CBF). The nitric oxide synthase (NOS) substrate, L-arginine, prevents CBF reductions after TBI, but the mechanism is not known. This stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cee258df36d5fb2fae09e395a76280
https://doi.org/10.1089/neu.1998.15.627
https://doi.org/10.1089/neu.1998.15.627
Publikováno v:
Drug and Alcohol Dependence. 48:105-111
Dopamine (DA), at concentrations greater than 100 microM, has previously been demonstrated to be toxic to mesencephalic, striatal and dorsal root ganglion cell cultures. Pharmacological experiments suggest that DA also may play a role in the cortical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfd92792a292b4d80a33e3393267fe6
https://doi.org/10.1016/s0376-8716(97)00118-x
https://doi.org/10.1016/s0376-8716(97)00118-x
Autor:
John Dykert, Halina Wisniewska, Pierre Riviere, Glenn Croston, Claudio D. Schteingart, Brian Ly, Joshua Heitzmann, Kazimierz Wisniewski, Sudarkodi Alagarsamy, Jeannine Toy, Arash Kohan, Steve Qi, Erin La, Hiroe Tariga, Regent Laporte, Robert Galyean
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 337(3)
FE 202158, ([Phe 2 ,Ile 3 ,Hgn 4 ,Orn(iPr) 8 ]vasopressin, where Hgn is homoglutamine and iPr is isopropyl), a peptidic analog of the vasoconstrictor hormone [Arg 8 ]vasopressin (AVP), was designed to be a potent, selective, and short-acting vasopres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832b97c4734b53d030c1aeb5b6149057
https://pubmed.ncbi.nlm.nih.gov/21411496
https://pubmed.ncbi.nlm.nih.gov/21411496
Publikováno v:
Journal of Neurochemistry. 60:1739-1745
L-glutamate (3-1,000 microM) and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD; 10-1,000 microM), a selective agonist for the metabotropic glutamate receptor, stimulated the formation of inositol 1,4,5-trisphosphate in a concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76b46fba4752e9e8c577879bae48be8
https://doi.org/10.1111/j.1471-4159.1993.tb13398.x
https://doi.org/10.1111/j.1471-4159.1993.tb13398.x