Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Sudagar S Gurcha"'
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (LM), which are trafficked from the bacterium to t
Externí odkaz:
https://doaj.org/article/6d93ff76e3f4412dafd8078e53d92041
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/788b328ee3d0461e94235c15cafbf14f
DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
Autor:
Katherine A. Abrahams, Sarah M. Batt, Sudagar S. Gurcha, Natacha Veerapen, Ghader Bashiri, Gurdyal S. Besra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Mycobacterium tuberculosis is one of the global leading causes of death due to a single infectious agent. Pretomanid and delamanid are new antitubercular agents that have progressed through the drug discovery pipeline. These compounds are bi
Externí odkaz:
https://doaj.org/article/40bdd0a34d744b8786bc6a3db7dc1740
Autor:
Lu Zhang, Yao Zhao, Ruogu Gao, Jun Li, Xiuna Yang, Yan Gao, Wei Zhao, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Kajelle Kaur Besra, Wenqing Xu, Lijun Bi, Xian’en Zhang, Luke W. Guddat, Haitao Yang, Quan Wang, Gurdyal S. Besra, Zihe Rao
Publikováno v:
Protein & Cell, Vol 11, Iss 7, Pp 505-517 (2020)
Abstract Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA)
Externí odkaz:
https://doaj.org/article/e87abd4dde1941e494b09a4999a769d0
Autor:
Monika Jankute, Luke J. Alderwick, Alice R. Moorey, Maju Joe, Sudagar S. Gurcha, Lothar Eggeling, Todd L. Lowary, Anne Dell, Poh-Choo Pang, Tiandi Yang, Stuart Haslam, Gurdyal S. Besra
Publikováno v:
The Cell Surface, Vol 2, Iss , Pp 38-53 (2018)
The arabinan-containing polysaccharides, arabinogalactan (AG) and lipoarabinomannan (LAM), are key cell wall components of the Corynebacterineae, which include Corynebacteria, Norcadia and Mycobacteria. Both AG and LAM contain elaborate arabinan doma
Externí odkaz:
https://doaj.org/article/878dde211947413aaeecc3de06b0131f
Autor:
Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inh
Externí odkaz:
https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e
Autor:
Ling Qin, Luke W. Guddat, Lijie Wu, Ruogu Gao, Haitao Yang, Jun Li, Natacha Veerapen, Sudagar S. Gurcha, Qi Zhang, Quan Wang, Lijun Bi, Wei Zhao, Lu Zhang, Xiuna Yang, Yao Zhao, Yan Gao, Fangyu Wu, Yinan Wang, Chengyao Wu, Yan Zhu, Sarah M. Batt, Xian’en Zhang, Gurdyal S. Besra, Manfu Wang, Bing Zhang, Zihe Rao, Wenqing Xu
Publikováno v:
Science. 368:1211-1219
Drug inhibition of glycosyltransferasesMycobacteria, including the species that causes tuberculosis (TB), synthesize a complex cell wall that helps to support and protect the bacterial cells. The major components of the cell wall include complex hete
Autor:
Yao Zhao, Zihe Rao, Sudagar S. Gurcha, Quan Wang, Kajelle Kaur Besra, Jun Li, Ruogu Gao, Luke W. Guddat, Natacha Veerapen, Xian’en Zhang, Yan Gao, Lijun Bi, Gurdyal S. Besra, Xiuna Yang, Wenqing Xu, Wei Zhao, Lu Zhang, Sarah M. Batt, Haitao Yang
Publikováno v:
Protein & Cell, Vol 11, Iss 7, Pp 505-517 (2020)
Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its ar
Autor:
Esther J. M. Stoop, Tim Schipper, Sietske K. Rosendahl Huber, Alexander E. Nezhinsky, Fons J. Verbeek, Sudagar S. Gurcha, Gurdyal S. Besra, Christina M. J. E. Vandenbroucke-Grauls, Wilbert Bitter, Astrid M. van der Sar
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 4, Pp 526-536 (2011)
SUMMARY The hallmark of tuberculosis (TB) is the formation of granulomas, which are clusters of infected macrophages surrounded by additional macrophages, neutrophils and lymphocytes. Although it has long been thought that granulomas are beneficial f
Externí odkaz:
https://doaj.org/article/41d51854f4b84a878b3f42292ea9414f
Autor:
Sudagar S Gurcha, Veeraraghavan Usha, Jonathan A G Cox, Klaus Fütterer, Katherine A Abrahams, Apoorva Bhatt, Luke J Alderwick, Robert C Reynolds, Nicholas J Loman, VijayaShankar Nataraj, Carlos Alemparte, David Barros, Adrian J Lloyd, Lluis Ballell, Judith V Hobrath, Gurdyal S Besra
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113568 (2014)
The human pathogen Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis (TB), a disease with high worldwide mortality rates. Current treatment programs are under significant threat from multi-drug and extensively-drug resistant
Externí odkaz:
https://doaj.org/article/d85fbdf303054892bbf5d1a8ee379a42