Výsledky vyhledávání - "Suckling, C. J."

Summary ES‐62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)‐induced airway hyper‐responsiveness in mice by virtue of covalently attached anti‐inflammatory phosphorylcholine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::590c47c9cdee841199aebdf6a7f315d7
http://europepmc.org/articles/PMC4913752

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Akademický článek

Chemical approaches to the discovery of new drugs

Autor: Suckling, C. J.

Publikováno v: Science Progress (1933- ), 1991 Jan 01. 753/4 (298), 323-359.

Externí odkaz: https://www.jstor.org/stable/43421277

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The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

Autor: Coltherd, J. C., Rodgers, D. T., Lawrie, R. E., Al-Riyami, L., Suckling, C. J., Harnett, W., Harnett, M. M.

Publikováno v: Scientific Reports

Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::759f4e2dd0a107208427f2c8d4476d33

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Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

Autor: Rodgers, D. T., Pineda, M. A., Suckling, C. J., Harnett, W., Harnett, M. M.

Publikováno v: Lupus

Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE). However, ES-62 is not suitab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f0d3cf9595a1766c82d7d96840ecb526
https://eprints.gla.ac.uk/106060/1/106060.pdf