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Akademický článek

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Protein Sequencing Research Group (PSRG): Results of the PSRG 2012 Study Year 1: Terminal Sequencing of Fusion Proteins

Autor: English, R.D., Jalili, P.R., Katta, V., Mawuenyega, K., Simpson, J., Suckau, D., Walters, J.J., Xiang, B., Remmer, Henriette

Establishing the N-terminal sequence of intact proteins plays a critical role in biochemistry and drug development. N-terminal sequence analysis is necessary for quality control of protein biologics, for determining sites of signal peptide cleavage e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_dedup___::00b59da30a75d87e4a797dba609f9b4d
https://europepmc.org/articles/PMC3630606/

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Characterization of Unexpected By-Products in a Recombinant TAU Protein by Capillary LC Coupled to MALDI-Top-Down-Sequencing (LCMALDI-TDS)

Autor: Kovacech, B., Kovac, A., Suckau, D., Asperger, A.

Compared to Edman sequencing, MALDI-TOFMS based top-down sequencing of proteins (MALDI-TDS) is much faster, cheaper, can deliver significantly longer sequence readout from both, protein Nand C-terminus, and has no limitations in case of terminally mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::3195da8da69bc270364324cfe06e493b
https://europepmc.org/articles/PMC3186551/

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Protein Sequencing Research Group(PSRG): Results of the PSRG 2011 Study: Sensitivity Assessment of Edman and Mass Spectrometric Terminal Sequencing of an Unknown Protein

Autor: Smith, J.S., Sandoval, W., Xiang, B., Mawuenyega, K., Suckau, D., Katta, V., Walters, J.J., Hunziker, P., Remmer, H.

Establishing the N-terminal sequence of intact proteins plays a critical role in biochemistry and potential drug development. N-terminal sequence analysis is necessary for quality control of protein biologics for determining sites of signal peptide c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::5bc418eb555f9f9a0778b4b10ec04c16
https://europepmc.org/articles/PMC3186630/

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N-Glycosylation of Antibodies Characterized by Mass Spectrometry: An Integrated Software Approach

Autor: Asperger, A., Resemann, A., Suckau, D., Schweiger-Hufnagel, U.

Antibodies represent one of the most important classes of glycoproteins playing a central role in the immune response of living organisms. Furthermore, there is a growing interest in recombinant antibodies as potential biotherapeutic agents. The anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::ab1767f8b07ec02972916981fce4f954
https://europepmc.org/articles/PMC3186588/

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PSRG 2011 Study Results: Sensitivity Assessment of Terminal Sequencing Techniques Using an Unknown Protein

Autor: Sandoval, W., Mawuenyega, K., Smith, J.S., Remmer, H., Xiang, B., Suckau, D., Katta, V., Hunziker, P., Walters, J.J.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::1c2df69ae74d08ff384a152ef90dbcea
https://europepmc.org/articles/PMC3186680/

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Fast QC of Intact Monoclonal Antibodies Using MALDI-Top-Down Sequencing

Autor: Paape, R., Vorwerg, L., Suckau, D., Resemann, A.

Antibodies are playing an important role in drug development in the last years. The function of therapeutic monoclonal antibodies (mAbs) is directly depending on their structure including terminal modifications like C-terminal lysine excision and N-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::4d7d9b336f9feabb6131dbdc2de90b05
https://europepmc.org/articles/PMC3186624/

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Spatial Proteomics: A New LCMS/MS Tissue Imaging Workflow Providing Protein Identities and Their Distribution in Tissue

Autor: Schurenberg, M., Becker, M., Paape, R., Suckau, D., Lübbert, C.

MALDI-Imaging of proteins in tissue sections has established itself as a powerful new approach to biomarker discovery and histopathological research in recent years. However, the lack of direct identification strategies continues to be an obstacle pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::2f8033f6a2c4227ca3f3f0010cdb556a
https://europepmc.org/articles/PMC3186671/

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Top-Down Mass Spectrometric Sequence Analysis of 116 kDa E. coli β-galactosidase

Autor: Paape, R., Vorwerg, L., Suckau, D., Resemann, A.

Most Top-Down mass spectrometric studies performed so far focused on proteins in the 20-50 kDa range, even monoclonal antibodies are comprised of protein chains smaller than 50 kDa. However, the interest in large protein top-down analysis increases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::dc5cec791ed6c67e7e3e0252710b97e4
https://europepmc.org/articles/PMC3186526/

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