Výsledky vyhledávání - "Suchreet Takhar"

Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim

Autor: Patricia V. Schoenlein, Muthusamy Thangaraju, April Eve Welborn, Adam D. Singer, Derek LeRoith, Mario B. Marrero, Suchreet Takhar, Michael R. Dohn, Sudharsan Periyasamy-Thandavan, William Hutch Jackson, Shuang Huang

Publikováno v: Breast Cancer Research : BCR

Introduction In this pre-clinical in vitro study conducted in estrogen receptor positive (ER+) breast cancer cells, we have characterized the effects of insulin-like growth factor I (IGF-1) on the cytostatic and cytotoxic action of antiestrogen treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65acc3b78e205a83bbe23e1a49768d0c
https://pubmed.ncbi.nlm.nih.gov/22429491

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Abstract 1005: Dual targeting of MEK/MAPK1/2 and pro-survival autophagy to optimize antiestrogen treatment toward the eradication of antiestrogen resistant breast cancer

Autor: Michael Cheng, Mathew Manning, Patricia V. Schoenlein, Darren D. Browning, Thomas Barrett, Sudharsan Periyasamy-Thandavan, Muthusamy Thangaraju, Suchreet Takhar, Meghan E. McGee-Lawrence, William D. Hill

Publikováno v: Cancer Research. 75:1005-1005

In past studies, we showed that pro-survival autophagy mediates resistance to antiestrogen-induced apoptosis and facilitates the emergence of antiestrogen resistant breast cancer cells (Sammadar et al., Molecular Cancer Ther. 9, 2008). We also identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b593d49e7275539e9bbde603d184815d
https://doi.org/10.1158/1538-7445.am2015-1005

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Abstract B50: MEK inhibitors mount a two-pronged attack to kill estrogen receptor positive (ER+) breast cancer cells undergoing hormonal therapy: Attenuated autophagy and induction of apoptosis

Autor: Sudharsan Periyasamy-Thandavan, Patricia V. Schoenlein, Muthusamy Thangaraju, R. Padi, William D. Hill, Erhard Bieberich, M. Dix, Alexander J. Eason, Vadivel Ganapathy, Darren D. Browning, Matthew Manning, Suchreet Takhar

Publikováno v: Molecular Cancer Research. 12:B50-B50

In a recent study, we identified the dephosphorylated form of BimEL as a key death effector of antiestrogen treatment of ER+ breast cancer cells and further showed that MEK1/MAPK1/2 blockade was required to produce high levels of dephosphorylated Bim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be6e1d37b99f24546326a3db776bb3e5
https://doi.org/10.1158/1557-3125.rasonc14-b50

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Abstract 1725: HDAC inhibition induces Bim expression and apoptosis in breast cancer cells undergoing paclitaxel or antiestrogen treatment

Autor: Aric Berning, Patricia V. Schoenlein, Nathan Gilley, Muthusamy Thangaraju, Sally Elshafey, Alexander J. Eason, Suchreet Takhar

Publikováno v: Cancer Research. 73:1725-1725

Paclitaxel functions by preventing microtubule degradation, leading to mitotic arrest and apoptotic death. Of particular interest, paclitaxel-induced death in breast cancer cells is dependent, in part, on the levels of BimEL, a pro-apoptotic member o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6566331481a86f22dfc9022a98d804da
https://doi.org/10.1158/1538-7445.am2013-1725

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Abstract 2: IGF-1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER + breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim

Autor: Patricia V. Schoenlein, Sudharsan Periyasamy-Thandavan, William Hutch Jackson, Suchreet Takhar, Shuang Huang

Publikováno v: Cancer Research. 71:2-2

In an effort to understand the underlying mechanisms of inherent antiestrogen resistance in estrogen receptor positive (ER+) breast cancer cells, we have been studying the pro-survival role of insulin-like growth factor 1 (IGF-1) in protecting breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb222bf7c936064ed8047390e401699c
https://doi.org/10.1158/1538-7445.am2011-2

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Abstract 3783: Molecular targeting of sphingosine kinase increases the efficacy of hormonal therapy for breast cancer by blocking the catabolic function of autophagy

Autor: Sudharsan Periyasamy-Thandavan, Patricia V. Schoenlein, Erhard Bieberich, John R. Barrett, Suchreet Takhar, Amanda Rowland

Publikováno v: Cancer Research. 71:3783-3783

In our past studies, we have implicated autophagy as a mechanism of cell survival that contributes to the development of antiestrogen resistance in breast cancer cells (Autophagy. 2009 Apr; 5(3): 400-3). The breast cancer model system used to establi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d68c9b73d8363b5bb089968ce8f60ba
https://doi.org/10.1158/1538-7445.am2011-3783

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Abstract 4845: TONDU, a transcription factor that regulates prosurvival autophagy and the development of antiestrogen resistance in breast cancer

Autor: William Hutch Jackson, Patricia V. Schoenlein, Darren D. Browning, Julia S. Samaddar, Sudharsan Periyasamy-Thandavan, Suchreet Takhar, Adam D. Singer

Publikováno v: Cancer Research. 70:4845-4845

In recent studies, we have demonstrated that autophagy is essential for the survival of estrogen receptor positive (ER+) breast cancer cells during anti-estrogen therapy and facilitates the development of antiestrogen resistance. For these studies, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a71eff39d2e640fb55d3d74c6675e98
https://doi.org/10.1158/1538-7445.am10-4845

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Abstract 4846: IGF1 attenuates autophagic catabolism and apoptotic cell death in hormonally treated breast cancer cells via a MEK1 pathway

Autor: Patricia V. Schoenlein, Adam D. Singer, Sudharsan Periyasamy-Thandavan, Suchreet Takhar, William D. Hill, Samuel Herberg, William Hutch Jackson, Shuang Huang

Publikováno v: Cancer Research. 70:4846-4846

In recent studies, we and others showed that autophagy is one of the prosurvival mechanisms during anti-estrogen therapy that plays a significant role in the development of resistance. In this study, we sought to determine if autophagy plays a role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0e93f51ee884f0f0cb5d71afe2baff
https://doi.org/10.1158/1538-7445.am10-4846

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