Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Suchithranga M. D. C. Perera"'
Autor:
Steven D. E. Fried, Kushani S. K. Hewage, Anna R. Eitel, Andrey V. Struts, Nipuna Weerasinghe, Suchithranga M. D. C. Perera, Michael F. Brown
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(21)
The Rhodopsin family of G-protein–coupled receptors (GPCRs) comprises the targets of nearly a third of all pharmaceuticals. Despite structural water present in GPCR X-ray structures, the physiological relevance of these solvent molecules to rhodops
Autor:
Blake Mertz, Steven D. E. Fried, Michael F. Brown, Michael C. Pitman, Udeep Chawla, Nipuna Weerasinghe, Andrey V. Struts, Suchithranga M. D. C. Perera, Anna R. Eitel
Publikováno v:
Angewandte Chemie International Edition. 60:2288-2295
Visual rhodopsin is an important archetype for G-protein-coupled receptors, which are membrane proteins implicated in cellular signal transduction. Herein, we show experimentally that approximately 80 water molecules flood rhodopsin upon light absorp
Autor:
Suchithranga M. D. C. Perera, Michael F. Brown, Andrey V. Struts, Steven D. E. Fried, Nipuna Weerasinghe
Publikováno v:
The FASEB Journal. 35
Autor:
Michael F. Brown, Suchithranga M. D. C. Perera, Nipuna Weerasinghe, Andrey V. Struts, Steven D. E. Fried
Publikováno v:
The FASEB Journal. 35
Autor:
James E. Keener, William C. Resager, James G. Rohrbough, Steven D. E. Fried, Suchithranga M. D. C. Perera, Nipuna Weerasinghe, Carolanne E. Norris, Michael F. Brown, Michael T. Marty
Publikováno v:
Int J Mass Spectrom
Rhodopsin, a prototypical G-protein-coupled receptor, is responsible for scoptic vision at low-light levels. Although rhodopsin's photoactivation cascade is well understood, it remains unclear how lipid and zinc binding to the receptor are coupled. U
Autor:
Suchithranga M. D. C. Perera, Benjamin H. C. Cabrera, Anna R. Eitel, Michael F. Brown, Andrey V. Struts, Nipuna Weerasinghe, Kushani S. K. Hewage, Steven D. E. Fried
Publikováno v:
Biophysical Journal. 120:130a-131a
Autor:
Michael F. Brown, Suchithranga M. D. C. Perera, Charitha Guruge, Xiaolin Xu, Andrey V. Struts, Trivikram R. Molugu, Carolina L. Nascimento, Mikhail N. Ryazantsev, Samira Faylough
Publikováno v:
Biophysical Journal. 118:362a-363a
Publikováno v:
The Journal of Physical Chemistry Letters. 7:4230-4235
Preparation and storage of functional membrane proteins such as G-protein-coupled receptors (GPCRs) are crucial to the processes of drug delivery and discovery. Here, we describe a method of preparing powdered GPCRs using rhodopsin as the prototype.
Autor:
Michael F. Brown, Suchithranga M. D. C. Perera, Eugene Mamontov, Xiang-Qiang Chu, Utsab R. Shrestha, Udeep Chawla, Debsindhu Bhowmik
Publikováno v:
The Journal of Physical Chemistry Letters. 7:4130-4136
Light activation of the visual G-protein-coupled receptor (GPCR) rhodopsin leads to significant structural fluctuations of the protein embedded within the membrane yielding the activation of cognate G-protein (transducin), which initiates biological
Autor:
Suchithranga M. D. C. Perera, Anna R. Eitel, Steven D. E. Fried, Nipuna Weerasinghe, Michael F. Brown, Margaret R. Vos, Gabrielle I. Fitzwater, Carolanne E. Norris, Johnathan D. Somers, Michael C. Pitman, Andrey V. Struts
Publikováno v:
The FASEB Journal. 33