Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid.

Autor: Samantha Yuille, Nicole Reichardt, Suchita Panda, Hayley Dunbar, Imke E Mulder

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201073 (2018)

Overexpression of histone deacetylase (HDAC) isoforms has been implicated in a variety of disease pathologies, from cancer and colitis to cardiovascular disease and neurodegeneration, thus HDAC inhibitors have a long history as therapeutic targets. T

Externí odkaz: https://doaj.org/article/d9aa54285a2341e8919a2951ebf499aa

Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers ColitisSummary

Autor: Monika Schaubeck, Chaysavanh Manichanh, Stephanie Heinzlmeir, Christina Ludwig, Bernhard Kuster, Dirk Haller, Hongsup Yoon, Hannes Hahne, Andreas Blesl, Suchita Panda, Thomas Clavel, Gabriele Hörmannsperger, Ilias Lagkouvardos, Patrizia Kump

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 370-388.e3 (2018)
Cellular and Molecular Gastroenterology and Hepatology 6(3), 370-388.e3 (2018). doi:10.1016/j.jcmgh.2018.05.008
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Antibiotic (ABx) therapy is associated with increased risk for Crohn’s disease but underlying mechanisms are unknown. We observed high fecal serine protease activity (PA) to be a frequent side effect of ABx therapy. The aim of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8ccb8d696933694ad56d897be100e3
http://www.sciencedirect.com/science/article/pii/S2352345X18300845

Microbiome Composition by Pyrosequencing in Mesenteric Lymph Nodes of Rats with CCl4-Induced Cirrhosis

Autor: Suchita Panda, Ismail El khader, Cándido Juárez, Chaysavanh Manichanh, Alba Santiago, Francesc J. Sancho, Elisabet Sánchez, Silvia Cuenca, Germán Soriano, Silvia Vidal, Juan C. Nieto, Carlos Guarner, Francisco Guarner

Publikováno v: Journal of Innate Immunity. 6:263-271

Background: The cross talk between the gut microbiota and the immune system, which is essential to maintain homeostasis, takes place at the intestinal lymphoid tissue such as the mesenteric lymph nodes (MLNs). Here, we investigated the presence of ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8b75673fada1c700cdf726e7674843b
https://doi.org/10.1159/000356454

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome

Autor: Chaysavanh Manichanh, Javier Santos, Anna Accarino, Francisco Guarner, Alba Santiago, Marta Pozuelo, Suchita Panda, Sara Mendez, Fernando Azpiroz

Publikováno v: Scientific Reports

The pathophysiology of irritable bowel syndrome (IBS) remains unclear. Here we investigated the microbiome of a large cohort of patients to identify specific signatures for IBS subtypes. We examined the microbiome of 113 patients with IBS and 66 heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eacc01797d54e5d5796a1f9806e81de
https://doi.org/10.1038/srep12693

Microbiome composition by pyrosequencing in mesenteric lymph nodes of rats with CCl4-induced cirrhosis

Autor: Silvia, Cuenca, Elisabet, Sanchez, Alba, Santiago, Ismail, El Khader, Suchita, Panda, Silvia, Vidal, Juan, Camilo Nieto, Cándido, Juárez, Francesc, Sancho, Francisco, Guarner, German, Soriano, Carlos, Guarner, Chaysavanh, Manichanh

Publikováno v: Journal of innate immunity. 6(3)

BACKGROUND: The cross talk between the gut microbiota and the immune system, which is essential to maintain homeostasis, takes place at the intestinal lymphoid tissue such as the mesenteric lymph nodes (MLNs). Here, we investigated the presence of ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::094f6e92067bedc1213eec1ccf5b3d6a
https://pubmed.ncbi.nlm.nih.gov/24296725