Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sucheol Gil"'
Autor:
Hongjie Wang, Aphrodite Georgakopoulou, Wenli Zhang, Jiho Kim, Sucheol Gil, Anja Ehrhardt, André Lieber
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 213-226 (2023)
In previous studies, we achieved safe and efficient in vivo hematopoietic stem cell (HSC) transduction in mobilized mice and macaques with intravenously injected helper-dependent adenovirus HDAd5/35++ vectors. These vectors are derivatives of serotyp
Externí odkaz:
https://doaj.org/article/a88308c12b0348839b57ede7b7c9e6d6
Autor:
Jiho Kim, Chang Li, Hongjie Wang, Swarnendu Kaviraj, Sanjay Singh, Laxman Savergave, Arjun Raghuwanshi, Sucheol Gil, Audrey Germond, Audrey Baldessari, Bingmae Chen, Steve Roffler, Pascal Fender, Charles Drescher, Darrick Carter, André Lieber
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Our goal is to overcome treatment resistance in ovarian cancer patients which occurs in most cases after an initial positive response to chemotherapy. A central resistance mechanism is the maintenance of desmoglein-2 (DSG2) positive tight ju
Externí odkaz:
https://doaj.org/article/f750a078157146a4b349ea4bf8b95d18
Autor:
Chang Li, Hongjie Wang, Sucheol Gil, Audrey Germond, Connie Fountain, Audrey Baldessari, Jiho Kim, Zhinan Liu, Aphrodite Georgakopoulou, Stefan Radtke, Tamás Raskó, Amit Pande, Christina Chiang, Eli Chin, Evangelia Yannaki, Zsuzsanna Izsvák, Thalia Papayannopoulou, Hans-Peter Kiem, André Lieber
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 127-141 (2022)
We tested a new in vivo hematopoietic stem cell (HSC) transduction/selection approach in rhesus macaques using HSC-tropic, integrating, helper-dependent adenovirus vectors (HDAd5/35++) designed for the expression of human γ-globin in red blood cells
Externí odkaz:
https://doaj.org/article/a2548131293548c5bd5f6c1dca0a370f
Autor:
Chang Li, Aphrodite Georgakopoulou, Gregory A. Newby, Kelcee A. Everette, Evangelos Nizamis, Kiriaki Paschoudi, Efthymia Vlachaki, Sucheol Gil, Anna K. Anderson, Theodore Koob, Lishan Huang, Hongjie Wang, Hans-Peter Kiem, David R. Liu, Evangelia Yannaki, André Lieber
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Individuals with β-thalassemia or sickle cell disease and hereditary persistence of fetal hemoglobin (HPFH) possessing 30% fetal hemoglobin (HbF) appear to be symptom free. Here, we used a nonintegrating HDAd5/35++ vector expressing a highly efficie
Externí odkaz:
https://doaj.org/article/ad903bbc1db4441484b871ef2cf704a3
Autor:
Hongjie Wang, Zhinan Liu, Chang Li, Sucheol Gil, Thalia Papayannopoulou, Christopher B. Doering, André Lieber
Publikováno v:
Blood Advances, Vol 3, Iss 19, Pp 2883-2894 (2019)
Abstract: We developed an in vivo hematopoietic stem cell (HSC) transduction approach that involves HSC mobilization from the bone marrow into the peripheral bloodstream and the IV injection of an integrating, helper-dependent adenovirus (HDAd5/35++)
Externí odkaz:
https://doaj.org/article/ca86c12adc4e42f4aadb9bf04b017b00
Autor:
Hongjie Wang, Aphrodite Georgakopoulou, Chang Li, Zhinan Liu, Sucheol Gil, Ashvin Bashyam, Evangelia Yannaki, Achilles Anagnostopoulos, Amit Pande, Zsuzsanna Izsvák, Thalia Papayannopoulou, André Lieber
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Recently, we demonstrated that hematopoietic stem/progenitor cell (HSPC) mobilization followed by intravenous injection of integrating, helper-dependent adenovirus HDAd5/35++ vectors resulted in efficient transduction of long-term repopulating cells
Externí odkaz:
https://doaj.org/article/b6464424f34f419e8252367facfc432c
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 390-401 (2018)
We generated helper-dependent HDAd5/35++ adenovirus vectors expressing CRISPR/Cas9 for potential hematopoietic stem cells (HSCs) gene therapy of β-thalassemia and sickle cell disease through re-activation of fetal γ-globin expression (HDAd-globin-C
Externí odkaz:
https://doaj.org/article/060083c186d3436a8d48232cac400c12
Publikováno v:
Blood Advances. 6:4360-4372
We developed a new in vivo hematopoietic stem cell (HSC) gene therapy approach that involves only IV injections and does not require myeloablation/conditioning and HSC transplantation. In this approach, HSCs are mobilized from the bone marrow into th
Autor:
Chang Li, Anna Kate Anderson, Hongjie Wang, Sucheol Gil, Jiho Kim, Lishan Huang, Audrey Germond, Audrey Baldessari, Veronica Nelson, Katharine J. Bar, Christopher W. Peterson, John Bui, Hans-Peter Kiem, André Lieber
Publikováno v:
Mol Ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b195973c68766c12857baeb2f3335a60
https://europepmc.org/articles/PMC10124067/
https://europepmc.org/articles/PMC10124067/
Autor:
Chang Li, Aphrodite Georgakopoulou, Gregory A Newby, Peter J Chen, Kelcee A Everette, Kiriaki Paschoudi, Efthimia Vlachaki, Sucheol Gil, Anna K Anderson, Theodore Koob, Lishan Huang, Hongjie Wang, Hans-Peter Kiem, David R Liu, Evangelia Yannaki, André Lieber
Publikováno v:
Blood.
Sickle Cell Disease (SCD) is a monogenic disease caused by a nucleotide mutation in the β-globin gene. Current gene therapy studies are mainly focused on lentivirus vector-mediated gene addition or CRISPR/Cas9-mediated fetal globin reactivation, lea