Development of an automated, interference-free, 2D-LC-MS/MS assay for quantification of a therapeutic mAb in human sera.

Autor: Sucharski FK; Pharmacokinetic Sciences, Novartis Institute for Biomedical Research, CH-4022 Basel, Switzerland., Meier S; Pharmacokinetic Sciences, Novartis Institute for Biomedical Research, CH-4022 Basel, Switzerland.; Amt für Lebensmittelsicherheit und Veterinärwesen, Ressort Chemie Gräubernstrasse 12, CH-4410 Liestal, Switzerland., Miess C; Pharmacokinetic Sciences, Novartis Institute for Biomedical Research, CH-4022 Basel, Switzerland., Razavi M; SISCAPA Assay Technologies, Inc., Washington, DC 20009-3309, USA., Pope M; SISCAPA Assay Technologies, Inc., Washington, DC 20009-3309, USA., Yip R; SISCAPA Assay Technologies, Inc., Washington, DC 20009-3309, USA., Anderson NL; SISCAPA Assay Technologies, Inc., Washington, DC 20009-3309, USA., Pearson TW; SISCAPA Assay Technologies, Inc., Washington, DC 20009-3309, USA., Warren AP; Pharmacokinetic Sciences, Novartis Institute for Biomedical Research, CH-4022 Basel, Switzerland.; Salt River Integrated Bioanalysis GmbH, Bernoullistrasse 20, CH-4056 Basel, Switzerland., Krantz C; Pharmacokinetic Sciences, Novartis Institute for Biomedical Research, CH-4022 Basel, Switzerland.

Publikováno v: Bioanalysis [Bioanalysis] 2018 Jul 01; Vol. 10 (13), pp. 1023-1037. Date of Electronic Publication: 2018 Jul 04.