Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sucharita Senbanerjee"'
Autor:
Chinweike Ukomadu, Shuang Wang, Chi Zhang, Emily Bernstein, Amaia Lujambio, Dan Hasson, Elena Magnani, Sucharita SenBanerjee, Anal Desai, Kirsten C. Sadler
Publikováno v:
Dev Cell
Summary Two major functions of the epigenome are to regulate gene expression and to suppress transposons. It is unclear how these functions are balanced during physiological challenges requiring tissue regeneration, where exquisite coordination of ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbed790257c450d99315f04d2a9caa4
https://pubmed.ncbi.nlm.nih.gov/31273301
https://pubmed.ncbi.nlm.nih.gov/31273301
Autor:
Anal Desai, Yelena Chernyavskaya, Xintong Chen, Anja Lachenmayer, Chinweike Ukomadu, Kensuke Kojima, Josep M. Llovet, Swan N. Thung, Roderick T. Bronson, Yujin Hoshida, Raksha Mudbhary, Clara Alsinet, Augusto Villanueva, Sucharita SenBanerjee, M. Isabel Fiel, Kirsten C. Sadler, Kate Revill, Ravi Sachidanandam, Vinitha Jacob
Publikováno v:
Cancer Cell. 25(2):196-209
SummaryUbiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of DNA methylation that is highly expressed in many cancers. Here, we use transgenic zebrafish, cultured cells, and human tumors to demonstrate that UHRF1 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e80d602002198f61695dfdc98d9412
Autor:
Kirsten C. Sadler, Chinweike Ukomadu, Raksha Mudbhary, Atul Kulkarni, Amy L. Tien, Bernadette Goudreau, Shridar Ganesan, Sucharita SenBanerjee
Publikováno v:
Biochemical Journal. 435:175-185
UHRF1 [ubiquitin-like protein, containing PHD (plant homeodomain) and RING finger domains 1] is required for cell cycle progression and epigenetic regulation. In the present study, we show that depleting cancer cells of UHRF1 causes activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6298f534284651f24f84521feded1f5a
https://doi.org/10.1042/bj20100840
https://doi.org/10.1042/bj20100840
Autor:
Mukesh K. Jain, Sucharita SenBanerjee, Hiranmoy Das, Pallab Banerjee, Lin Zhiyong, G. Brandon Atkins, Samy Mir, Anne Hamik, Ajay Kumar
Publikováno v:
Circulation. 112:720-726
Background— Although 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are known to modulate endothelial function, the transcriptional mechanisms underlying these effects are incompletely understood. We hypothesized that Lung-Kru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5c1ba6eb3ef01b720ed685ddc235a3
https://doi.org/10.1161/circulationaha.104.525774
https://doi.org/10.1161/circulationaha.104.525774
UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis
Autor:
Elizabeth A. Loughlin, Jaime Chu, Brandon Kent, Chinweike Ukomadu, Sucharita SenBanerjee, Naseem A. Gaur, Vinitha Jacob, Christopher Monson, Kirsten C. Sadler, Amanke Oranu, Yuanying Ding
Publikováno v:
Molecular Biology of the Cell
Although UHRF1 is essential for many epigenetic marks, the mechanism that regulates UHRF1 is not understood. This study shows that a key component of the cell cycle machinery—cyclin-dependent kinase 2/cyclin A2—phosphorylates UHRF1 and that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d39a8f9fa6726eea0bc98ccc1a81979
https://pubmed.ncbi.nlm.nih.gov/22072796
https://pubmed.ncbi.nlm.nih.gov/22072796
Autor:
Charles P. Lin, Ling Li, Shi Yin Foo, Ann M. Dvorak, Anthony Rosenzweig, Joel A. Spencer, Tracey E. Sciuto, Parisa Zamiri, Matthew Coggins, Sucharita SenBanerjee, Dongxiao Shen, Michael Karin, Noboru Ashida, Shohta Kodama, Robert E. Gerszten
Publikováno v:
Nature Communications
Vascular endothelium provides a selective barrier between the blood and tissues, participates in wound healing and angiogenesis, and regulates tissue recruitment of inflammatory cells. Nuclear factor (NF)-κB transcription factors are pivotal regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c60e53149789e1137920e50ec199d2
https://doi.org/10.1038/ncomms1317
https://doi.org/10.1038/ncomms1317
Autor:
Noboru Ashida, Sucharita SenBanerjee, Shohta Kodama, Joel A Spencer, Parisa Zamiri, Ling Li, Robert E Gerszten, Charles P Lin, Michael Karin, Anthony Rosenzweig
Publikováno v:
Circulation. 116
The serine-threonine kinase, IKK-β, is required for classical activation of the NF-κB family of transcription factors which are central regulators of inflammation and cell survival that are activated in a variety of vascular diseases. [Methods and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ec3a143ee91bddbeb2ee7e50f3c910a
https://doi.org/10.1161/circ.116.suppl_16.ii_36-c
https://doi.org/10.1161/circ.116.suppl_16.ii_36-c
Autor:
Sudeshna Fisch, Otmar Pfister, Baiqiu Wang, Ulrike Mende, Christine A. Petersen, Barbara A. Burleigh, Mukesh K. Jain, Sucharita SenBanerjee, Yan Zhu, Lei Cui, Stephane Heymans, Ajay Kumar, Yigal M. Pinto, Ronglih Liao, Susan H. Gray, Saptarsi M. Haldar, Hiranmoy Das, Zhiyong Lin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 104(17), 7074-7079. National Academy of Sciences
Cardiac hypertrophy is a common response to injury and hemodynamic stress and an important harbinger of heart failure and death. Herein, we identify the Kruppel-like factor 15 (KLF15) as an inhibitor of cardiac hypertrophy. Myocardial expression of K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efc3b0c61ffb1d7e3fce102dd040d8
https://pure.amc.nl/en/publications/kruppellike-factor-15-is-a-regulator-of-cardiomyocyte-hypertrophy(21c96e7b-ae98-46c0-bf34-b7b50968bc21).html
https://pure.amc.nl/en/publications/kruppellike-factor-15-is-a-regulator-of-cardiomyocyte-hypertrophy(21c96e7b-ae98-46c0-bf34-b7b50968bc21).html
Publikováno v:
Biochemistry. 44(45)
Vascular endothelial growth factor (VEGF) plays a central role in vascular homeostasis. VEGF receptors (VEGFRs) include several subtypes that may have a differential role in endothelial signal transduction, but interactions among these receptors are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2658626f3fe9986d5eff6e663b92a7c2
https://pubmed.ncbi.nlm.nih.gov/16274253
https://pubmed.ncbi.nlm.nih.gov/16274253
Autor:
Maria A. Lebedeva, Akm Khyrul Wara, Sucharita SenBanerjee, Mark W. Feinberg, Zhuoxiao Cao, Mukesh K. Jain
Publikováno v:
The Journal of biological chemistry. 280(46)
Activation of macrophages is important in chronic inflammatory disease states such as atherosclerosis. Proinflammatory cytokines such as interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), or tumor necrosis factor-alpha can promote macrophage act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b797bc0a1ae4b88a3ffbd62db5ed68
https://pubmed.ncbi.nlm.nih.gov/16169848
https://pubmed.ncbi.nlm.nih.gov/16169848