Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Subul A. Beg"'
Autor:
Jennifer A. White, Fengting Wu, Saif Yasin, Milica Moskovljevic, Joseph Varriale, Filippo Dragoni, Angelica Camilo-Contreras, Jiayi Duan, Mei Y. Zheng, Ndeh F. Tadzong, Heer B. Patel, Jeanelle Mae C. Quiambao, Kyle Rhodehouse, Hao Zhang, Jun Lai, Subul A. Beg, Michael Delannoy, Christin Kilcrease, Christopher J. Hoffmann, Sébastien Poulin, Frédéric Chano, Cécile Tremblay, Jerald Cherian, Patricia Barditch-Crovo, Natasha Chida, Richard D. Moore, Michael F. Summers, Robert F. Siliciano, Janet D. Siliciano, Francesco R. Simonetti
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV) originating from CD4+ T cell clones car
Externí odkaz:
https://doaj.org/article/ef49646c2a614ed590cf85b7b8881c2b
Autor:
Robert F. Siliciano, Dorry L. Segev, Gregory M. Laird, Alexandra M. Bender, Sander Florman, Kyungyoon J. Kwon, Craig Martens, Alyssa R. Martin, Briana A. Lynch, Thomas C. Quinn, Aaron A.R. Tobian, Christine M. Durand, Jada Hackman, Daniel Bruno, Janet D. Siliciano, Niraj M. Desai, Subul A. Beg, Andrew D. Redd
Publikováno v:
J Infect Dis
Background The human immunodeficiency virus (HIV)-1 latent reservoir (LR) in resting CD4+ T cells is a barrier to cure. LR measurements are commonly performed on blood samples and therefore may miss latently infected cells residing in tissues, includ
Autor:
Jennifer A. White, Kenneth Lynn, Sarah E. Sweet, Robert F. Siliciano, Janet D. Siliciano, Luis J. Montaner, Jacqueline K Brockhurst, Lynn N. Bertagnolli, Subul A. Beg, Karam Mounzer, Ian Frank, Pablo Tebas, Katharine J. Bar, Francesco R. Simonetti, Joseph Varriale
Publikováno v:
Proc Natl Acad Sci U S A
In untreated HIV-1 infection, rapid viral evolution allows escape from immune responses. Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent reservoir in resting CD4(+) T cells, and rebound viremia occurs f
Autor:
Robert F. Siliciano, Cynthia K Bullen, Peggy Kim, Janet D. Siliciano, Subul A. Beg, Jun Lai, Emily J. Fray, Carrie Hetzel, Andrew E. Timmons, Chao Yang, Weiwei Dai, Steven A. Yukl, Fengting Wu, Joel L. Pomerantz, Mithra Kumar
Publikováno v:
Proceedings of the National Academy of Sciences. 117:15763-15771
HIV-1 latency is a major barrier to cure. Identification of small molecules that destabilize latency and allow immune clearance of infected cells could lead to treatment-free remission. In vitro models of HIV-1 latency involving cell lines or primary
Autor:
Peter Bacchetti, Carol Lackman-Smith, Mars Stone, Sheila M. Keating, Xutao Deng, Douglas D. Richman, Nicolas Chomont, Michael P. Busch, Amélie Pagliuzza, Roger G. Ptak, Subul A. Beg, Daniel I. S. Rosenbloom, Sonia Bakkour, Melanie Dimapasoc, John W. Mellors, Steven G. Deeks, Janet D. Siliciano, Jun Lai
Publikováno v:
The Journal of Infectious Diseases
Background Evaluations of human immunodeficiency virus (HIV) curative interventions require reliable and efficient quantification of replication-competent latent reservoirs. The “classic” quantitative viral outgrowth assay (QVOA) has been regarde
Autor:
Alexandra M. Bender, Janet D. Siliciano, Kyungyoon J. Kwon, Katherine M. Bruner, Hao Zhang, Christopher L. Nobles, Joshua T. Kufera, Gregory M. Laird, Steven G. Deeks, Ya Chi Ho, Annukka A.R. Antar, Lynn N. Bertagnolli, Frederic D. Bushman, Nikolas Wada, John R. Gregg, Srona Sengupta, Joseph B. Margolick, Subul A. Beg, Andrew E. Timmons, Adam A. Capoferri, Emily J. Fray, Katharine M. Jenike, Zheng Wang, Francesco R. Simonetti, Joel N. Blankson, Robert F. Siliciano
Publikováno v:
Nature
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays. The reservoir was defined with quant
Autor:
Christopher L. Nobles, Jennifer A. White, Kevin McCormick, Alison L. Hill, Frederic D. Bushman, Steven G. Deeks, Robert F. Siliciano, Janet D. Siliciano, Hayley Raymond, Subul A. Beg, John K. Everett, Joseph B. Margolick, Kyungyoon J. Kwon, Jun Lai, Jiayi Duan, Garshasb P. Soroosh, Kyle Rhodehouse, Hao Zhang, Francesco R. Simonetti, Rebecca Hoh
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 131, iss 3
The Journal of clinical investigation, vol 131, iss 3
Clonal expansion of infected CD4(+) T cells is a major mechanism of HIV-1 persistence and a barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 integration, and interaction with antigens. Here, we show that i
Autor:
Yang Hui Jimmy Yeh, Jianfei Hu, Rebecca Hoh, Sameet Mehta, Christine M. Durand, Jack A. Collora, Kristen Albrecht, Mihaela Pertea, Serena Spudich, Hao Zhang, Steven G. Deeks, Frederic D. Bushman, Ross A. Pollack, Jennifer Chiarella, Haiping Hao, Richard F. Ambinder, Rachela M. Calvi, Subul A. Beg, Ales Varabyou, C. Conover Talbot, Daniel C. Douek, Scott Sherrill-Mix, Ya Chi Ho, Runxia Liu
Publikováno v:
Sci Transl Med
Science translational medicine, vol 12, iss 543
Science translational medicine, vol 12, iss 543
Understanding HIV-1–host interactions can identify the cellular environment supporting HIV-1 reactivation and mechanisms of clonal expansion. We developed HIV-1 SortSeq to isolate rare HIV-1–infected cells from virally suppressed, HIV-1–infecte
Autor:
Jun Lai, Michael J. Peluso, Janet D. Siliciano, Jeffrey N. Martin, Subul A. Beg, Gregory M. Laird, Steven G. Deeks, Peter W. Hunt, Robert F. Siliciano, Peter Bacchetti, Timothy J. Henrich, Kristen D. Ritter
Publikováno v:
JCI insight, vol 5, iss 4
BACKGROUND: The relative stabilities of the intact and defective HIV genomes over time during effective antiretroviral therapy (ART) have not been fully characterized. METHODS: We used the intact proviral DNA assay (IPDA) to estimate the rate of chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5f9593675b65d2ba945d5ffba011bb
https://escholarship.org/uc/item/1tw656tz
https://escholarship.org/uc/item/1tw656tz
Autor:
Pablo Tebas, Robert F. Siliciano, Mohamed Abdel-Mohsen, Jun Lai, E. Turner Overton, Kevin McCormick, James A. Hoxie, Randall Tressler, Scott Sherrill-Mix, Janet M. Siliciano, Jonathan Z. Li, D. Brenda Salantes, Richard A. Koup, Tuhina Srivastava, Yu Zheng, Felicity Mampe, Gerald H. Learn, Frederic D. Bushman, Subul A. Beg, Katharine J. Bar
Publikováno v:
Journal of Clinical Investigation. 128:3102-3115
BACKGROUND. The effect of a brief analytical treatment interruption (ATI) on the HIV-1 latent reservoir of individuals who initiate antiretroviral therapy (ART) during chronic infection is unknown. METHODS. We evaluated the impact of transient viremi