The intrinsic substrate specificity of the human tyrosine kinome.

Autor: Yaron-Barir TM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Joughin BA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Huntsman EM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Kerelsky A; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Cizin DM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Cohen BM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Regev A; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Song J; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Vasan N; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA., Lin TY; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Discovery Technologies, Calico Life Sciences, South San Francisco, CA, USA., Orozco JM; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Schoenherr C; Cancer Research United Kingdom Scotland Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Sagum C; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bedford MT; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wynn RM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Tso SC; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chuang DT; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li L; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China., Li SS; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Canada., Creixell P; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Cancer Research UK Cambridge Institute, University of Cambridge Li Ka Shing Centre, Cambridge, UK., Krismer K; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Takegami M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Lee H; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Zhang B; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Lu J; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Cossentino I; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Landry SD; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Uduman M; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Blenis J; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA., Elemento O; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Frame MC; Cancer Research United Kingdom Scotland Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Hornbeck PV; Department Of Bioinformatics, Cell Signaling Technology, Danvers, MA, USA., Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Lewis_Cantley@dfci.harvard.edu.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Lewis_Cantley@dfci.harvard.edu.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Lewis_Cantley@dfci.harvard.edu., Turk BE; Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA. ben.turk@yale.edu., Yaffe MB; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. myaffe@mit.edu.; Division of Acute Care Surgery, Trauma, and Surgical Critical Care, and Division of Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. myaffe@mit.edu., Johnson JL; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. jaredl_johnson@dfci.harvard.edu.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. jaredl_johnson@dfci.harvard.edu.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. jaredl_johnson@dfci.harvard.edu.

Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8014), pp. 1174-1181. Date of Electronic Publication: 2024 May 08.

Improvement of substrate specificity of the direct electron transfer type FAD-dependent glucose dehydrogenase catalytic subunit.

Autor: Kerrigan JA Jr; Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA., Yoshida H; Department of Basic Life Science, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan., Okuda-Shimazaki J; Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA., Temple B; Department of Bioinformatics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Kojima K; Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan., Sode K; Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA. Electronic address: ksode@email.unc.edu.

Publikováno v: Journal of biotechnology [J Biotechnol] 2024 Nov 20; Vol. 395, pp. 170-179. Date of Electronic Publication: 2024 Sep 25.

Docking interactions determine substrate specificity of members of a widespread family of protein phosphatases.

Autor: Caban-Penix S; Molecular and Cell Biology Program, Brandeis University, Waltham, Massachusetts, USA; Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA., Ho K; Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA., Yang Z; Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA., Baral R; Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA; Biochemistry and Biophysics Program, Brandeis University, Waltham, Massachusetts, USA., Bradshaw N; Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA. Electronic address: niels@brandeis.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Sep; Vol. 300 (9), pp. 107700. Date of Electronic Publication: 2024 Aug 22.

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