Zobrazeno 1 - 10
of 1 314
pro vyhledávání: '"Substrate analog"'
Akademický článek
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Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Organic-rich, hydrothermal sediments of the Guaymas Basin are inhabited by diverse microbial communities including many uncultured lineages with unknown metabolic potential. Here we investigated the short-term effect of polysaccharide amendment on a
Externí odkaz:
https://doaj.org/article/5cd9356f039a4b60a267065f37d05c81
Akademický článek
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Publikováno v:
The FEBS Journal. 288:6019-6034
Staphylococcus aureus is a well-known clinical pathogenic bacterium. In recent years, due to the emergence of multiple drug-resistant strains of S. aureus in clinical practice, S. aureus infections have become an increasingly severe clinical problem.
Publikováno v:
Biophys J
MdfA from Escherichia coli is a prototypical secondary multi-drug (Mdr) transporter that exchanges drugs for protons. MdfA-mediated drug efflux is driven by the proton gradient and enabled by conformational changes that accompany the recruitment of d
Autor:
Andrew L. Lee, Jeffrey P. Bonin
Publikováno v:
Biomol NMR Assign
Human thymidylate synthase (hTS) is a 72 kDa homodimeric enzyme responsible for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), making it the sole source of de novo dTMP in human cells. As a result, hTS is
Publikováno v:
Reaction Chemistry & Engineering. 6:1940-1949
A non-covalent supramolecular enzyme system, which is formed by non-covalent interactions of an enzyme with substrate analogs, shows better enzyme catalytic activity than the enzyme itself. A non-covalent supramolecular laccase-dye substrate analog s
Autor:
Michael C. Newton-Vesty, Renwick C. J. Dobson, Santosh Panjikar, Christopher R Horne, James W. B. Moir, Rachel A. North, Rosmarie Friemann, Michael D. W. Griffin, James S Davies, Ramaswamy Subramanian, David Coombes, Thanuja Gangi Setty
Publikováno v:
J Biol Chem
In environments where glucose is limited, some pathogenic bacteria metabolize host-derived sialic acid as a nutrient source. N-Acetylmannosamine kinase (NanK) is the second enzyme of the bacterial sialic acid import and degradation pathway and adds p
Autor:
Jeerus Sucharitakul, Pimchai Chaiyen, Warintra Pitsawong, Anne-Frances Miller, Pirom Chenprakhon, Willem J. H. van Berkel, Dheeradhach Medhanavyn, Taweesak Dhammaraj, Chanakan Tongsook
Publikováno v:
Journal of Biological Chemistry, 295(12), 3965-3981
Journal of Biological Chemistry 295 (2020) 12
Journal of Biological Chemistry 295 (2020) 12
Hydroxylation of substituted phenols by flavin-dependent monooxygenases is the first step of their biotransformation in various microorganisms. The reaction is thought to proceed via electrophilic aromatic substitution, catalyzed by enzymatic deproto
Autor:
Xuefeng Lu, Yajing Liang
Publikováno v:
J Biol Chem
The lovastatin hydrolase PcEST from the fungus Penicillium chrysogenum exhibits enormous potential for industrial-scale applications in single-step production of monacolin J, the key precursor for synthesis of the cholesterol-lowering drug simvastati