Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Substantia Nigra/*metabolism"'
Autor:
Fiondella, Luigi, Gami-Patel, Priya, Blok, Christian A, Rozemuller, Annemieke J M, Hoozemans, Jeroen J M, Pijnenburg, Yolande A L, Scarioni, Marta, Dijkstra, Anke A
Publikováno v:
Acta neuropathologica communications, 11(1). BioMed Central
Movement disorders (MD) have been linked to degeneration of the substantia nigra (SN) in Parkinson's disease and include bradykinesia, rigidity, and tremor. They are also present in frontotemporal dementia (FTD), where MD have been linked to frontote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=narcis______::7d0720449c4d6ff2f9325340b49063f1
https://pure.knaw.nl/portal/en/publications/cc8e1c77-d7b7-40fc-92b5-a1137ce32075
https://pure.knaw.nl/portal/en/publications/cc8e1c77-d7b7-40fc-92b5-a1137ce32075
Publikováno v:
Acta neuropathologica communications. 11(1)
Movement disorders (MD) have been linked to degeneration of the substantia nigra (SN) in Parkinson's disease and include bradykinesia, rigidity, and tremor. They are also present in frontotemporal dementia (FTD), where MD have been linked to frontote
Autor:
Stefanie Seiler, Lukas Andereggen, Hans Rudolf Widmer, Ekkehard Hewer, Gian-Carlo Eyer, Stefano Di Santo
Publikováno v:
Eyer, Gian-Carlo; Di Santo, Stefano; Hewer, Ekkehard; Andereggen, Lukas; Seiler, Stefanie; Widmer, Hans Rudolf (2021). Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease. Cells, 10(12) MDPI 10.3390/cells10123368
Cells, Vol 10, Iss 3368, p 3368 (2021)
Cells
Cells; Volume 10; Issue 12; Pages: 3368
Cells, vol. 10, no. 12, pp. 3368
Cells, Vol 10, Iss 3368, p 3368 (2021)
Cells
Cells; Volume 10; Issue 12; Pages: 3368
Cells, vol. 10, no. 12, pp. 3368
Parkinson’s disease is mainly characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Together with the small number, the high vulnerability of the dopaminergic neurons is a major pathogenic culprit of Par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1658244281552db14bd32eb1a1c5138
Autor:
Liliane Tenenbaum, Abdelwahed Chtarto, Janica Wakkinen, Xin Yang, Olivier Bockstael, Catherine Melas, Jacques Brotchi, Marc Levivier
Publikováno v:
Human Gene Therapy, vol. 19, no. 11, pp. 1293-1305
The biodistribution of transgene expression in the CNS after localized stereotaxic vector delivery is an important issue for the safety of gene therapy for neurological diseases. The cellular specificity of transgene expression from rAAV2/1 vectors (
Publikováno v:
Journal of Neuroscience, vol. 17, no. 1, pp. 325-33
Parkinson’s disease (PD) is characterized by the progressive loss of the substantia nigra (SN) dopaminergic neurons projecting to the striatum. Neurotrophic factors may have the potential to prevent or slow down the degenerative process occurring i
Publikováno v:
The Journal of neuroscience, 21 (5
Scopus-Elsevier
Scopus-Elsevier
Nicotinic acetylcholine receptors (nAChRs) on dopaminergic (DA) and GABAergic (Gaba) projection neurons of the substantia nigra (SN) and ventral tegmental area (VTA) are characterized by single-cell RT-PCR and patch-clamp recordings in slices of rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86dedc8892e1d87c3d7a2f1e33b77091
https://hdl.handle.net/11380/304169
https://hdl.handle.net/11380/304169
Axonal transport of the vesicular monoamine transporter was assayed in the rat brain by in vivo binding of the specific ligand [3H]reserpine. Because of the marked localization of reserpine binding sites in dopaminergic cell bodies and nerve terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::74f3157c2373c60778e3bc5c229229bd
https://hal.science/hal-01602301
https://hal.science/hal-01602301
Recent findings of impaired mitochondrial function, altered iron metabolism and increased lipid peroxidation in the substantia nigra in Parkinson's disease emphasize the significance of oxidative stress and free radical formation in the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ee464ad67403000c9b7047fbeefed6
https://epub.uni-regensburg.de/25435/
https://epub.uni-regensburg.de/25435/
Reduced and oxidized glutathione concentrations in post-mortem brain tissue from the substantia nigra of control subjects and patients with neuropathologically confirmed Parkinson's disease were measured by a coulometric method using high-pressure li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45ca99355ff9ff01937d9d090197ba9
https://epub.uni-regensburg.de/25427/
https://epub.uni-regensburg.de/25427/
D1 and D2 receptor densities in human substantia nigra were examined by use of the specific binding of, respectively, [3H]SCH 23390 [R(+)-7-chloro-8-hydroxy-3-[3H]methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepine] and [3H]spiperone. A unilateral l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3848::ba6ab39824baaa183d4da66b2b6b3301
https://biblio.vub.ac.be/vubir/d1-and-d2-dopamine-receptors-in-human-substantia-nigra-localization-and-the-effect-of-aging(a147b901-0506-40cd-9eb3-c543d09e2915).html
https://biblio.vub.ac.be/vubir/d1-and-d2-dopamine-receptors-in-human-substantia-nigra-localization-and-the-effect-of-aging(a147b901-0506-40cd-9eb3-c543d09e2915).html