Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Subrata Shaw"'
Autor:
Peter G. Miller, Murugappan Sathappa, Jamie A. Moroco, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O. Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S. Sperling, Christopher J. Gibson, Josephine Kahn, Cyrus Jin, Matthew Ranaghan, Alisha Caliman, Merissa Brousseau, Eric S. Fischer, Robert Lintner, Federica Piccioni, Arthur J. Campbell, David E. Root, Colin W. Garvie, Benjamin L. Ebert
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this work, the authors report a sophisticated combination of genetic, biophysical, and biochemical analyses to identifies the cycling conformational states of PPM1D. The findings reveal how an allosteric inhibitor locks the protein into a conforma
Externí odkaz:
https://doaj.org/article/a652e8c526fe4774ba3ec46bd6f06545
Autor:
Logesh Rajan, Niranjan Das, Vijina Chakkyarath, Jeyakumar Natarajan, Dhanabal Palaniswamy, Subrata Shaw, Siddhartha Kumar Mishra
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100960- (2023)
Targeting obesity by altering the absorption of dietary triglycerides by inhibiting the pancreatic lipase is an interesting exploration. We aimed to understand the role of pancreatic lipase related protein 1 (PLRP1) and to explore whether flavonoids
Externí odkaz:
https://doaj.org/article/8e1ea54c41574b34a18fc193934473a1
Autor:
Dongdong Wang, Alexandru Sabin Bădărau, Mallappa Kumara Swamy, Subrata Shaw, Filippo Maggi, Luiz Everson da Silva, Víctor López, Andy Wai Kan Yeung, Andrei Mocan, Atanas G. Atanasov
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
Arctium species are known for a variety of pharmacological effects due to their diverse volatile and non-volatile secondary metabolites. Representatives of Arctium species contain non-volatile compounds including lignans, fatty acids, acetylenic comp
Externí odkaz:
https://doaj.org/article/732582325066421c97b80760897d7f19
Autor:
Peter G. Miller, Murugappan Sathappa, Jamie A. Moroco, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O. Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S. Sperling, Christopher J. Gibson, Josephine Kahn, Cyrus Jin, Matthew Ranaghan, Alisha Caliman, Merissa Brousseau, Eric S. Fischer, Robert Lintner, Federica Piccioni, Arthur J. Campbell, David E. Root, Colin W. Garvie, Benjamin L. Ebert
Publikováno v:
Nature communications. 13(1)
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK2830371 is a potent and selective allo
Autor:
Morsaline Billah, Ishaq N. Khan, Jamil A. Shilpi, Muhammad Torequl Islam, Nina Strzałkowska, Ferdinando Nicoletti, SU Yele, Gokhan Zengin, Kannan R.R. Rengasamy, Ioana Berindan-Neagoe, Andy Wai Kan Yeung, Subrata Shaw, Amirul Islam, Apostol Apostolov, Joanna Marchewka, Iqbal Ahmed, Amr El-Demerdash, Jarosław O. Horbańczuk, Diana Gulei, Siddhartha Kumar Mishra, Prasanta Kumar Dey, Mohammad Amjad Kamal, Manik Chandra Shill, Magdalena D. Pieczynska, Shaikh Jamal Uddin, Nagendra Sastry Yarla, Utpal Kumar Karmakar, Mohammad S. Mubarak, Maciej Banach, Atanas G. Atanasov, Jianbo Xiao, Eunus S. Ali, Artur Jóźwik, Clemens Malainer
Publikováno v:
Food and Chemical Toxicology. 121:82-94
Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a
Autor:
Muhammad Torequl Islam, Hasan Mahmud Reza, Razina Rouf, Shrabanti Dev, Asish Kumar Das, Manik Chandra Shill, Siddhartha Kumar Mishra, Shaikh Jamal Uddin, Mohammad S. Mubarak, Eunus S. Ali, Subrata Shaw, Jamil A. Shilpi, Ana Amélia de Carvalho Melo-Cavalcante, Keylla da Conceição Machado
Publikováno v:
Phytotherapy Research. 32:2376-2388
Beta (β)-caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotect
Autor:
Eamon Comer, Joshua B. Radke, Herbert W. Virgin, L. David Sibley, Kimberly L. Carey, Stuart L. Schreiber, Jose Perez, Carol Mulrooney, Shailesh Metkar, Robert Hilgraf, Subrata Shaw, Jennifer P. Gale, Joshua A. Bittker
Publikováno v:
ACS Infectious Diseases. 4:1499-1507
Toxoplasma gondii is an obligate intracellular parasite capable of causing severe disease due to congenital infection and in patients with compromised immune systems. Control of infection is dependent on a robust Th1 type immune response including pr
Autor:
Maria dos Remédios Mendes de Brito, Magdalena D. Pieczynska, Mohammad Amjad Kamal, Paulo Michel Pinheiro Ferreira, Shaikh Jamal Uddin, Vijai Kumar Gupta, Atanas G. Atanasov, Muhammad Torequl Islam, João Marcelo de Castro e Sousa, Hercília Maria Lins Rolim, Brahma N. Singh, José Williams Gomes de Oliveira Filho, Marcus Vinícius Oliveira Barros de Alencar, Niranjan Das, Eunus S. Ali, Andrei Mocan, Subrata Shaw, Antonio Luiz Gomes Júnior, Teresinha de Jesus Aguiar dos Santos Andrade, Sandra Maria Mendes de Moura Dantas, Maria das Graças Freire de Medeiros, Ana Amélia de Carvalho Melo-Cavalcante, Siddhartha Kumar Mishra, Márcia Fernanda Correia Jardim Paz, José Victor de Oliveira Santos
Publikováno v:
Food and Chemical Toxicology. 110:130-141
Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by severa
Autor:
Edward T. Olejniczak, Melissa A. Fischer, DeMarco V. Camper, Taekyu Lee, Lawrence H. Boise, Michael R. Savona, Leah Hogdal, Carrie F. Browning, Brian Koss, Bin Zhao, Anthony Letai, Johannes Belmar, James C. Tarr, Olivia W. Rossanese, Nagarathanam Veerasamy, Zhiguo Bian, Amit Budhraja, Shannon M. Matulis, Stephen W. Fesik, Subrata Shaw, John Sensintaffar, Joseph T. Opferman, Craig M. Goodwin, Allison L. Arnold
Publikováno v:
FEBS Letters. 591:240-251
Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins that when overexpressed is associated with high tumor grade, poor survival, and resistance to chemotherapy. Mcl-1 is amplified in many human cancers, and knockdown of Mcl-1 using RNAi
Autor:
Asish Kumar Das, Muhammad Torequl Islam, Seyed Soheil Saeedi Saravi, Razina Rouf, Shaikh Jamal Uddin, Swati Tripathi, Subrata Shaw, Eunus S. Ali, Shrabanti Dev, Ishaq N. Khan, Jamil A. Shilpi, SU Yele, Siddhartha Kumar Mishra, Mohammad S. Mubarak, Niranjan Das
Publikováno v:
Anti-cancer agents in medicinal chemistry. 20(14)
Background: Cancer is a dreadful disease causing thousands of deaths per year worldwide, which requires precision diagnostics and therapy. Although the selection of therapeutic regimens depends on the cancer type, chemotherapy remains a sustainable t