Executive Functions and Pre-Frontal Cortex: A Matter of Persistence?

Autor: Gareth eBall, Paul R Stokes, Rebecca A Rhodes, Subrata K Bose, Iead eRezek, Alle-Meije eWink, Louis-David eLord, Mitul A Mehta, Paul M Grasby, Federico E Turkheimer

Publikováno v: Frontiers in Systems Neuroscience, Vol 5 (2011)

Executive function is thought to originate in the dynamics of frontal cortical networks. We examined the dynamic properties of the blood oxygen level-dependent (BOLD) time-series measured with fMRI within the prefrontal cortex (PFC) to test the hypot

Externí odkaz: https://doaj.org/article/ce68e735e9da4da8b6e3c53a0e18193a

Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB

Autor: Naga Venkatesha Murthy, Rainer Hinz, Sudhakar Selvaraj, Zubin Bhagwagar, Subrata K. Bose, Paul M. Grasby, Philip J. Cowen

BACKGROUND: The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission and has been implicated in the pathophysiology of major depression. In a previous positron emission tomography study, we found no dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90c236015cd7a27cac9cc333afee5a8
https://doi.org/10.1007/s00213-009-1660-y

Dopamine Synthesis Capacity Before Onset of Psychosis: A Prospective [(18)F]-DOPA PET Imaging Study

Autor: Federico Turkheimer, Lucia Valmaggia, Robin M. Murray, Oliver D. Howes, Alice Egerton, Subrata K. Bose, Philip McGuire, Isabel Valli

Publikováno v: American Journal of Psychiatry, 168(12), 1311-1317. American Psychiatric Publishing, Inc.

While there is robust evidence of elevated dopamine synthesis capacity once a psychotic disorder has developed, little is known about whether it is altered prior to the first episode of frank illness. The authors addressed this issue by measuring dop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2983e5f91b43f84d39f276994b4b5cb2
https://doi.org/10.1176/appi.ajp.2011.11010160

Characterization of the anterior cingulate's role in the at-risk mental state using graph theory

Autor: Subrata K. Bose, Philip McGuire, Paul Allen, Samuel Hyde, Louis-David Lord, Renaud Lambiotte, Federico Turkheimer, Paul Expert, Oliver D. Howes

Publikováno v: Lord, L-D, Expert, P, Turkheimer, F E, Howes, O, McGuire, P, Lambiotte, R, Bose, S K, Hyde, S & Allen, P 2011, ' Characterization of the anterior cingulate's role in the at-risk mental state using graph theory ', NeuroImage, vol. 56, pp. 1531-1539 . https://doi.org/10.1016/j.neuroimage.2011.02.012

The onset of positive symptoms in schizophrenia is often preceded by a prodromal phase characterized by neurocognitive abnormalities as well as changes in brain structure and function. Increasing efforts have been made to identify individuals at elev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e995ecb8db982e7994c1927449342433
https://doi.org/10.1016/j.neuroimage.2011.02.012

Glutamate NMDA receptor dysregulation in Parkinson’s disease with dyskinesias

Autor: Federico Turkheimer, Gary Hotton, Subrata K. Bose, Imtiaz Ahmed, Nicola Pavese, Anil F. Ramlackhansingh, Alexander Hammers, David J. Brooks

Publikováno v: Ahmed, I, Bose, S K, Pavese, N, Ramlackhansingh, A, Turkheimer, F, Hotton, G, Hammers, A & Brooks, D J 2011, ' Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias ', Brain, vol. 134, no. Pt 4, pp. 979-86 . https://doi.org/10.1093/brain/awr028

Levodopa-induced dyskinesias are a common complication of long-term therapy in Parkinson's disease. Although both pre- and post-synaptic mechanisms seem to be implicated in their development, the precise physiopathology of these disabling involuntary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abeae5f91b1d57c016e7409a174f1871
https://doi.org/10.1093/brain/awr028