Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Subramanya N.M. Pandruvada"'
Autor:
Subramanya N.M. Pandruvada, Jean Vacher, Monica Pata, Suzanne Benjannet, Nabil G. Seidah, Claude Lazure, Janie Beauregard
In humans and in mice, mutations in the Ostm1 gene cause the most severe form of osteopetrosis, a major bone disease, and neuronal degeneration, both of which are associated with early death. To gain insight into Ostm1 function, we first investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e0161d491b40fb9612b1b6d6c021b7
https://europepmc.org/articles/PMC4719428/
https://europepmc.org/articles/PMC4719428/
Autor:
Monica Pata, Manfred W. Kilimann, Jean Vacher, Adam Griffiths, Céline Héraud, Subramanya N.M. Pandruvada
Publikováno v:
The Journal of biological chemistry. 289(20)
Loss of Ostm1 leads to the most severe form of osteopetrosis in mice and humans. Because functional rescue of the osteopetrotic defect in these mice extended their lifespan from ∼3 weeks to 6 weeks, this unraveled a second essential role of Ostm1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebb04ab790efbfaed150887ce235f51
https://pubmed.ncbi.nlm.nih.gov/24719316
https://pubmed.ncbi.nlm.nih.gov/24719316
