Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Subramanian Marappan"'
Autor:
Wei Liu, Naoki Iwamoto, Subramanian Marappan, Khoa Luu, Snehlata Tripathi, Erin Purcell-Estabrook, Juili Dilip Shelke, Himali Shah, Anthony Lamattina, Qianli Pan, Brett Schrand, Frank Favaloro, Mugdha Bedekar, Arindom Chatterjee, Jigar Desai, Tomomi Kawamoto, Genliang Lu, Jake Metterville, Milinda Samaraweera, Priyanka Shiva Prakasha, Hailin Yang, Yuan Yin, Hui Yu, Paloma H Giangrande, Michael Byrne, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 51:4126-4147
Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f52fce2dc6c2c20d3fb621264918bd6b
https://doi.org/10.1093/nar/gkad268
https://doi.org/10.1093/nar/gkad268
Autor:
Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Karley Bussow, Michael Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, Jigar Desai, Frank Favaloro, Jack Godfrey, Andrew Hoss, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Amber Lindsey, Fangjun Liu, Richard Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, Bijay Bhattarai, Stephany Standley, Snehlata Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, Luciano H. Apponi, Pachamuthu Kandasamy, Chandra Vargeese
Publikováno v:
Nature Biotechnology. 40:1093-1102
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to specific cellular RNAs have therapeutic potential, but translating them from cell culture into animal models has been challenging. Here we describe short, chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e36a5ee2c78d18679d808cc838638dd
https://doi.org/10.1038/s41587-022-01225-1
https://doi.org/10.1038/s41587-022-01225-1
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Publikováno v:
Langmuir. 16:6763-6765
A “poly-bolyte” containing 11 C22 chains interconnected by 10 catechol units possessing water-solublizing sulfonate groups was synthesized and studied for its solubility, surface activity, dye adsorption, NMR, dynamic light scattering, electron m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8022aedc303b0ca1cb0545dc139776a1
https://doi.org/10.1021/la0005816
https://doi.org/10.1021/la0005816
Autor:
Philip R. Buzby, Suhaib Siddiqi, Peter McInerney, Kathleen E. Steinmann, Edyta Krzymanska-Olejnik, Jayson Bowers, John F. Thompson, Doron Lipson, Subramanian Marappan, J. William Efcavitch, Judith Mitchell, Marie Causey, Mirna Jarosz, Atanu Roy, Adam R. Platt, Eric Beer, Geoffrey M Lowman, Li Kung
Publikováno v:
Nature methods
Nucleotide analogs modified with a free 3′ hydroxyl, maintaining the interactions at the polymerase active site, and a cleavable linker, attaching a fluorescent dye and an inhibitor, are efficient at reading homopolymer runs in a single-molecule se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2508d6e90b8cd3cee37d4c2c9acf1476
https://pubmed.ncbi.nlm.nih.gov/19620973
https://pubmed.ncbi.nlm.nih.gov/19620973
Autor:
Suhaib Siddiqi, Subramanian Marappan, Rolf Muller, Hubert Köster, Ping Yip, Peng Luan, Daniel P Little
Publikováno v:
Assay and drug development technologies. 5(3)
One of the major hurdles in the post-genomic era is to understand the function of genes and the interplay of many different cellular proteins. This is especially important for drug development. Capture compound mass spectrometry (CCMS) addresses this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b399ce25b37f15a3daa1c6d5341198
https://pubmed.ncbi.nlm.nih.gov/17638538
https://pubmed.ncbi.nlm.nih.gov/17638538
Autor:
Hubert Köster, Daniel P. Little, Peng Luan, Rolf Muller, Suhaib M. Siddiqi, Subramanian Marappan, Ping Yip
Publikováno v:
Assay & Drug Development Technologies; Jun2007, Vol. 5 Issue 3, p381-390, 10p
Autor:
Bhattacharya, Santanu sb@orgchem.iisc.ernet.in, Subramanian, Marappan1
Publikováno v:
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2002, Vol. 43 Issue 23, p4203. 4p.
Sphingomyelinase Induces Lipid Microdomain Formation in a Fluid Phosphatidylcholine/Sphingomyelin...
Publikováno v:
Biochemistry; 12/15/98, Vol. 37 Issue 50, p17562, 9p, 8 Graphs