Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Subramaniam Krishnananthan"'
Autor:
James Kempson, Xiaoping Hou, Jung-Hui Sun, Michael Wong, Joseph Pawluczyk, Jianqing Li, Subramaniam Krishnananthan, Eric M. Simmons, Yi Hsiao, Yi-Xin Li, Dawn Sun, Dauh-Rurng Wu, Wei Meng, Saleem Ahmad, Lidet Negash, Robert Brigance, Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Pratik Devasthale, Jeffrey A. Robl, Arvind Mathur
Publikováno v:
Organic Process Research & Development. 26:1327-1335
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35fda97669790a07bfdfb80a55523b6b
https://doi.org/10.1021/acs.oprd.2c00036
https://doi.org/10.1021/acs.oprd.2c00036
Autor:
Jianqing Li, Daniel Smith, Joseph Pawluczyk, Subramaniam Krishnananthan, Bei Wang, Xiaoping Hou, Rulin Zhao, James Kempson, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Nageswararao Maddala, Muthalagu Vetrichelvan, Anuradha Gupta, John E. Macor, Carolyn D. Dzierba, Arvind Mathur
Publikováno v:
Organic Process Research & Development. 26:437-446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a19c3388a6191ae5b39884a54b5753bd
https://doi.org/10.1021/acs.oprd.1c00452
https://doi.org/10.1021/acs.oprd.1c00452
Autor:
Brian J. Murphy, Daniel Smith, Julia Sapuppo, Giridhar S. Tirucherai, Lawrence J. Kennedy, Ching-Hsuen Chu, Anthony V. Azzara, Shiwei Tao, Glenn D. Rosen, Subramaniam Krishnananthan, Jun Li, Victor R. Guarino, Lisa Burns, Joseph R. Taylor, Milinda Ziegler, Lakshmi Sivaraman, Bruce A. Ellsworth, Selvakumar Kumaravel, Hao Zhang, Tao Wang, Jun Shi, Atsu Apedo, Dhanusu Suresh, Kathy Mosure, Gerry Everlof, David A. Gordon, Lisa Zhang, Michael Gill, Chen-Pin Hung, Jianqing Li, Peter T. W. Cheng, Robert F. Kaltenbach, Sutjano Jusuf, Ying Wang, Stephanie Boehm, Mary Ellen Cvijic, Matthew G. Soars, Chi Shing Sum, Yan Shi, Jeffrey A. Robl, Reddigunta Ramesh Babu, Bradley A. Zinker, Yanou Yang, Stephen S. Kalinowski, Carrie Xu, Steven J. Walker, Sarah C. Traeger, Rebekah Heiry, Kimberley A. Lentz, Qian Ruan
Publikováno v:
Journal of Medicinal Chemistry. 64:15549-15581
The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1 (LPA1) antagonist, with a human LPA1 Kb of 6.9 nM. The structure-activity relationship (SAR) studies starting from the LPA1 antagonist clinical compound BMS-986020 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c00ce908946d21bafba2486eb2e08c90
https://doi.org/10.1021/acs.jmedchem.1c01256
https://doi.org/10.1021/acs.jmedchem.1c01256
Autor:
Dauh-Rurng Wu, Joseph Pawluczyk, Robert J. Cherney, Joseph A. Tino, Shiuhang Yip, T. G. Murali Dhar, James Kempson, Jianqing Li, Darpandeep Aulakh, Amy A. Sarjeant, Daniel Smith, Arvind Mathur, Cornelius Lyndon A M, Subramaniam Krishnananthan
Publikováno v:
The Journal of Organic Chemistry. 85:10988-10993
We describe an efficient synthetic route to differentially protected diester, 1-(tert-butyl) 4-methyl (1R,2S,4R)-2-methylcyclohexane-1,4-dicarboxylate (+)-1, via palladium-catalyzed methoxycarbonylation of an enol triflate derived from a Hagemann's e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fba5ca413d795699a30093fecc6e060
https://doi.org/10.1021/acs.joc.0c01169
https://doi.org/10.1021/acs.joc.0c01169
Publikováno v:
Organic Process Research & Development. 24:1157-1163
An efficient scale-up synthesis of 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(1-(pyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)benzofuran-3-carboxamide (BMS-929075), an allosteric, palm site ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60acf3837b1b97b50f173e802e5a14f0
https://doi.org/10.1021/acs.oprd.0c00198
https://doi.org/10.1021/acs.oprd.0c00198
Publikováno v:
Organic Process Research & Development. 24:454-458
N-(4-(3-(6-(Difluoromethyl)pyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl)pyridin-2-yl)acetamide (5) is a potent inhibitor of TGFβRI kinase that provides durable antitumor activity when combined with ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e5941395c4e3d44b4283f4160f7b5e
https://doi.org/10.1021/acs.oprd.0c00015
https://doi.org/10.1021/acs.oprd.0c00015
Autor:
Peter T W, Cheng, Robert F, Kaltenbach, Hao, Zhang, Jun, Shi, Shiwei, Tao, Jun, Li, Lawrence J, Kennedy, Steven J, Walker, Yan, Shi, Ying, Wang, Suresh, Dhanusu, Ramesh, Reddigunta, Selvakumar, Kumaravel, Sutjano, Jusuf, Daniel, Smith, Subramaniam, Krishnananthan, Jianqing, Li, Tao, Wang, Rebekah, Heiry, Chi Shing, Sum, Stephen S, Kalinowski, Chen-Pin, Hung, Ching-Hsuen, Chu, Anthony V, Azzara, Milinda, Ziegler, Lisa, Burns, Bradley A, Zinker, Stephanie, Boehm, Joseph, Taylor, Julia, Sapuppo, Kathy, Mosure, Gerry, Everlof, Victor, Guarino, Lisa, Zhang, Yanou, Yang, Qian, Ruan, Carrie, Xu, Atsu, Apedo, Sarah C, Traeger, Mary Ellen, Cvijic, Kimberley A, Lentz, Giridhar, Tirucherai, Lakshmi, Sivaraman, Jeffrey, Robl, Bruce A, Ellsworth, Glenn, Rosen, David A, Gordon, Matthew G, Soars, Michael, Gill, Brian J, Murphy
Publikováno v:
Journal of medicinal chemistry. 64(21)
The oxycyclohexyl acid BMS-986278 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80069106f38ceb56aa2828cf9bc68357
https://pubmed.ncbi.nlm.nih.gov/34709814
https://pubmed.ncbi.nlm.nih.gov/34709814
Autor:
Karen A. Rossi, Ruth R. Wexler, Steven Sheriff, Dawn Sun, Jeffrey M. Bozarth, Jianqing Li, Elizabeth A. Dierks, James R. Corte, Yiming Wu, Donald J. P. Pinto, Silvi A. Chacko, Michael Galella, Joanna J. Zheng, Joseph E. Myers, Dauh-Rurng Wu, Tianan Fang, Joseph M. Luettgen, Pancras C. Wong, Xiaoping Hou, Pabbisetty Kumar Balashanmuga, Daniel Smith, Indawati De Lucca, Huiping Zhang, Wu Yang, Arvind Mathur, Yufeng Wang, Dilger Andrew K, William R. Ewing, Subramaniam Krishnananthan, Yeheng Zhu, Earl J. Crain, Theresa Ziemba
Publikováno v:
Journal of medicinal chemistry. 65(3)
Factor XIa (FXIa) is an enzyme in the coagulation cascade thought to amplify thrombin generation but has a limited role in hemostasis. From preclinical models and human genetics, an inhibitor of FXIa has the potential to be an antithrombotic agent wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf4f1ea39b0f4f590f90003f6f693cc
https://pubmed.ncbi.nlm.nih.gov/34494428
https://pubmed.ncbi.nlm.nih.gov/34494428
Autor:
John E. Macor, Yunhui Zhang, James E. Grace, Lorin A. Thompson, Jeremy H. Toyn, Lawrence R. Marcin, Subramaniam Krishnananthan, Jianliang Shi, Dmitry Zuev, Daniel Smith, Jianqing Li, Yong-Jin Wu, Jason M. Guernon, Xiaoliang Zhuo, Tatyana Zvyaga, Xu Li, Arvind Mathur, John Morrison, Jere E. Meredith, Charles F. Albright, S. Roy Kimura, Mendi A. Higgins, Kimberley A. Lentz, Richard E. Olson, Rex Denton, Kenneth M. Boy, Catherine R. Burton, Ashok K. Trehan, Michael K. Ahlijanian
Publikováno v:
ACS Medicinal Chemistry Letters
A triazine hit identified from a screen of the BMS compound collection was optimized for potency, in vivo activity, and off-target profile to produce the bicyclic pyrimidine γ-secretase modulator BMS-932481. The compound showed robust reductions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed62d494eee5e78e1c6f0f7838951135
http://europepmc.org/articles/PMC6421538
http://europepmc.org/articles/PMC6421538
Autor:
Lyndon A M, Cornelius, Jianqing, Li, Daniel, Smith, Subramaniam, Krishnananthan, Shiuhang, Yip, Dauh-Rurng, Wu, Joseph, Pawluczyk, Darpandeep, Aulakh, Amy A, Sarjeant, James, Kempson, Joseph A, Tino, Arvind, Mathur, T G, Murali Dhar, Robert J, Cherney
Publikováno v:
The Journal of organic chemistry. 85(16)
We describe an efficient synthetic route to differentially protected diester, 1-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df07183df8f1f4be77277c2b6f15bcdc
https://pubmed.ncbi.nlm.nih.gov/32687358
https://pubmed.ncbi.nlm.nih.gov/32687358