Výsledky vyhledávání - "Subramaniam, Krishnan"

Akademický článek

Sepsis endotypes identified by host gene expression across global cohorts

Publikováno v: Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)

Abstract Background Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address complicating heterogeneity in sepsis pathobiology, and improve outcomes, promising precis

Externí odkaz: https://doaj.org/article/c20dbc2d922941d3a99c931cb0e51535

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Akademický článek

Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis

Externí odkaz: https://doaj.org/article/81d492ccfe114c88a466b6acdd447d0a

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Akademický článek

Jammed joints and constricted heart: The science of tribology and missing lubricin. A case report on camptodactyly-arthropathy coxa vara-pericarditis syndrome.

Autor: Subramaniam, Krishnan Ganapathy¹, Mohanty, Satish², Sharma, Dhruva³ drsharmadhruva1981@gmail.com, Tamildasan, Komal¹, Reddy, Narahari Srinath²

Publikováno v: Annals of Pediatric Cardiology. May/Jun2024, Vol. 17 Issue 3, p221-223. 3p.

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Akademický článek

Screening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study

Publikováno v: BMJ Open, Vol 13, Iss 2 (2023)

Objectives We evaluated the performance of commonly used sepsis screening tools across prospective sepsis cohorts in the USA, Cambodia and Ghana.Design Prospective cohort studies.Setting and participants From 2014 to 2021, participants with two or mo

Externí odkaz: https://doaj.org/article/985bdbc4adde4301b1d31e95179451ca

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Akademický článek

An approach to rapidly assess sepsis through multi-biomarker host response using machine learning algorithm

Autor: Abha Umesh Sardesai, Ambalika Sanjeev Tanak, Subramaniam Krishnan, Deborah A. Striegel, Kevin L. Schully, Danielle V. Clark, Sriram Muthukumar, Shalini Prasad

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Sepsis is a life-threatening condition and understanding the disease pathophysiology through the use of host immune response biomarkers is critical for patient stratification. Lack of accurate sepsis endotyping impedes clinicians from making

Externí odkaz: https://doaj.org/article/770683cc8bca41dfbf6c5f85c3491587

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Akademický článek

Multiplexed host immune response biosensor for rapid sepsis stratification and endotyping at point-of-care

Autor: Ambalika S. Tanak, Abha Sardesai, Sriram Muthukumar, Subramaniam Krishnan, Deborah A. Striegel, Kevin L. Schully, Danielle V. Clark, Shalini Prasad

Publikováno v: Biosensors and Bioelectronics: X, Vol 10, Iss , Pp 100144- (2022)

Disease progression of sepsis has been perceived as a multifaceted phenomenon, considering the temporal host inflammatory response within individuals which requires early diagnosis. Herein, we present a multicohort analysis through temporal inflammat

Externí odkaz: https://doaj.org/article/ceee8d29377644449602f51470a87c48

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Akademický článek

Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients.

Autor: Joost Brandsma, Josh G Chenoweth, Melissa K Gregory, Subramaniam Krishnan, Paul W Blair, Deborah A Striegel, Rittal Mehta, Kevin L Schully, J Stephen Dumler, Cdr Cynthia S Sikorski, Kelsey O'Connor, Susan A Reichert-Scrivner, Carmen M Paguirigan, Catherine F T Uyehara, Col Viseth Ngauy, Christopher A Myers, Danielle V Clark

Publikováno v: PLoS ONE, Vol 17, Iss 8, p e0272572 (2022)

BackgroundVenous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self

Externí odkaz: https://doaj.org/article/9ab084dd987146e1ae97ef249231302c

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