Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Subir R. Maitra"'
Publikováno v:
Academic Emergency Medicine. 12:797-803
Objectives Hemorrhage initiates an inflammatory response that induces the systemic release of cytokines and sequestration of polymorphonuclear neutrophils. Sequestered polymorphonuclear neutrophils release proteases, including matrix metalloproteinas
Publikováno v:
Critical Care Medicine. 33:1577-1581
Objectives We have previously demonstrated that hepatic matrixmetalloproteinase (MMP)-9 and gelatinase activity increased significantly after sepsis, and pretreatment with chemically modified tetracycline (CMT-3) inhibited these expressions and impro
Regulation of Liver and Kidney Glucose-6-phosphatase Gene Expression in Hemorrhage and Resuscitation
Publikováno v:
Academic Emergency Medicine. 7:731-738
UNLABELLED The authors have recently demonstrated that increased gene expression of glucose-6-phosphatase (Glu-6-Pase) in hemorrhagic hypotension (HH) and following lactated Ringer's resuscitation (LR) is associated with a decrease in insulin and an
Publikováno v:
Academic Emergency Medicine. 6:588-595
OBJECTIVE The metabolic alterations observed during sepsis may be associated with changes in local concentrations of intracellular calcium (Ca2+) and prostanoid synthesis in the liver. The authors studied hepatocyte intracellular Ca2+ and the release
Publikováno v:
Journal of Surgical Research. 55:201-204
Endotoxic shock is associated with profound metabolic alterations including hypoglycemia and hyperlactiacidemia. We studied hepatic glucose production and the role of diltiazem in affecting these metabolic alterations in a rat model of endotoxic shoc
Autor:
Subir R. Maitra, G.T. Tortora, Evan R. Geller, James Maurer, P. R. Kennedy, Scott A. Dulchavsky
Publikováno v:
The Journal of Trauma: Injury, Infection, and Critical Care. 31:991-995
Fibrin glue is an effective hemostatic agent in a variety of clinical situations; its utility is limited by potential transmission of viral infection. We studied the bactericidal properties of fibrin gel (FG) in a murine contaminated hepatic injury m
Publikováno v:
International Journal of Molecular Medicine.
We recently demonstrated that the hepatic cytochrome P-450 (CYP) isoform 1A2 is downregulated in sepsis, which appears to play an important role in the inflammatory response and liver injury. However, the mechanism responsible for the decreased CYP1A
Publikováno v:
Molecular medicine (Cambridge, Mass.). 13(9-10)
Downregulation of vascular endothelial constitutive nitric oxide synthase (ecNOS) contributes to the vascular hyporesponsiveness in sepsis. Although coadministration of the potent vasodilatory peptide adrenomedulin (AM) and the newly discovered AM bi
Autor:
Timo Sorsa, Patrick D. Valane, Sikha Bhaduri, Subir R. Maitra, Nungavarm S. Ramamurthy, Taina Tervahartiala
Publikováno v:
Shock (Augusta, Ga.). 20(3)
Sepsis precipitates a systemic inflammatory stimulus that causes systemic release of cytokines and sequestration of polymorphonuclear neutrophils, resulting in degranulation of matrix metalloproteinases (MMPs), which causes extracellular matrix basem
Publikováno v:
Shock (Augusta, Ga.). 14(5)
To assess the role of glucocorticoid receptor antagonists and mediators released by Kupffer cells and other resident macrophages, we have used RU486 and gadolinium chloride to prevent the induction of glucose-6-phosphatase (Glu-6-Pase) gene expressio