Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Subhrajit Rout"'
Autor:
Erkin Kuru, Jonathan Rittichier, Helena de Puig, Allison Flores, Subhrajit Rout, Isaac Han, Abigail E. Reese, Thomas M. Bartlett, Fabio De Moliner, Sylvie G. Bernier, Jason D. Galpin, Jorge Marchand, William Bedell, Lindsey Robinson-McCarthy, Christopher A. Ahern, Thomas G. Bernhardt, David Z. Rudner, James J. Collins, Marc Vendrell, George M. Church
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Binding-activated optical sensors are powerful tools for imaging, diagnostics, and biomolecular sensing. However, biosensor discovery is slow and requires tedious steps in rational design, screening, and characterization. Here we report on a
Externí odkaz:
https://doaj.org/article/8c008f8b3019484da6521bb74160e592
Autor:
Subhrajit Rout, Kyriacos C. Nicolaou, Baiwei Lin, Marybeth Pysz, Emmanuel N. Pitsinos, Hanan Fernando, Christina E. Lee, Anukriti Dhar, Joseph Sandoval, Yong Lu, Stephan Rigol, Monette Aujay, Dane Holte, Nicole Taylor, Hetal Sarvaiya, Amanda M. Valdiosera, Dipendu Das, Alexander Schammel, Christine Gu, Julia Gavrilyuk, Holger Karsunky, Jose Trinidad, Nicole Barbour
Publikováno v:
Proc Natl Acad Sci U S A
Significance A number of antibody–drug conjugates (ADCs) with varying linkers carrying an uncialamycin analogue as payload were synthesized and tested for their cytotoxicity in vitro and in PDX mouse models. Importantly, a number of these enediyne-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41af35fc07d687d65be0c83371cbaf4
https://pubmed.ncbi.nlm.nih.gov/34155147
https://pubmed.ncbi.nlm.nih.gov/34155147
Autor:
Julia Gavrilyuk, Mikhail Hammond, Subhrajit Rout, Yong Lu, Monette Aujay, Kyriacos C. Nicolaou, Joseph Sandoval, Emmanuel N. Pitsinos, Dipendu Das, Joseph Lyssikatos, Alexander Schammel
Publikováno v:
Journal of the American Chemical Society. 142(5)
The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimyci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b660907f744160d7bf15f85afc7a5cb5
https://pubmed.ncbi.nlm.nih.gov/31976660
https://pubmed.ncbi.nlm.nih.gov/31976660
Publikováno v:
Chemical Communications. 53:5143-5146
A highly diastereo- and enantioselective vinylogous Mukaiyama-Michael reaction of silyloxyfurans with α,β-unsaturated 2-acyl imidazoles catalyzed by either chiral Sc(iii) or Er(iii) complexes of a pybox ligand has been reported. The enantioenriched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bf46f9c18ee830a9bf5e1eacd3612c
https://doi.org/10.1039/c7cc01763d
https://doi.org/10.1039/c7cc01763d
Publikováno v:
Tetrahedron. 76:130800
An enantioselective catalytic sulfa-Michael addition of alkyl thiols to α,β-unsaturated 2-acyl imidazoles using bifunctional organocatalysts is reported. The methodology works efficiently with low catalyst loading (1 mol%) to furnish sulfa-Michael
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae5a5f14247860d9a272facb6d347a09
https://doi.org/10.1016/j.tet.2019.130800
https://doi.org/10.1016/j.tet.2019.130800
Publikováno v:
The Journal of organic chemistry. 83(9)
Metal-directed switching of enantioselectivity in the Mukaiyama–Michael reaction of silyl enol ethers to α,β-unsaturated 2-acyl imidazoles using the same chiral indapybox ligand has been reported. The utility of this approach has been portrayed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bf1bfd06cd38a89120a69c207b98e9
https://pubmed.ncbi.nlm.nih.gov/29658718
https://pubmed.ncbi.nlm.nih.gov/29658718
Publikováno v:
Organic letters. 20(8)
An asymmetric direct doubly vinylogous Michael addition has been developed for the generation of sterically congested vicinal quaternary and tertiary stereocenters. This doubly vinylogous Michael addition of β,γ-unsaturated butenolides to 3-methyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd1ae5797849e3f4454d17c5ed7b1ab
https://pubmed.ncbi.nlm.nih.gov/30382702
https://pubmed.ncbi.nlm.nih.gov/30382702
Publikováno v:
Organic Letters. 16:5568-5571
Catalytic enantioselective direct vinylogous Michael addition of α,α-dicyanoalkenes to 2-enoylpyridine N-oxides with a bifunctional organocatalyst is described. The methodology offers an efficient way to install an asymmetric carbon-carbon bond at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94fcc3601c5485a1ca78e1b68b13d29
https://doi.org/10.1021/ol5025794
https://doi.org/10.1021/ol5025794
Publikováno v:
Organic Letters. 20:7351-7351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08c6987063a78d875475cad5f92638f
https://doi.org/10.1021/acs.orglett.8b03370
https://doi.org/10.1021/acs.orglett.8b03370
Publikováno v:
ChemInform. 46
Catalytic enantioselective direct vinylogous Michael addition of α,α-dicyanoalkenes to 2-enoylpyridine N-oxides with a bifunctional organocatalyst is described. The methodology offers an efficient way to install an asymmetric carbon–carbon bond a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f090340bcc9cf04402cadb5bc83c5152
https://doi.org/10.1002/chin.201515032
https://doi.org/10.1002/chin.201515032