Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Subhiksha Nandakumar"'
Autor:
Sai Harisha Rajanala, Romina Ghale, Subhiksha Nandakumar, Kalyani Chadalavada, Gwo-Shu Mary Lee, Konrad H Stopsack, Yu Chen, Gouri J Nanjangud, Goutam Chakraborty, Philip W Kantoff
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301989 (2024)
Somatic Y chromosome loss in hematopoietic cells is associated with higher mortality in men. However, the status of the Y chromosome in cancer tissue is not fully known due to technical limitations, such as difficulties in labelling and sequencing DN
Externí odkaz:
https://doaj.org/article/9f025f8d20d746c0a246657541807f95
Autor:
Yuki Yoshikawa, Konrad H. Stopsack, Xin Victoria Wang, Yu‐Hui Chen, Ying Z. Mazzu, Foster Burton, Goutam Chakraborty, Sai Harisha Rajanala, Rahim Hirani, Subhiksha Nandakumar, Gwo‐Shu Mary Lee, David Frank, Elai Davicioni, Glenn Liu, Michael A. Carducci, Haruhito Azuma, Philip W. Kantoff, Christopher J. Sweeney
Publikováno v:
Molecular Oncology, Vol 16, Iss 22, Pp 3994-4010 (2022)
Loss of the histone demethylase KDM5D (lysine‐specific demethylase 5D) leads to in vitro resistance of prostate cancer cells to androgen deprivation therapy (ADT) with and without docetaxel. We aimed to define downstream drivers of the KDM5D effect
Externí odkaz:
https://doaj.org/article/f3e5c6df0fe14e4b96ddc7e70c0635e6
Autor:
Lee Shaashua, Aviad Ben-Shmuel, Meirav Pevsner-Fischer, Gil Friedman, Oshrat Levi-Galibov, Subhiksha Nandakumar, Debra Barki, Reinat Nevo, Lauren E. Brown, Wenhan Zhang, Yaniv Stein, Chen Lior, Han Sang Kim, Linda Bojmar, William R. Jarnagin, Nicolas Lecomte, Shimrit Mayer, Roni Stok, Hend Bishara, Rawand Hamodi, Ephrat Levy-Lahad, Talia Golan, John A. Porco, Christine A. Iacobuzio-Donahue, Nikolaus Schultz, David A. Tuveson, David Lyden, David Kelsen, Ruth Scherz-Shouval
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Cancer-associated fibroblasts are transcriptionally rewired by signals from the cancer cells, resulting in heterogeneous populations. Here the authors show that loss of BRCA function in pancreatic cancer cells leads to HSF1–dependent accumulation o
Externí odkaz:
https://doaj.org/article/ace9d26882394fbe81d1eae2056e5de9
Autor:
Ying Z. Mazzu, YuRou Liao, Subhiksha Nandakumar, Martin Sjöström, Lina E. Jehane, Romina Ghale, Barani Govindarajan, Travis A. Gerke, Gwo‐Shu Mary Lee, Jian‐Hua Luo, Sreenivasa R. Chinni, Lorelei A. Mucci, Felix Y. Feng, Philip W. Kantoff
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2451-2469 (2022)
Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2
Externí odkaz:
https://doaj.org/article/1e7d977b030b44b383eed28d4cf9959d
Autor:
Ying Z. Mazzu, Joshua Armenia, Subhiksha Nandakumar, Goutam Chakraborty, Yuki Yoshikawa, Lina E. Jehane, Gwo‐Shu Mary Lee, Mohammad Atiq, Nabeela Khan, Nikolaus Schultz, Philip W. Kantoff
Publikováno v:
Molecular Oncology, Vol 14, Iss 8, Pp 1881-1897 (2020)
Although there are molecularly distinct subtypes of prostate cancer, no molecular classification system is used clinically. The ribonucleotide reductase small subunit M2 (RRM2) gene plays an oncogenic role in many cancers. Our previous study elucidat
Externí odkaz:
https://doaj.org/article/a67bfa99d1ad45d6a66edcca61774047
Autor:
Ying Z. Mazzu, Yuki Yoshikawa, Subhiksha Nandakumar, Goutam Chakraborty, Joshua Armenia, Lina E. Jehane, Gwo‐Shu Mary Lee, Philip W. Kantoff
Publikováno v:
Molecular Oncology, Vol 13, Iss 9, Pp 1944-1958 (2019)
Epigenetic silencing of miRNA is a primary mechanism of aberrant miRNA expression in cancer, and hypermethylation of miRNA promoters has been reported to contribute to prostate cancer initiation and progression. Recent data have shown that the miR‐
Externí odkaz:
https://doaj.org/article/68afe51bc4754a7eaf9d362267c6ab6a
Publikováno v:
Viruses, Vol 12, Iss 4, p 403 (2020)
African green monkey (AGM) spumaretroviruses have been less well-studied than other simian foamy viruses (SFVs). We report the biological and genomic characterization of SFVcae_FV2014, which was the first foamy virus isolated from an African green mo
Externí odkaz:
https://doaj.org/article/95bbf0741fa9403fa0f4e3ab1cc61dc1
Publikováno v:
mSphere, Vol 3, Iss 2 (2018)
ABSTRACT Detection of distantly related viruses by high-throughput sequencing (HTS) is bioinformatically challenging because of the lack of a public database containing all viral sequences, without abundant nonviral sequences, which can extend runtim
Externí odkaz:
https://doaj.org/article/39ec26834cea474a9ecfb828cd3ab3ee
Autor:
Yuki Yoshikawa, Konrad H. Stopsack, Xin Victoria Wang, Yu‐Hui Chen, Ying Z. Mazzu, Foster Burton, Goutam Chakraborty, Sai Harisha Rajanala, Rahim Hirani, Subhiksha Nandakumar, Gwo‐Shu Mary Lee, David Frank, Elai Davicioni, Glenn Liu, Michael A. Carducci, Haruhito Azuma, Philip W. Kantoff, Christopher J. Sweeney
Publikováno v:
Molecular Oncology. 16:3994-4010
Loss of the histone demethylase KDM5D (lysine-specific demethylase 5D) leads to in vitro resistance of prostate cancer cells to androgen deprivation therapy (ADT) with and without docetaxel. We aimed to define downstream drivers of the KDM5D effect.
Autor:
Kanika Arora, Thinh N. Tran, Yelena Kemel, Miika Mehine, Ying L. Liu, Subhiksha Nandakumar, Shaleigh A. Smith, A. Rose Brannon, Irina Ostrovnaya, Konrad H. Stopsack, Pedram Razavi, Anton Safonov, Hira A. Rizvi, Matthew D. Hellmann, Joseph Vijai, Thomas C. Reynolds, James A. Fagin, Jian Carrot-Zhang, Kenneth Offit, David B. Solit, Marc Ladanyi, Nikolaus Schultz, Ahmet Zehir, Carol L. Brown, Zsofia K. Stadler, Debyani Chakravarty, Chaitanya Bandlamudi, Michael F. Berger
Publikováno v:
Cancer Discov
Accurate ancestry inference is critical for identifying genetic contributors of cancer disparities among populations. Although methods to infer genetic ancestry have historically relied upon genome-wide markers, the adaptation to targeted clinical se