Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Subhashis, Jana"'
Autor:
Duk-Su Koh, Anastasiia Stratiievska, Subhashis Jana, Shauna C Otto, Teresa M Swanson, Anthony Nhim, Sara Carlson, Marium Raza, Ligia Araujo Naves, Eric N Senning, Ryan A Mehl, Sharona E Gordon
Publikováno v:
eLife, Vol 12 (2024)
Ligands such as insulin, epidermal growth factor, platelet-derived growth factor, and nerve growth factor (NGF) initiate signals at the cell membrane by binding to receptor tyrosine kinases (RTKs). Along with G-protein-coupled receptors, RTKs are the
Externí odkaz:
https://doaj.org/article/4da9d7ab97974baea2685bfc3abbcc20
Autor:
Subhashis Jana, Eric G. B. Evans, Hyo Sang Jang, Shuyang Zhang, Hui Zhang, Andrzej Rajca, Sharona E. Gordon, William N. Zagotta, Stefan Stoll, Ryan A. Mehl
Publikováno v:
bioRxiv
Studying protein structures and dynamics directly in the cellular environments in which they function is essential to fully understand the molecular mechanisms underlying cellular processes. Site-directed spin-labeling (SDSL)—in combination with do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92a84e92edd5c1de181579c16ce6f1a
https://doi.org/10.1101/2023.01.26.525763
https://doi.org/10.1101/2023.01.26.525763
Autor:
Savanna, Avila-Crump, Marcus L, Hemshorn, Chloe M, Jones, Lea, Mbengi, Kyle, Meyer, Joshua A, Griffis, Subhashis, Jana, Grace E, Petrina, Vinayak V, Pagar, P Andrew, Karplus, E James, Petersson, John J, Perona, Ryan A, Mehl, Richard B, Cooley
Publikováno v:
ACS chemical biology. 17(12)
Genetic code expansion (GCE) technologies commonly use the pyrrolysyl-tRNA synthetase (PylRS)/tRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af6e02321884d3130d15c09b8a7410dd
https://pubmed.ncbi.nlm.nih.gov/36383641
https://pubmed.ncbi.nlm.nih.gov/36383641
Autor:
Elise M. Van Fossen, Riley M. Bednar, Subhashis Jana, Rachel Franklin, Joseph Beckman, P. Andrew Karplus, Ryan A. Mehl
Publikováno v:
Science Advances. 8
Assembling nanobodies (Nbs) into polyvalent multimers is a powerful strategy for improving the effectiveness of Nb-based therapeutics and biotechnological tools. However, generally effective approaches to Nb assembly are currently restricted to the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1035c28f8c37405687071db12a0a1c7
https://doi.org/10.1126/sciadv.abm6909
https://doi.org/10.1126/sciadv.abm6909
Autor:
Byungseop Yang, Seoungkyun Kim, Ryan A. Mehl, Kiyoon Kwon, Giyoong Tae, Subhashis Jana, Inchan Kwon, Savanna Avila-Crump
Publikováno v:
Bioconjugate Chemistry. 31:2456-2464
An inverse-electron-demand Diels-Alder (IEDDA) reaction using genetically encoded tetrazine variants enables rapid bioconjugation for diverse applications in vitro and in cellulo. However, in vivo bioconjugation using genetically encoded tetrazine va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ffde5015af2ce818cd28e96766fc14
https://doi.org/10.1021/acs.bioconjchem.0c00497
https://doi.org/10.1021/acs.bioconjchem.0c00497
Publikováno v:
J Am Chem Soc
Labeling of biomolecules in live eukaryotic cells has been limited by low component stability and slow reaction rates. We show that genetically encoded tetrazine amino acids in proteins reach reaction rates of 8×10(4) M(−1)s(−1) with sTCO reagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405193934dc2050ca20f648912727da1
https://doi.org/10.1021/jacs.9b11520
https://doi.org/10.1021/jacs.9b11520
Autor:
Joseph S. Beckman, Ryan A. Mehl, Rachel Franklin, Edwin Antony, Subhashis Jana, Sahiti Kuppa, Riley M. Bednar, Richard B. Cooley
Publikováno v:
ACS Chem Biol
The ability to site-specifically modify proteins at multiple sites in vivo will enable the study of protein function in its native environment with unprecedented levels of detail. Here, we present a versatile two-step strategy to meet this goal invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8219d7a77abf10fd1f1655c4e4a6403f
https://europepmc.org/articles/PMC9377405/
https://europepmc.org/articles/PMC9377405/
Autor:
Wesley J. Brown, P. Andrew Karplus, Ryan A. Mehl, Riley M. Bednar, Kelsey Kean, Subhashis Jana, Joe E. Baio, Thaddeus W. Golbek
Publikováno v:
ACS Applied Materials & Interfaces. 11:36391-36398
Biomaterials based on immobilized proteins are key elements of many biomedical and industrial technologies. However, applications are limited by an inability to precisely construct materials of high homogeneity and defined content. We present here a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222a7532cef9b156ebf8302b177d44fa
https://doi.org/10.1021/acsami.9b12746
https://doi.org/10.1021/acsami.9b12746
Publikováno v:
Letters in Drug Design & Discovery. 16:417-426
Background: Malaria Parasite relies heavily on signal transduction pathways to control growth, the progression of the life cycle and sustaining stress for its survival. Unlike kinases, Plasmodium's phosphatome is one of the smallest and least explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ef4e04cd63a69fb126975755257bca2
https://doi.org/10.2174/1570180815666180727121200
https://doi.org/10.2174/1570180815666180727121200
Publikováno v:
New Journal of Chemistry. 41:13391-13398
We report a unique fluorescence sensor based on an axially chiral unnatural triazolyl aromatic amino acid scaffold (ArTAA) for discrimination of methanol from ethanol via a switch on fluorescence response. All three sensors, the simple scaffold (ArTA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872226c0f0df23a50633e6c5a056a2d1
https://doi.org/10.1039/c7nj01945a
https://doi.org/10.1039/c7nj01945a