Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Subhash C. Sinha"'
Autor:
Celeste Parra Bravo, Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li, Li Fan, Edwin Vázquez-Rosa, Min-Kyoo Shin, Man Ying Wong, Louise D. McCullough, Ryan S. Kitagawa, H. Alex Choi, Angela Cacace, Subhash C. Sinha, Andrew A. Pieper, Susanna Rosi, Xu Chen, Li Gan
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal lobar degeneration (FTLD), and traumatic brain injury (TBI). Previously, we reported that reducing acetylated ta
Externí odkaz:
https://doaj.org/article/3740b616df0e4c68b196af27d37bdb39
Autor:
Dionnet L. Bhatti, Junghee Jin, Jia Cheng, Kathryn McCabe, Ko-Woon Lee, Clara Berdasco, Yu Young Jeong, Subhash C. Sinha, Yong Kim
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The prefrontal cortex (PFC) is a key neural node mediating behavioral responses to stress and the actions of ketamine, a fast-acting antidepressant. The molecular mechanisms underlying these processes, however, are not fully understood. Our recent st
Externí odkaz:
https://doaj.org/article/845b09bf82bf497e8e027498e00a068f
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in d
Externí odkaz:
https://doaj.org/article/c19a965ed47e49e6bf3579534077e085
Publikováno v:
Heliyon, Vol 3, Iss 1 (2017)
Respiratory Complex I from E. coli may exist in two interconverting forms: resting (R) and active (A). The R/A transition of purified, solubilized Complex I occurring upon turnover was studied employing two different fluorescent probes, Annine 6+, an
Externí odkaz:
https://doaj.org/article/d91b70a5dac441dcb2d33d9e3384ff8b
Autor:
Joe C. Udeochu, Sadaf Amin, Yige Huang, Li Fan, Eileen Ruth S. Torres, Gillian K. Carling, Bangyan Liu, Hugo McGurran, Guillermo Coronas-Samano, Grant Kauwe, Gergey Alzaem Mousa, Man Ying Wong, Pearly Ye, Ravi Kumar Nagiri, Iris Lo, Julia Holtzman, Carlo Corona, Allan Yarahmady, Michael T. Gill, Ravikiran M. Raju, Sue-Ann Mok, Shiaoching Gong, Wenjie Luo, Mingrui Zhao, Tara E. Tracy, Rajiv R. Ratan, Li-Huei Tsai, Subhash C. Sinha, Li Gan
Publikováno v:
Nature Neuroscience. 26:737-750
Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP–AMP synthase (cGAS) diminishes cognitiv
Autor:
Rakesh Sathish Nair, Sandeep Kumar, Subhasis Das, Sunil Kumar Singh, Piush Srivastava, Gautam Sondarva, Arundhati Rao, Subhash C. Sinha, Rui Xiong, Laura Bloem, Kent Hoskins, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana
Publikováno v:
Oncogene. 42:1132-1143
Autor:
Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Matthew Dorman, Subhash C Sinha, Kent Hoskins, Gregory Thatcher, Basabi Rana, Ajay Rana
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The mitogen-activated protein kinases (MAPKs) are important for T cell survival and their effector function. Mixed lineage kinase 3 (MLK3) (MAP3K11) is an upstream regulator of MAP kinases and emerging as a potential candidate for targeted
Externí odkaz:
https://doaj.org/article/a88048066d8f4bf1819a611e152d52ec
Autor:
Victor Hugo Bustos, Yashoda Krishna Sunkari, Anjana Sinha, Maria Pulina, Ashley Bispo, Maya Hopkins, Alison Lam, Sydney F. Kriegsman, Emily Mui, Emily Chang, Ana Jedlicki, Hannah Rosenthal, Marc Flajolet, Paul Greengard, Subhash C. Sinha
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by the accumulation of beta-amyloid (Aβ), C99, and Tau in vulnerable areas of the brain. Despite extensive research, current strategies to lower Aβ levels have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b996c2596047e1f36028280741db2409
https://doi.org/10.1101/2023.04.28.538773
https://doi.org/10.1101/2023.04.28.538773
Autor:
Cheng Liu, Kim D. Janda, Nigel Mackman, Subhash C. Sinha, Longwu Ye, Dong Xue, Katerina Capkova, Pengfei Jiang, Yuan Liu
PDF file - 910K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be976d39bbbd9cf4eb82d9b1ee6f67a
https://doi.org/10.1158/0008-5472.22390826
https://doi.org/10.1158/0008-5472.22390826
Autor:
Cheng Liu, Kim D. Janda, Nigel Mackman, Subhash C. Sinha, Longwu Ye, Dong Xue, Katerina Capkova, Pengfei Jiang, Yuan Liu
Tissue factor (TF), a rate-limiting enzyme cofactor in activating coagulation, is highly expressed in a wide spectrum of human tumor and tumor stromal cells. Using TF-deficient cancer cells and a conditional TF-knockout mouse model, we show that TF e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83bb7f97686b848532fdec7a7250d568
https://doi.org/10.1158/0008-5472.c.6503075.v1
https://doi.org/10.1158/0008-5472.c.6503075.v1