Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Subhas C, Bera"'
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Akademický článek
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective
Autor: Mona Seifert, Subhas C Bera, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris, Flavia S Papini, Jamie J Arnold, Steven Almo, Tyler L Grove, Pei-Yong Shi, Yan Xiang, Bruno Canard, Martin Depken, Craig E Cameron, David Dulin
Publikováno v: eLife, Vol 10 (2021)
The absence of ‘shovel-ready’ anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be r
Externí odkaz: https://doaj.org/article/3f924b912930433ba8d5da28b1275015
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2
Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex
Autor: Misha Klein, Subhas C. Bera, Thomas K. Anderson, Bing Wang, Flavia S. Papini, Jamie J. Arnold, Craig E. Cameron, Martin Depken, Robert N. Kirchdoerfer, Irina Artsimovitch, David Dulin
Publikováno v: Biophysical Journal, 122(3 Supplement 1), 171a-171a. Biophysical Society
Klein, M, Bera, S C, Anderson, T K, Wang, B, Papini, F S, Arnold, J J, Cameron, C E, Depken, M, Kirchdoerfer, R N, Artsimovitch, I & Dulin, D 2023, ' Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex ', Biophysical Journal, vol. 122, no. 3 Supplement 1, pp. 171a-171a . https://doi.org/10.1016/j.bpj.2022.11.1071
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb8339eb4a500aacda2e6045c01b27b
https://research.vu.nl/en/publications/b815bc2f-c880-41dc-a5f6-3840c02196a0
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3
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation
Autor: Sara Linse, Tuomas P. J. Knowles, Subhas C. Bera, Kanchan Garai, Sourav Dasadhikari, Manuela R Zimmermann, Georg Meisl, Shamasree Ghosh
Publikováno v: Journal of the American Chemical Society. 143:16621-16629
The formation of amyloid fibrils and oligomers is a hallmark of several neurodegenerative disorders, including Alzheimer's disease (AD), and contributes to the disease pathway. To progress our understanding of these diseases at a molecular level, it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e5966761c53a5224f70b34ee6cf506
https://doi.org/10.1021/jacs.1c07228
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4
Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter
Autor: Mona Seifert, Anssi M. Malinen, Eugeniu Ostrofet, Monika Spermann, Flavia S. Papini, Martin Depken, Jelmer Cnossen, Pim P. B. America, Subhas C. Bera, David Dulin, Santeri Maatsola
Publikováno v: Bera, S C, America, P P B, Maatsola, S, Seifert, M, Ostrofet, E, Cnossen, J, Spermann, M, Papini, F S, Depken, M, Malinen, A M & Dulin, D 2022, ' Quantitative parameters of bacterial RNA polymerase open-complex formation, stabilization and disruption on a consensus promoter ', Nucleic acids research, vol. 50, no. 13, pp. 7511-7528 . https://doi.org/10.1093/nar/gkac560
Nucleic acids research, 50(13), 7511-7528. Oxford University Press
Nucleic acids research, 50(13)
Transcription initiation is the first step in gene expression, and is therefore strongly regulated in all domains of life. The RNA polymerase (RNAP) first associates with the initiation factorσto form a holoenzyme, which binds, bends and opens the p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f6e38ca3ee2e0673f2e56fa20fb2a4
https://research.vu.nl/en/publications/11e1a01f-cd32-446b-ae41-073da4bd11f0
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5
Observation of two-step aggregation kinetics of amyloid
Autor: Soham, Mukhopadhyay, Subhas C, Bera, Kabir, Ramola
Publikováno v: Physical biology. 19(4)
Self-aggregation in proteins has long been studied and modeled due to its ubiquity and importance in many biological contexts. Several models propose a two step aggregation mechanism, consisting of linear growth of fibrils and secondary growth involv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f84cfa51880eb15e01cccc68f9526315
https://pubmed.ncbi.nlm.nih.gov/35381581
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6
Inhibition of sars-cov-2 polymerase by nucleotide analogs from a single-molecule perspective
Autor: Pauline van Nies, Xiangzhi Meng, Lawrence Harris, Mona Seifert, Flavia S. Papini, Hongjie Xia, Jamie J. Arnold, Ashleigh Shannon, Subhas C. Bera, Tyler L. Grove, Bruno Canard, David Dulin, Robert N. Kirchdoerfer, Steven C. Almo, Craig E. Cameron, Martin Depken, Yan Xiang, James M. Wood, Pei Yong Shi, Thi Tuyet Nhung Le
Publikováno v: eLife, 2021(10):e70968, 1-26. eLife Sciences Publications
eLife
eLife, Vol 10 (2021)
Seifert, M, Bera, S C, Van Nies, P, Kirchdoerfer, R N, Shannon, A, Le, T T N, Meng, X, Xia, H, Wood, J M, Harris, L D, Papini, F S, Arnold, J J, Almo, S, Grove, T L, Shi, P Y, Xiang, Y, Canard, B, Depken, M, Cameron, C E & Dulin, D 2021, ' Inhibition of sars-cov-2 polymerase by nucleotide analogs from a single-molecule perspective ', eLife, vol. 2021, no. 10, e70968, pp. 1-26 . https://doi.org/10.7554/eLife.70968
eLife, 10
bioRxiv
article-version (status) pre
article-version (number) 2
The absence of ‘shovel-ready’ anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8113a681cea990d5dd39b90a05094b
https://research.vu.nl/en/publications/d1a61e7d-93d0-4d77-a2d6-942d44eecad2
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8
Two step aggregation kinetics of Amyloid-β proteins from fractal analysis
Autor: Soham Mukhopadhyay, Kabir Ramola, Subhas C. Bera
Self-aggregation in proteins has long been studied and modeled due to its ubiquity and importance in many biological contexts. Several models propose a two step aggregation mechanism, consisting of linear growth of fibrils and branch formation. Singl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8caa936e3db9f2912285095269876335
https://doi.org/10.1101/2021.07.30.454448
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9
The nucleotide addition cycle of the SARS-CoV-2 polymerase
Autor: Subhas C. Bera, Flavia S. Papini, Bruno Canard, Craig E. Cameron, Mona Seifert, Jamie J. Arnold, Martin Depken, Yibulayin Wubulikasimu, Robert N. Kirchdoerfer, Salina Quack, Pauline van Nies, David Dulin
Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
Cell Reports
Cell Reports, 36(9):109650, 1-23. Cell Press
Cell Reports, 36(9)
Bera, S C, Seifert, M, Kirchdoerfer, R N, van Nies, P, Wubulikasimu, Y, Quack, S, Papini, F S, Arnold, J J, Canard, B, Cameron, C E, Depken, M & Dulin, D 2021, ' The nucleotide addition cycle of the SARS-CoV-2 polymerase ', Cell Reports, vol. 36, no. 9, 109650, pp. 1-23 . https://doi.org/10.1016/j.celrep.2021.109650
Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit (nsp12) and its intimately associated cofactors (nsp7 and nsp8). We use a hig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3651ba4759482a080f2e194a068179e5
http://resolver.tudelft.nl/uuid:443bb3b6-aeaf-4248-a5ff-549f9a61a337
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