Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Subhadip Raychaudhuri"'
Publikováno v:
Cells, Vol 2, Iss 2, Pp 361-392 (2013)
Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a central problem in the biology of apoptosis and has implications for apoptosis related disea
Externí odkaz:
https://doaj.org/article/1fbe8766b38e4f57863241cb92fb3e9b
Autor:
Subhadip Raychaudhuri
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11930 (2010)
BACKGROUND: Signaling networks are designed to sense an environmental stimulus and adapt to it. We propose and study a minimal model of signaling network that can sense and respond to external stimuli of varying strength in an adaptive manner. The st
Externí odkaz:
https://doaj.org/article/7f4a5396266c4610ab78dd2bbfd15aaf
Publikováno v:
PLoS Biology, Vol 3, Iss 10 (2005)
Externí odkaz:
https://doaj.org/article/ffa9de6e7f9d449e8dbf97330c972d55
Publikováno v:
PLoS Biology, Vol 3, Iss 6, p e160 (2005)
Development of many vertebrate tissues involves long-range cell migrations. In most cases, these migrations have been inferred from analysis of single time points and the migration process has not been directly observed and quantitated in real time.
Externí odkaz:
https://doaj.org/article/804870b1d0904a73b1323cfb91774db9
Publikováno v:
Cells
Cells, Vol 2, Iss 2, Pp 361-392 (2013)
Volume 2
Issue 2
Pages 361-392
Cells, Vol 2, Iss 2, Pp 361-392 (2013)
Volume 2
Issue 2
Pages 361-392
Apoptotic cell death is coordinated through two distinct (type 1 and type 2) intracellular signaling pathways. How the type 1/type 2 choice is made remains a central problem in the biology of apoptosis and has implications for apoptosis related disea
Autor:
Subhadip Raychaudhuri
Publikováno v:
ISRN Biomathematics. 2013:1-18
B and T lymphocytes activate the humoral and cellular arms of the adaptive immune system. The adaptive strategy works because receptors of adaptive immune cells can mount an immune response based on their affinity for antigens. Thus, affinity discrim
Autor:
Subhadip Raychaudhuri, Somkanya C. Das
Publikováno v:
Journal of Healthcare Engineering, Vol 4, Iss 1, Pp 47-66 (2013)
Biomimetic pro-apoptotic agents (e.g., BH3 mimetics) have been shown to activate the intrinsic death pathway (Type 2 apoptosis) selectively in cancer cells, a mechanism that can be key to developing successful anti-cancer therapy. This work reports m
Autor:
Subhadip Raychaudhuri
Publikováno v:
Journal of Computer Science & Systems Biology. 9
Cancer chemoresistance (including adaptive resistance) has emerged as a barrier in developing successful chemotherapeutic strategies. We use Monte Carlo simulation based single cell analysis to provide insights into the regulatory mechanisms for gene
Autor:
Subhadip Raychaudhuri, C Das Somkanya, Susan K. Pierce, Wanli Liu, Philippos K. Tsourkas, Paul Yu-Yang
Publikováno v:
Journal of Theoretical Biology. 307:174-182
B cells encounter antigen over a wide affinity range. The strength of B cell signaling in response to antigen increases with affinity, a process known as "affinity discrimination". In this work, we use a computational simulation of B cell surface dyn
Publikováno v:
Cellular & Molecular Immunology. 8:255-264
It is known from experiments that in the presence of soluble antigen, B-cell receptors (BCRs) assemble into microclusters and then collect into a macrocluster known as a ‘cap'. However, the mechanisms of BCR cluster formation during recognition of