Zobrazeno 1 - 10
of 503
pro vyhledávání: '"Subburaman Mohan"'
Publikováno v:
Biology, Vol 13, Iss 9, p 646 (2024)
Flow induced by an orbital shaker is known to produce shear stress and oscillatory flow, but the utility of this model for studying mechanical loading effects in osteoblasts is not well defined. To test this, osteoblasts derived from the long bones o
Externí odkaz:
https://doaj.org/article/54d347c48aef42c0967e803d002f63c6
Publikováno v:
Biology, Vol 13, Iss 2, p 108 (2024)
Mice lacking Claudin11 (Cldn11) manifest reduced trabecular bone mass. However, the impact of Cldn11 expression in osteoblasts in vivo remains understudied. Herein, we generated osteoblast-specific transgenic (Tg) mice expressing Cldn11 and character
Externí odkaz:
https://doaj.org/article/93a9cd80af12437fa2fa4181f4ffb7b7
Publikováno v:
Osteoporosis and Sarcopenia, Vol 8, Iss 1, Pp 1-10 (2022)
Cellular metabolism requires dissolved oxygen gas. Because evolutionary refinements have constrained mammalian dissolved oxygen levels, intracellular oxygen sensors are vital for optimizing the bioenergetic and biosynthetic use of dissolved oxygen. P
Externí odkaz:
https://doaj.org/article/bddcd68a3c2d4b20a4e28893022ebefb
Publikováno v:
Biology, Vol 12, Iss 9, p 1228 (2023)
To evaluate the relative importance of IGF-I expression in various cell types for endochondral ossification, we quantified the trabecular bone at the secondary spongiosa and epiphysis of the distal femur in 8–12-week-old male mice with a global kno
Externí odkaz:
https://doaj.org/article/feecff592f8d46cfbbe3b5c7da3c8f32
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-6 (2022)
Abstract Objectives The goal of this study was to evaluate the long-term impact of repeated (r) mild traumatic brain injury (mTBI) on the healing of fractures in a mouse model. Ten week-old male mice were subjected to r-mTBI once per day for 4 days f
Externí odkaz:
https://doaj.org/article/ce9b8ec004444e65a658ff014225e14e
Autor:
Gustavo A Gomez, Charles H Rundle, Weirong Xing, Chandrasekhar Kesavan, Sheila Pourteymoor, Robert E Lewis, David R Powell, Subburaman Mohan
Publikováno v:
eLife, Vol 11 (2022)
Pathological obesity and its complications are associated with an increased propensity for bone fractures. Humans with certain genetic polymorphisms at the kinase suppressor of ras2 (KSR2) locus develop severe early-onset obesity and type 2 diabetes.
Externí odkaz:
https://doaj.org/article/7c9a30dcd13e411aadadae3da7822fee
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
To study the role of Claudin (CLDN)12 in bone, we developed mice with a targeted deletion of exon2 in the Cldn12 gene for skeletal phenotype analysis. Micro-CT analysis of the secondary spongiosa of distal femurs of mice with targeted disruption of t
Externí odkaz:
https://doaj.org/article/cbdba399f6814996bf65cff0c5c3c037
Autor:
Bhaba K Das, Lei Wang, Toshifumi Fujiwara, Jian Zhou, Nukhet Aykin-Burns, Kimberly J Krager, Renny Lan, Samuel G Mackintosh, Ricky Edmondson, Michael L Jennings, Xiaofang Wang, Jian Q Feng, Tomasa Barrientos, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao
Publikováno v:
eLife, Vol 11 (2022)
Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation and bone-resorbing activities. Transferrin receptor 1 (Tfr1) mediates cellular iron uptake through endocytosis
Externí odkaz:
https://doaj.org/article/e7aaa3c107a7445d8a2e1c1f94e4180c
Autor:
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing
Publikováno v:
Biology, Vol 12, Iss 4, p 511 (2023)
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone. To determine how LRRK1 regulates osteoclast activity, we examined the in
Externí odkaz:
https://doaj.org/article/654079aa2f7849cbb5fe17020796f616
Publikováno v:
Life, Vol 13, Iss 4, p 878 (2023)
The anabolic effects of WNT16 on osteoblasts are well established, however, little is known regarding the role of WNT16 in chondrocytes. In this study, we evaluated Wnt16 expression and its biological effects on mouse articular chondrocytes (ACs), si
Externí odkaz:
https://doaj.org/article/0e80de92f8954b9b800d434967b085b9