Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Subbaian Brindha"'
Autor:
Rawiwan Wongnak, Subbaian Brindha, Mami Oba, Takahiro Yoshizue, Md. Din Islam, M. Monirul Islam, Hitoshi Takemae, Tetsuya Mizutani, Yutaka Kuroda
Publikováno v:
Molecules, Vol 29, Iss 11, p 2676 (2024)
The Omicron BA.5 variant of SARS-CoV-2 is known for its high transmissibility and its capacity to evade immunity provided by vaccine protection against the (original) Wuhan strain. In our prior research, we successfully produced the receptor-binding
Externí odkaz:
https://doaj.org/article/db540d4fcff048e2bb9197300c2132bb
Autor:
Rawiwan Wongnak, Subbaian Brindha, Takahiro Yoshizue, Sawaros Onchaiya, Kenji Mizutani, Yutaka Kuroda
Publikováno v:
Biophysics and Physicobiology, Vol 20 (2023)
Low-cost bacterial production of the receptor binding domain (RBD) of the SARS-CoV-2 Omicron spike protein holds significant potential in expediting the development of therapeutics against COVID-19. However, RBD contains eight cysteines forming four
Externí odkaz:
https://doaj.org/article/819f364e4fc448989118ac605516667c
Autor:
Takahiro Yoshizue, Subbaian Brindha, Rawiwan Wongnak, Hitoshi Takemae, Mami Oba, Tetsuya Mizutani, Yutaka Kuroda
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10583 (2023)
E. coli-expressed proteins could provide a rapid, cost-effective, and safe antigen for subunit vaccines, provided we can produce them in a properly folded form inducing neutralizing antibodies. Here, we use an E. coli-expressed SARS-CoV-2 receptor-bi
Externí odkaz:
https://doaj.org/article/b61963e48757446c80e24adff2a8bff3
Autor:
Md. Din Islam, Tahmina Sharmin, Imrul Hasan Tipo, Antara Saha, Sanjida Yesmin, Moushumi Ghosh Roy, Subbaian Brindha, Yutaka Kuroda, M. Monirul Islam
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2393 (2023)
The development of a dengue (DENV) vaccine remains challenging due to the heteroserotypic infection, which can result in a potentially deadly hemorrhagic fever or dengue shock syndrome, and only a tetravalent vaccine can overcome this issue. Here, we
Externí odkaz:
https://doaj.org/article/85afee49336142e982b2c7adb4f6f976
Autor:
Subbaian Brindha, Takahiro Yoshizue, Rawiwan Wongnak, Hitoshi Takemae, Mami Oba, Tetsuya Mizutani, Yutaka Kuroda
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15744 (2022)
A large-scale Escherichia coli (E. coli) production of the receptor-binding domain (RBD) of the SARS-CoV-2 could yield a versatile and low-cost antigen for a subunit vaccine. Appropriately folded antigens can potentially elicit the production of neut
Externí odkaz:
https://doaj.org/article/08ae189b284c4520923e0290d33b30fa
Autor:
Subbaian Brindha, Yutaka Kuroda
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1703 (2022)
An Escherichia coli (E. coli) production of the receptor-binding domain (RBD) of the SARS-CoV-2 (isolate Wuhan-Hu-1) spike protein would significantly accelerate the search for anti-COVID-19 therapeutics because of its versatility and low cost. Howev
Externí odkaz:
https://doaj.org/article/beae5840f29346a5a6d369340ea0dd50
Autor:
Kuroda, Takahiro Yoshizue, Subbaian Brindha, Rawiwan Wongnak, Hitoshi Takemae, Mami Oba, Tetsuya Mizutani, Yutaka
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10583
E. coli-expressed proteins could provide a rapid, cost-effective, and safe antigen for subunit vaccines, provided we can produce them in a properly folded form inducing neutralizing antibodies. Here, we use an E. coli-expressed SARS-CoV-2 receptor-bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::33dda14d46abba9a3315a8cba2833c81
Autor:
Tomonori Saotome, Sawaros Onchaiya, Subbaian Brindha, Taichi Mezaki, Satoru Unzai, Keiichi Noguchi, Jose C. Martinez, Shun‐ichi Kidokoro, Yutaka Kuroda
Publikováno v:
The FEBS Journal. 289:3205-3216
The third PDZ domain of the postsynaptic density protein 95 (PSD95-PDZ3; 11 kDa, 103 residues) has a propensity to form amyloid fibrils at high temperatures. At neutral pH, PDZ3 is natively folded, but it exhibits a peculiar three-state thermal unfol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1df6769e87f0df593aa867e72b7e838
https://doi.org/10.1111/febs.16339
https://doi.org/10.1111/febs.16339
Here we used domain 3 of dengue virus serotype 3 envelope protein (D3ED3), a natively folded globular low-immunogenicity protein, to ask whether the biophysical nature of amorphous aggregates can affect immunogenicity. We prepared amorphous oligomers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624fb77efdd012b06faab57e57a42929
https://doi.org/10.1101/2022.11.02.514810
https://doi.org/10.1101/2022.11.02.514810
Autor:
Subbaian, Brindha, Takahiro, Yoshizue, Rawiwan, Wongnak, Hitoshi, Takemae, Mami, Oba, Tetsuya, Mizutani, Yutaka, Kuroda
Publikováno v:
International journal of molecular sciences. 23(24)
A large-scale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a81ecc3efa1b8040f9043d788e90f63
https://pubmed.ncbi.nlm.nih.gov/36555383
https://pubmed.ncbi.nlm.nih.gov/36555383