Výsledky vyhledávání - "Subbaiah MAM"

Akademický článek

Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates.

Autor: Subbaiah MAM; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra Phase IV, Bangalore, PIN 560099, India. murugaiah.subbaiah123@gmail.com., Rautio J; School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Meanwell NA; The Baruch S. Blumberg Institute, Doylestown, PA 18902, USA.; Department of Medicinal Chemistry, The College of Pharmacy, The University of Michigan, Ann Arbor, MI 48109, USA.

Publikováno v: Chemical Society reviews [Chem Soc Rev] 2024 Feb 19; Vol. 53 (4), pp. 2099-2210. Date of Electronic Publication: 2024 Feb 19.

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Akademický článek

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.

Autor: He L; Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States., Zhang MY; Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States., Cox M; Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States., Zhang Q; Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States., Donnell AF; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Zhang Y; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Tarby C; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Gill P; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Subbaiah MAM; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560099, India., Ramar T; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560099, India., Reddy M; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560099, India., Puttapaka V; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560099, India., Li YX; Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States., Sivaprakasam P; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Critton D; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Mulligan D; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Xie C; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Ramakrishnan R; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Nagar J; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560099, India., Dudhgaonkar S; Biocon Bristol Myers Squibb R&D Centre, Bangalore 560099, India., Murtaza A; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Oderinde MS; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Schieven GL; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Mathur A; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Gavai AV; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Vite G; Research and Development, Bristol Myers Squibb, Princeton, New Jersey 08543, United States., Gangwar S; Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States., Poudel YB; Research and Development, Bristol Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jan 09; Vol. 15 (2), pp. 189-196. Date of Electronic Publication: 2024 Jan 09 (Print Publication: 2024).

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Akademický článek

Examining the Scope of Deriving β-Aryl Enones from Enol Silanes as Ketone Equivalents via Pd(II)-Mediated Sequential Dehydrosilylation and Arylation.

Autor: Polimera SR; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, Karnataka, India.; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, Tamil Nadu, India., Ilangovan A; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, Tamil Nadu, India., Subbaiah MAM; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, Karnataka, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2023 Jun 02; Vol. 88 (11), pp. 7256-7271. Date of Electronic Publication: 2023 May 16.

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Akademický článek

Synthetic Access to α-Oxoketene Aminals by the Nucleophilic Addition of Enol Silane-Derived Palladium(II) Enolates to Carbodiimides.

Autor: Polimera SR; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, Karnataka 560099, India.; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli, Tamil Nadu 620024, India., Ilangovan A; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli, Tamil Nadu 620024, India., Meanwell NA; Department of Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States., Subbaiah MAM; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, Karnataka 560099, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 Nov 04; Vol. 87 (21), pp. 14778-14792. Date of Electronic Publication: 2022 Oct 26.

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Akademický článek

Electrophilic Hydrazination of Cyclopropanols Using Azodicarboxylates via Copper(II) Catalysis: An Umpolung Strategy to Access β-Hydrazino Ketone Motifs.

Autor: Ramar T; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, Karnataka, India.; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, Tamil Nadu, India., Ilangovan A; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, Tamil Nadu, India., Meanwell NA; Department of Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, PO Box 4000, Princeton, New Jersey 08543-4000, United States., Subbaiah MAM; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, Karnataka, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 Nov 04; Vol. 87 (21), pp. 14596-14608. Date of Electronic Publication: 2022 Oct 03.

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Akademický článek

Orchestrating a β-Hydride Elimination Pathway in Palladium(II)-Catalyzed Arylation/Alkenylation of Cyclopropanols Using Organoboron Reagents.

Autor: Ramar T; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India.; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, India., Subbaiah MAM; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb R&D Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India., Ilangovan A; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 Apr 01; Vol. 87 (7), pp. 4508-4523. Date of Electronic Publication: 2022 Mar 15.

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Akademický článek

Bioisosteres of the Phenyl Ring: Recent Strategic Applications in Lead Optimization and Drug Design.

Autor: Subbaiah MAM; Department of Medicinal Chemistry, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, Karnataka 560099, India., Meanwell NA; Department of Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Oct 14; Vol. 64 (19), pp. 14046-14128. Date of Electronic Publication: 2021 Sep 30.

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Akademický článek

(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.

Autor: Subbaiah MAM; Department of Medicinal Chemistry (Prodrug Group), Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India. Electronic address: murugaiah.andappan@syngeneintl.com., Ramar T; Department of Medicinal Chemistry (Prodrug Group), Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Subramani L; Department of Medicinal Chemistry (Prodrug Group), Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Desai SD; Department of Biopharmaceutics, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Sinha S; Department of Pharmaceutical Candidate Optimization, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Mandlekar S; Department of Pharmaceutical Candidate Optimization, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Jenkins SM; Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States., Krystal MR; Department of Virology, Bristol Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, United States., Subramanian M; Department of Pharmaceutical Candidate Optimization, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Sridhar S; Department of Biopharmaceutics, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Padmanabhan S; Department of Pharmaceutical Candidate Optimization, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Bhutani P; Department of Pharmaceutical Candidate Optimization, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Arla R; Department of Pharmaceutical Candidate Optimization, Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore, 560099, India., Kadow JF; Department of Small Molecule Drug Discovery, Bristol Myers Squibb Research and Development, PO Box 4000, Princeton, NJ, 08543-4000, United States., Meanwell NA; Department of Small Molecule Drug Discovery, Bristol Myers Squibb Research and Development, PO Box 4000, Princeton, NJ, 08543-4000, United States.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2020 Dec 01; Vol. 207, pp. 112749. Date of Electronic Publication: 2020 Aug 21.

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Akademický článek

Utility of Organoboron Reagents in Arylation of Cyclopropanols via Chelated Pd(II) Catalysis: Chemoselective Access to β-Aryl Ketones.

Autor: Ramar T; Discovery Chemistry, BBRC, Syngene, Biocon Park, Bommasandra IV Phase, Jigani Link Road, Bangalore 560099, India.; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, India., Subbaiah MAM; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, India., Ilangovan A; Department of Chemistry, Bharathidasan University, Palkalaiperur, Thiruchirapalli 620024, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2020 Jun 19; Vol. 85 (12), pp. 7711-7727. Date of Electronic Publication: 2020 Jun 10.

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