Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections.

Autor: Amruta S Mhashilkar, Sai L Vankayala, Canhui Liu, Fiona Kearns, Priyanka Mehrotra, George Tzertzinis, Subba R Palli, H Lee Woodcock, Thomas R Unnasch

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004772 (2016)

BACKGROUND:A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeut

Externí odkaz: https://doaj.org/article/6b0f5935e3d348bea0c95f7bcb970302

RNA interference of NADPH-cytochrome P450 reductase results in reduced insecticide resistance in the bed bug, Cimex lectularius.

Autor: Fang Zhu, Sarah Sams, Tim Moural, Kenneth F Haynes, Michael F Potter, Subba R Palli

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31037 (2012)

BACKGROUND: NADPH-cytochrome P450 reductase (CPR) plays a central role in cytochrome P450 action. The genes coding for P450s are not yet fully identified in the bed bug, Cimex lectularius. Hence, we decided to clone cDNA and knockdown the expression

Externí odkaz: https://doaj.org/article/9b25eabdae544fadb5f9069fb0ad9a50

Gene content evolution in the arthropods

Autor: Gregg W. C. Thomas, Elias Dohmen, Daniel S. T. Hughes, Shwetha C. Murali, Monica Poelchau, Karl Glastad, Clare A. Anstead, Nadia A. Ayoub, Phillip Batterham, Michelle Bellair, Greta J. Binford, Hsu Chao, Yolanda H. Chen, Christopher Childers, Huyen Dinh, Harsha Vardhan Doddapaneni, Jian J. Duan, Shannon Dugan, Lauren A. Esposito, Markus Friedrich, Jessica Garb, Robin B. Gasser, Michael A. D. Goodisman, Dawn E. Gundersen-Rindal, Yi Han, Alfred M. Handler, Masatsugu Hatakeyama, Lars Hering, Wayne B. Hunter, Panagiotis Ioannidis, Joy C. Jayaseelan, Divya Kalra, Abderrahman Khila, Pasi K. Korhonen, Carol Eunmi Lee, Sandra L. Lee, Yiyuan Li, Amelia R. I. Lindsey, Georg Mayer, Alistair P. McGregor, Duane D. McKenna, Bernhard Misof, Mala Munidasa, Monica Munoz-Torres, Donna M. Muzny, Oliver Niehuis, Nkechinyere Osuji-Lacy, Subba R. Palli, Kristen A. Panfilio, Matthias Pechmann, Trent Perry, Ralph S. Peters, Helen C. Poynton, Nikola-Michael Prpic, Jiaxin Qu, Dorith Rotenberg, Coby Schal, Sean D. Schoville, Erin D. Scully, Evette Skinner, Daniel B. Sloan, Richard Stouthamer, Michael R. Strand, Nikolaus U. Szucsich, Asela Wijeratne, Neil D. Young, Eduardo E. Zattara, Joshua B. Benoit, Evgeny M. Zdobnov, Michael E. Pfrender, Kevin J. Hackett, John H. Werren, Kim C. Worley, Richard A. Gibbs, Ariel D. Chipman, Robert M. Waterhouse, Erich Bornberg-Bauer, Matthew W. Hahn, Stephen Richards

Publikováno v: Genome Biology, Vol 21, Iss 1, Pp 1-14 (2020)

Abstract Background Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive chang

Externí odkaz: https://doaj.org/article/e2b9c942e13d4b4295d07ee646e36903

Unique features of a global human ectoparasite identified through sequencing of the bed bug genome

Autor: Joshua B. Benoit, Zach N. Adelman, Klaus Reinhardt, Amanda Dolan, Monica Poelchau, Emily C. Jennings, Elise M. Szuter, Richard W. Hagan, Hemant Gujar, Jayendra Nath Shukla, Fang Zhu, M. Mohan, David R. Nelson, Andrew J. Rosendale, Christian Derst, Valentina Resnik, Sebastian Wernig, Pamela Menegazzi, Christian Wegener, Nicolai Peschel, Jacob M. Hendershot, Wolfgang Blenau, Reinhard Predel, Paul R. Johnston, Panagiotis Ioannidis, Robert M. Waterhouse, Ralf Nauen, Corinna Schorn, Mark-Christoph Ott, Frank Maiwald, J. Spencer Johnston, Ameya D. Gondhalekar, Michael E. Scharf, Brittany F. Peterson, Kapil R. Raje, Benjamin A. Hottel, David Armisén, Antonin Jean Johan Crumière, Peter Nagui Refki, Maria Emilia Santos, Essia Sghaier, Sèverine Viala, Abderrahman Khila, Seung-Joon Ahn, Christopher Childers, Chien-Yueh Lee, Han Lin, Daniel S. T. Hughes, Elizabeth J. Duncan, Shwetha C. Murali, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, Harshavardhan Doddapaneni, Kim C. Worley, Donna M. Muzny, David Wheeler, Kristen A. Panfilio, Iris M. Vargas Jentzsch, Edward L. Vargo, Warren Booth, Markus Friedrich, Matthew T. Weirauch, Michelle A. E. Anderson, Jeffery W. Jones, Omprakash Mittapalli, Chaoyang Zhao, Jing-Jiang Zhou, Jay D. Evans, Geoffrey M. Attardo, Hugh M. Robertson, Evgeny M. Zdobnov, Jose M. C. Ribeiro, Richard A. Gibbs, John H. Werren, Subba R. Palli, Coby Schal, Stephen Richards

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

The bed bug, Cimex lectularius, is a ubiquitous human ectoparasite with global distribution. Here, the authors sequence the genome of the bed bug and identify reductions in chemosensory genes, expansion of genes associated with blood digestion and ge

Externí odkaz: https://doaj.org/article/1ddff0b328da4a45acaa2a66265f06db

Mapping distributions of the Lyme disease vector, Ixodes scapularis, and spirochete, Borrelia burgdorferi, in Kentucky using passive and active surveillance

Autor: Anna R, Pasternak, Subba R, Palli

Publikováno v: Ticks and Tick-borne Diseases. 13:101885

Lyme disease is the most common tick-borne illness in the United States and is becoming more prevalent each year. It is transmitted to humans and animals through the bites of Ixodes scapularis ticks infected with Borrelia burgdorferi in the eastern U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c54d98a8fbbb0ed9cf1a17db7077531
https://doi.org/10.1016/j.ttbdis.2021.101885