Výsledky vyhledávání - "Subashini R. Iyer"

Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting

Autor: Anthony Warrington, Debra Ann Fadool, Subashini R. Iyer, Patricio Velez, Austin B. Schwartz

Voltage-dependent potassium channels (Kv) go beyond the stabilization of the resting potential and regulate biochemical pathways, regulate intracellular signaling, and detect energy homeostasis. Because targeted deletion and pharmacological block of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2b7c5c5a9fde88fbb2c24b262b144b
https://europepmc.org/articles/PMC4982906/

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Development of a nonintegrating Rev-dependent lentiviral vector carrying diphtheria toxin A chain and human TRAF6 to target HIV reservoirs

Autor: Barney Bishop, Subashini R. Iyer, Zhongwei Tang, Dongyang Yu, Yanfang Zheng, Yuntao Wu, Mark Spear, Zhirui Wang

Publikováno v: Gene therapy

Persistence of human immunodeficiency virus (HIV) despite highly active antiretroviral therapy (HAART) is a lasting challenge to virus eradication. To develop a strategy complementary to HAART, we constructed a series of Rev-dependent lentiviral vect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d06002fc87a66fe23e07266f03bd23a
https://doi.org/10.1038/gt.2010.53

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Measurement of Human Immunodeficiency Virus Type 1 Preintegration Transcription by Using Rev-Dependent Rev-CEM Cells Reveals a Sizable Transcribing DNA Population Comparable to That from Proviral Templates

Autor: Yuntao Wu, Subashini R. Iyer, Dongyang Yu, Leonid Margolis, Angelique Biancotto

Publikováno v: Journal of Virology. 83:8662-8673

Preintegration transcription is an early process in human immunodeficiency virus type 1 infection and has been suggested to occur at a low level. The templates have also been suggested to represent a small population of nonintegrated viral DNA, parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5488538e9718b08cb3b280c8ad9ad7c6
https://doi.org/10.1128/jvi.00874-09

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HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells

Autor: Xuehua Xu, Juan Liu, Dongyang Yu, Alyson Yoder, James N. Cooper, Jeremy Kelly, Liane Agulto, Paul J. Vorster, David A. Stephany, Li Dong, Subashini R. Iyer, Yuntao Wu, Weifeng Wang, Jon W. Marsh

Publikováno v: Cell. 134(5):782-792

SummaryBinding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and signal transduction. The fusion process has been well characterized, yet the role of coreceptor signaling remains elusive. Here, we describe a critical funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb6c1f293eae8f64a0ea35cf1f11463

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Human macrophages support persistent transcription from unintegrated HIV-1 DNA

Autor: Margaret H. Beddall, Yuntao Wu, Jon W. Marsh, Jeremy Kelly, Subashini R. Iyer, Dongyang Yu

Publikováno v: Virology. 372(2):300-312

Retroviruses require integration of their RNA genomes for both stability and productive viral replication. In HIV infection of non-dividing, resting CD4 T cells, where integration is greatly impeded, the reverse transcribed HIV DNA has limited biolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54fc8bc4eb5774c4254320a7e769f90

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