Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Subashini Karunakaran"'
Autor:
Paul Petrus, Tara L. Fernandez, Michelle M. Kwon, Jenny L. Huang, Victor Lei, Nooshin Seyed Safikhan, Subashini Karunakaran, Daniel J. O'Shannessy, Xiaowei Zheng, Sergiu-Bogdan Catrina, Earl Albone, Jukka Laine, Kirsi Virtanen, Susanne M. Clee, Timothy J. Kieffer, Christophe Noll, André C. Carpentier, James D. Johnson, Mikael Rydén, Edward M. Conway
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 489-501 (2019)
Background: A positive energy balance promotes white adipose tissue (WAT) expansion which is characterized by activation of a repertoire of events including hypoxia, inflammation and extracellular matrix remodelling. The transmembrane glycoprotein CD
Externí odkaz:
https://doaj.org/article/91172f5eb18d4a02a74e3a099126ede6
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88352 (2014)
These data suggest that insulin secretion in WSB mice is blunted specifically in vivo, either due to a reduced insulin requirement and/or due to factors that are absent or destroyed in vitro. These studies also highlight the role of post-natal growth
Externí odkaz:
https://doaj.org/article/4efb163c373146b5be049c08bcf9bf2b
Autor:
Su-Jin Kim, Cuilan Nian, Subashini Karunakaran, Susanne M Clee, Carlos M Isales, Christopher H S McIntosh
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40156 (2012)
Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that potentiates glucose-stimulated insulin secretion during a meal. Since GIP has also been shown to exert β-cell prosurvival and adipocyte lipogenic effects in rodent
Externí odkaz:
https://doaj.org/article/d81c14c65d904b4e959668416981da14
Autor:
Connie L. K. Leung, Subashini Karunakaran, Michael G. Atser, Leyla Innala, Xiaoke Hu, Victor Viau, James D. Johnson, Susanne M. Clee
Publikováno v:
Physiological Genomics. 55:132-146
Genetic factors affect an individual’s risk of developing obesity, but in most cases each genetic variant has a small effect. Discovery of genes that regulate obesity may provide clues about its underlying biological processes and point to new ways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9fc5d792236603b3521659c4837c7b
https://doi.org/10.1152/physiolgenomics.00137.2022
https://doi.org/10.1152/physiolgenomics.00137.2022
Autor:
Leung, Connie L. K., Subashini Karunakaran, Atser, Michael G., Innala, Leyla, Xiaoke Hu, Viau, Victor, Johnson, James D., Clee, Susanne M.
Publikováno v:
Physiological Genomics; Mar2023, Vol. 55 Issue 3, p132-146, 15p
Autor:
James D. Johnson, Nooshin Safikhan, Xiaowei Zheng, Jukka Laine, Mikael Rydén, Earl Albone, Christophe Noll, André C. Carpentier, Subashini Karunakaran, Timothy J. Kieffer, Michelle M. Kwon, Susanne M. Clee, Sergiu-Bogdan Catrina, Kirsi A. Virtanen, Jenny Li-Ying Huang, Tara L. Fernandez, Daniel J. O'Shannessy, Victor Lei, Edward M. Conway, Paul Petrus
Publikováno v:
EBioMedicine. 44:489-501
Background A positive energy balance promotes white adipose tissue (WAT) expansion which is characterized by activation of a repertoire of events including hypoxia, inflammation and extracellular matrix remodelling. The transmembrane glycoprotein CD2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bf8cdbbea0f4eb2bd5b1149b7d0b7d
https://doi.org/10.1016/j.ebiom.2019.05.057
https://doi.org/10.1016/j.ebiom.2019.05.057
Autor:
Travis D. Webber, Susanne M. Clee, Robert K. Baker, Cara E. Ellis, Majid Mojibian, Timothy J. Kieffer, Scott D. Covey, Shannon O'Dwyer, Victor So, Ji Soo Yoon, Sandra Pereira, Subashini Karunakaran, Maria M. Glavas
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
The relative contribution of peripheral and central leptin signalling to the regulation of metabolism and the mechanisms through which leptin affects glucose homeostasis have not been fully elucidated. We generated complementary lines of mice with ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4cb60123d29816776e2d5b3b70c6f0
http://link.springer.com/article/10.1038/s41598-019-39498-3
http://link.springer.com/article/10.1038/s41598-019-39498-3
Autor:
Susanne M. Clee, Subashini Karunakaran
Publikováno v:
Physiological Genomics. 50:35-51
The metabolic syndrome (MetS) is a complex constellation of metabolic abnormalities including obesity, abnormal glucose metabolism, dyslipidemia, and elevated blood pressure that together substantially increase risk for cardiovascular disease and Typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc96c0d448f580d423d5b1c8236bb584
https://doi.org/10.1152/physiolgenomics.00059.2017
https://doi.org/10.1152/physiolgenomics.00059.2017
Publikováno v:
Physiological Genomics. 45:F191-F199
The rising prevalence of obesity is one of the greatest health challenges facing the world today. Discovery of genetic factors affecting obesity risk will provide important insight to its etiology that could suggest new therapeutic approaches. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba180ab4e6a3204ea3082048577f2c3
https://doi.org/10.1152/physiolgenomics.00159.2012
https://doi.org/10.1152/physiolgenomics.00159.2012
Autor:
Subashini Karunakaran, Haiyan Zou, Shuai Liu, Anthony G. Phillips, Stephanie L. Borgland, Benjamin Boutrel, Carine Dias, Jovi C Y Wong, Gwenaël Labouèbe, Susanne M. Clee
Publikováno v:
Nature neuroscience
Nature Neuroscience, vol. 16, no. 3, pp. 300-308
Nature Neuroscience, vol. 16, no. 3, pp. 300-308
The prevalence of obesity has drastically increased over the last few decades. Exploration into how hunger and satiety signals influence the reward system can help us to understand non-homeostatic mechanisms of feeding. Evidence suggests that insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e858e6f14a6dd1b3ec6ec5bd7c42b9af
http://europepmc.org/articles/PMC4072656
http://europepmc.org/articles/PMC4072656