Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Subash Velaparthi"'
Autor:
Mariangela Urbano, Olivier Civelli, Subash Velaparthi, Hugh Rosen, Marie-Therese Schaeffer, Steven D. Brown, Zhiwei Wang, Peter Hodder, Miguel Guerrero, Edward Roberts, S. Adrian Saldanha, Peter Chase, Jian Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7135-7141
Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3(2H)-one as a NPBWR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef79ca019a4a4668683808e2cd7efee3
https://doi.org/10.1016/j.bmcl.2012.09.074
https://doi.org/10.1016/j.bmcl.2012.09.074
Publikováno v:
Journal of the American Chemical Society. 134:14670-14673
A highly efficient and stereoselective arylation of in situ-generated azavinyl carbenes affording 2,2-diaryl enamines at ambient temperatures has been developed. These transition-metal carbenes are directly produced from readily available and stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41991a9c8437ec1b384a58bed3ae4b9
https://doi.org/10.1021/ja3062453
https://doi.org/10.1021/ja3062453
Autor:
Jian Zhao, Mariangela Urbano, Miguel Guerrero, Hugh Rosen, Subash Velaparthi, Edward Roberts, Marie-Therese Schaeffer, Steven J. Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5470-5474
Recent evidence suggests an innovative application of chemical modulators targeting the S1P4 receptor as novel mechanism-based drugs for the treatment of influenza virus infection. Modulation of the S1P4 receptor may also represent an alternative the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5f83e05ec04a5d2050b04bf69a18fa
https://doi.org/10.1016/j.bmcl.2011.06.132
https://doi.org/10.1016/j.bmcl.2011.06.132
Autor:
Denise L. Holzle, Pavel A. Petukhov, Subash Velaparthi, Bai He, Chris Pennington, Richard B. van Breemen, Aruna Mahesh, Sylvie Y. Blond, Michael Brunsteiner, Gilles Pieffet
Publikováno v:
Journal of Medicinal Chemistry. 52:7003-7013
A binding ensemble profiling with (f)photoaffinity labeling (BEProFL) approach that utilizes photolabeling of HDAC8 with a probe containing a UV-activated aromatic azide, mapping of the covalent modifications by liquid chromatography-tandem mass spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02204d7e13dd2a07ea7ab49d96ebd1a0
https://doi.org/10.1021/jm9005077
https://doi.org/10.1021/jm9005077
Publikováno v:
ChemInform. 44
A stereoselective arylation of triazole substrates with concomitant loss of N2 is developed to yield 2,2-diaryl enamines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf1e9ca33bf7e20b968269d7c90eb0f
https://doi.org/10.1002/chin.201309069
https://doi.org/10.1002/chin.201309069
Autor:
Samit Kumar Dutta, K. Narsimulu, Gonuguntla Anjaiah, Shaik Jeelani Basha, Ajit C. Kunwar, Gangavaram V. M. Sharma, Srinivas Reddy Kodeti, Subash Velaparthi
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 18(50)
This study describes chirality- or template-mediated helical induction in achiral β-peptides for the first time. A strategy of end capping β-peptides derived from β-hGly (the smallest achiral β-amino acid) with a chiral β-amino acid that possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32acb9903c0b97ea781194b3ab26c0bd
https://pubmed.ncbi.nlm.nih.gov/23111903
https://pubmed.ncbi.nlm.nih.gov/23111903
Autor:
Mariangela Urbano, Miguel Guerrero, Marie-Therese Schaeffer, Steven J. Brown, Hugh Rosen, Subash Velaparthi, Edward Roberts, Jian Zhao
Publikováno v:
ChemInform. 43
CYM 50333 (I) and CYM 50367 (II), novel selective S1P4 antagonists with activities in the nanomolar range, represent valuable small molecule tools to investigate the biological and pharmacological role of the target receptor in megakaryocyte differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d45ae913df2ba0fe6816228c213351c5
https://doi.org/10.1002/chin.201203198
https://doi.org/10.1002/chin.201203198
Autor:
Melissa Crisp, Hugh Rosen, Subash Velaparthi, Mariangela Urbano, Peter Hodder, Steven D. Brown, Miguel Guerrero, Edward Roberts, Peter Chase, Marie-Therese Schaeffer
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(22)
High affinity and selective S1P(4) receptor (S1P(4)-R) small molecule agonists may be important proof-of-principle tools used to clarify the receptor biological function and effects to assess the therapeutic potential of the S1P(4)-R in diverse disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7dacefc71ea9b18a07ffbc5f3cf68ca
https://pubmed.ncbi.nlm.nih.gov/21982495
https://pubmed.ncbi.nlm.nih.gov/21982495
Autor:
Mariangela, Urbano, Miguel, Guerrero, Jian, Zhao, Subash, Velaparthi, Marie-Therese, Schaeffer, Steven, Brown, Hugh, Rosen, Edward, Roberts
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Recent evidence suggests an innovative application of chemical modulators targeting the S1P(4) receptor as novel mechanism-based drugs for the treatment of influenza virus infection. Modulation of the S1P(4) receptor may also represent an alternative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8806484267285e99f130daa35b09d145
https://pubmed.ncbi.nlm.nih.gov/21783362
https://pubmed.ncbi.nlm.nih.gov/21783362
Autor:
Denise L. Holzle, Pavel A. Petukhov, He Bai, Subash Velaparthi, Michael Brunsteiner, Sylvie Y. Blond, Raghupathi Neelarapu
Publikováno v:
Journal of medicinal chemistry. 54(13)
The design, synthesis, docking, and biological evaluation of novel potent HDAC3 and HDAC8 isoxazole- and pyrazole-based diazide probes suitable for binding ensemble profiling with photoaffinity labeling (BEProFL) experiments in cells is described. Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c8398e80d5080bf2c1d0ea5938fd58
https://pubmed.ncbi.nlm.nih.gov/21548582
https://pubmed.ncbi.nlm.nih.gov/21548582