Výsledky vyhledávání - "Subash Krishnan"

Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies

Autor: Julia Hoeng, Arkadiusz K. Kuczaj, Patrick Vanscheeuwijck, Subash Krishnan, Falk Radtke, Wei Teck Tan, Tom Lee, Francesco Lucci, Sandra Schorderet Weber, Didier Goedertier

Publikováno v: Journal of Visualized Experiments.

The capillary aerosol generator (CAG) is operated with the principal of thermal liquid evaporation through heating of e-liquid in the initial phase, followed by nucleation and condensation regulated through a mixture of airflow to generate aerosols,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc026716c884fcea5c645b747f2fd78
https://doi.org/10.3791/61021-v

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Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

Autor: Karsta Luettich, Patrick Vanscheeuwijck, Demetrius Yeo, Gregory Vuillaume, Wei Ting Lim, Ansgar Büttner, Patrice Leroy, Subash Krishnan, Stéphanie Boué, Julia Hoeng, Ee Tsin Wong, Manuel C. Peitsch, Sin Kei Wong

Publikováno v: Toxicological Sciences

We conducted an inhalation study, in accordance with Organisation for Economic Co-operation and Development Test Guideline 453, exposing A/J mice to tobacco heating system (THS) 2.2 aerosol or 3R4F reference cigarette smoke (CS) for up to 18 months t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d54343f1a6382b0ae38293c9c3a2ae5
https://doi.org/10.1093/toxsci/kfaa131

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Experimental and computational investigation of a nose-only exposure chamber

Autor: Patrick Vanscheeuwijck, Subash Krishnan, Julia Hoeng, Wei Teck Tan, Francesco Lucci, Arkadiusz K. Kuczaj, Rudolph Jaeger

Publikováno v: Aerosol Science and Technology, 54(3), 277-290. Taylor & Francis

Inhalation exposure chambers may be used for in vivo drug delivery or toxicological assessments among other applications. Nose-only exposure chamber (NOEC) systems limit non-respiratory aerosol exposure pathways that may affect biological response an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35f0cf874637de87f01787b13d618c4
http://www.scopus.com/inward/record.url?scp=85075366486&partnerID=8YFLogxK

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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology

Autor: Gregory Vuillaume, Blaine Phillips, Julia Hoeng, Emilija Veljkovic, Ulrike Kogel, Celine Merg, Davide Sciuscio, Subash Krishnan, Patrick Vanscheeuwijck, Tom Lee, Nikolai V. Ivanov, Florian Martin, Patrice Leroy, Bjoern Titz, Ashraf Elamin, Walter K. Schlage, Manuel C. Peitsch

Publikováno v: Food and Chemical Toxicology. 116:388-413

Within the framework of a systems toxicology approach, the inhalation toxicity of aerosol from a novel tobacco-heating potentially modified risk tobacco product (MRTP), the carbon-heated tobacco product (CHTP) 1.2, was characterized and compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bdd935ef74f8858f6145a92c98f6ef
https://doi.org/10.1016/j.fct.2018.04.015

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Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague–Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology

Autor: Gregory Vuillaume, Manuel C. Peitsch, Patrick Vanscheeuwijck, Anita R. Iskandar, Monali Bera, Emilija Veljkovic, Jan Verbeeck, Subash Krishnan, Blaine Phillips, Stéphanie Boué, Walter K. Schlage, Patrice Leroy, Aneli Utan, Julia Hoeng, Ulrike Kogel, Marco Esposito

Publikováno v: Inhalation Toxicology. 27:405-431

Toxicity of nebulized nicotine (Nic) and nicotine/pyruvic acid mixtures (Nic/Pyr) was characterized in a 28-day Organization for Economic Co-operation and Development 412 inhalation study with additional transcriptomic and lipidomic analyses. Sprague

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e711c5d14f915386a706c74a3b0ba62
https://doi.org/10.3109/08958378.2015.1046000

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Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 109(Pt 1)

While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in separate studies, limited data on the inhalation toxicity of them is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22c115fe6b6de31d83701cb09b475de
https://pubmed.ncbi.nlm.nih.gov/28882640

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Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice

Publikováno v: Scientific Data

Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of an aerosol derived from a pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b99506fdf85625b37e328993853f23b
https://doi.org/10.1038/sdata.2015.77

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