Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Subarno Paul"'
Autor:
Shailendra Singh, Subarno Paul, Chandrabose Karthikeyan, Natércia F. Brás, Chanakya Nath Kundu, Narayana Subbiah Hari Narayana Moorthy
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 117 (2022)
FASN is a metabolic oncoprotein that is overexpressed in multiple cancers and regulates the fatty acid requirements of proliferating cells. Thus, FASN has been proposed as a promising target for anticancer drug discovery. Herein, we report the de nov
Externí odkaz:
https://doaj.org/article/6e39b6da76b54549aebde68ab53dde58
Autor:
Somya Ranjan Dash, Biswajit Das, Chinmay Das, Saptarshi Sinha, Subarno Paul, Rajalaxmi Pradhan, Chanakya Nath Kundu
Publikováno v:
Nanomedicine. 18:19-33
Aim: This study aimed to explore the antiangiogenic mechanism of quinacrine-gold hybrid nanoparticle (QAuNP) and near-infrared (NIR) radiation in patient-derived primary breast cancer stem cells. Materials & methods: Various cell-based in ovo angioge
Autor:
Biswajit Das, Chinmayee Sethy, Subhajit Chatterjee, Somya Ranjan Dash, Saptarshi Sinha, Subarno Paul, Kunal Goutam, Chanakya Nath Kundu
Publikováno v:
Journal of Cell Communication and Signaling.
A trans-membrane receptor, mesenchymal-epithelial transition factor (cMET), is responsible for cancer metastasis and angiogenesis. A very little is known about the role of cMET in cancer stem cells (CSCs). Quinacrine (QC), a bioactive agent, has show
Publikováno v:
Journal of Cell Communication and Signaling.
Cancer stem cells (CSCs) cause drug resistance in cancer due to its extensive drug efflux, DNA repair and self-renewal capability. ATP binding cassette subfamily G member 2 (ABCG2) efflux pump afford protection to CSCs in tumors, shielding them from
Publikováno v:
Pharmacological research. 184
Cancer stem cells (CSCs) constitute a small population of cancer cells in the tumor microenvironment (TME), which are responsible for metastasis, angiogenesis, drug resistance, and cancer relapse. Understanding the key signatures and resistance mecha
Autor:
Saptarshi Sinha, Subhajit Chatterjee, Subarno Paul, Biswajit Das, Somya Ranjan Dash, Chinmay Das, Chanakya Nath Kundu
Publikováno v:
Experimental cell research. 420(1)
Although sensitization of BRCA-mutated, homologous recombination (HR)-deficient breast cancer cells through PARP inhibitor is widely studied, not much is known about the treatment of BRCA-wild-type, HR-proficient breast cancer. Here, we aim to invest
Autor:
Rajalaxmi Pradhan, Subarno Paul, Biswajit Das, Saptarshi Sinha, Somya Ranjan Dash, Mahitosh Mandal, Chanakya Nath Kundu
Publikováno v:
The Journal of Nutritional Biochemistry. 113:109257
Cancer associated fibroblasts (CAFs) are one of the highly abundant components in the tumor microenvironment (TME). They secrete several cytokines, which amplified tumor progression, invasion, stemness, metastasis and angiogenesis. Here, we evaluate
Autor:
Subhajit Chatterjee, Ajit Kumar Dhal, Subarno Paul, Saptarshi Sinha, Biswajit Das, Somya Ranjan Dash, Chanakya Nath Kundu
Publikováno v:
Journal of cancer research and clinical oncology. 148(12)
Inhibition of Poly (ADP-ribose) Polymerases (PARP) results in the blocking of DNA repair cascades that eventually leads to apoptosis and cancer cell death. PARP inhibitors (PARPi) exhibit their actions either by inhibiting PARP-induced PARylation and
Autor:
Biswajit Das, Preeti Grewal, Shailendra Sisodiya, Subarno Paul, Deepika Nayak, Uttam Chand Banerjee, Hiteshkumar Chaudhary, Divine P Daniel, Sankar K. Guchhait, Gulshan Kumar, Chanakya Nath Kundu
Publikováno v:
Bioorganicmedicinal chemistry letters. 49
Two series of (hetero)arylamino-naphthoquinones and benzo-fused carbazolequinones were considered for study with the rationale that related structural motifs are present in numerous drugs, clinical trial agents, natural products and hTopoIIα inhibit
Autor:
Chinmayee Sethy, Rajalaxmi Pradhan, Subhajit Chatterjee, Saptarshi Sinha, Chanakya Nath Kundu, Subarno Paul, Somya Ranjan Dash, Jasaswini Tripathy, Biswajit Das, Rupayana Panda
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 40:102502
Cancer stem cells (CSCs) are the tumor cell subpopulations that can self-renew, differentiate, initiate and maintain tumor growth. CSCs are frequently drug-resistant, resulting in tumor recurrence, metastasis, and angiogenesis. Herein, using in vitro