Výsledky vyhledávání - "Sub Onderwijsinstituut Farmacie"

The 5HTOL/5HIAA Ratio as a Biomarker of Alcohol Hangover

Autor: Mackus, Marlou, van de Loo, Aurora J A E, van den Bogaard, Willie J M, Korte-Bouws, Gerdien A H, Garssen, Johan, Verster, Joris C, Afd Pharmacology, dIRAS RA-1, Sub Onderwijsinstituut Farmacie, Pharmacology

Publikováno v: Journal of Clinical Medicine, 10(18), 1. MDPI AG
Journal of Clinical Medicine, Vol 10, Iss 4241, p 4241 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 10; Issue 18; Pages: 4241

Assessment of the presence and severity of alcohol hangovers relies on the subjective method of self-report. Therefore, there is a need of adequate biomarkers that (1) correlate significantly with hangover severity, and (2) correspond to the level of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654a26225fdf3bb0b104496119adfaab
https://dspace.library.uu.nl/handle/1874/419709

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The 5-HT1A/1B-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and 'waiting' impulsivity, but increases 'stopping' impulsivity

Autor: Korte, S Mechiel, Prins, Jolanda, Van den Bergh, Filip S, Oosting, Ronald S, Dupree, Rudy, Korte-Bouws, Gerdien A H, Westphal, Koen G C, Olivier, Berend, Denys, Damiaan A, Garland, Alexis, Güntürkün, Onur, Pharmacology, Afd Pharmacology, Sub Onderwijsinstituut Farmacie

Publikováno v: European Journal of Pharmacology, 794, 257. Elsevier
European Journal of Pharmacology, 794, 257-269. ELSEVIER SCIENCE BV
European journal of pharmacology, 794, 257-269. Elsevier

The 5-HT1A/1B-receptor agonist eltoprazine has a behavioral drug signature that resembles that of a variety of psychostimulant drugs, despite the differences in receptor binding profile. These psychostimulants are effective in treating impulsivity di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb905d5cdfc9cb517543d850a45ef5ca
https://doi.org/10.1016/j.ejphar.2016.11.024

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Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping

Autor: Jordan, Nan Yeun, Mimpen, Jolet Y., van den Bogaard, Willie J. M., Flesch, Frits M., van de Meent, Michiel H. M., Torano, Javier Sastre, Sub Biomolecular analysis, Sub Onderwijsinstituut Farmacie, Medicinal Chemistry and Chemical Biology

Publikováno v: Journal of chromatography. B, 995, 70. Elsevier

Cytochrome P450 1A2 (CYP1A2) plays an important role in drug metabolism. Caffeine (CAF) is converted into paraxanthine (PX) by this enzyme and is used as a xenobiotic substrate to determine the CYP1A2 phenotype in humans. A method for the quantificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aca35aaeebd6709ce9dfcc874fe4310
https://pubmed.ncbi.nlm.nih.gov/26038236

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The many different faces of major depression: it is time for personalized medicine

Autor: Korte, S Mechiel, Prins, Jolanda, Krajnc, Anne M, Hendriksen, Hendrikus, Oosting, Ronald S, Westphal, Koen G, Korte-Bouws, Gerdien A H, Olivier, Berend, Pharmacology, Sub BasicPharmacology&Psychopharmacology, Sub General Pharmacology, Sub Immunopharmacology, Sub Onderwijsinstituut Farmacie

Publikováno v: European Journal of Pharmacology, 753, 88. Elsevier

First line antidepressants are the so-called SSRIs (selective serotonin reuptake inhibitors), e.g. fluvoxamine, fluoxetine, sertraline, paroxetine and escitalopram. Unfortunately, these drugs mostly do not provide full symptom relief and have a slow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73b93324a6e51e4460036af86464c7e
https://doi.org/10.1016/j.ejphar.2014.11.045

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