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Akademický článek

Potent Antimicrobial Azoles: Synthesis, In Vitro and In Silico Study

Autor: Zeynep Özdemir, Yaren Nur Zenni, Arzu Karakurt, Suat Sari, Selma Saraç, Mevlüt Akdağ, İrem Bozbey Merde, Didem Kart, Roberto Venanzoni, Giancarlo Angeles Flores, Paola Angelini, Muzammil Kabier, Bijo Mathew, Simone Carradori

Publikováno v: Antibiotics, Vol 13, Iss 11, p 1044 (2024)

Background/Objectives: The increase in fungal infections, both systemic and invasive, is a major source of morbidity and mortality, particularly among immunocompromised people such as cancer patients and organ transplant recipients. Because of their

Externí odkaz: https://doaj.org/article/d4aea20ccdaa4573a1222f4a09bac6ad

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Akademický článek

Advances in the natural α‐glucosidase inhibitors

Autor: Didem Şöhretoğlu, Gülin Renda, Randolph Arroo, Jianbo Xiao, Suat Sari

Publikováno v: eFood, Vol 4, Iss 5, Pp n/a-n/a (2023)

Abstract α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin leve

Externí odkaz: https://doaj.org/article/09d1faea199f43b2add03955f98e1235

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Akademický článek

Flavonoids as tyrosinase inhibitors in in silico and in vitro models: basic framework of SAR using a statistical modelling approach

Autor: Katarzyna Jakimiuk, Suat Sari, Robert Milewski, Claudiu T. Supuran, Didem Şöhretoğlu, Michał Tomczyk

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 427-436 (2022)

Flavonoids are widely distributed in plants and constitute the most common polyphenolic phytoconstituents in the human diet. In this study, the in vitro inhibitory activity of 44 different flavonoids (1–44) against mushroom tyrosinase was studied,

Externí odkaz: https://doaj.org/article/49f0bba030924193a71ddae437471e85

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Akademický článek

Rational Design of New Monoterpene-Containing Azoles and Their Antifungal Activity

Autor: Nikolai S. Li-Zhulanov, Nadezhda P. Zaikova, Suat Sari, Dolunay Gülmez, Suna Sabuncuoğlu, Keriman Ozadali-Sari, Sevtap Arikan-Akdagli, Andrey A. Nefedov, Tatyana V. Rybalova, Konstantin P. Volcho, Nariman F. Salakhutdinov

Publikováno v: Antibiotics, Vol 12, Iss 5, p 818 (2023)

Azole antifungals, including fluconazole, have long been the first-line antifungal agents in the fight against fungal infections. The emergence of drug-resistant strains and the associated increase in mortality from systemic mycoses has prompted the

Externí odkaz: https://doaj.org/article/213ab024b8e348f0b979f76e52e7d28d

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Akademický článek

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells

Autor: Idowu Fadayomi, Suat Sari, Mark Kitchen, Jóhannes Reynisson, Nicholas Forsyth, Wen-Wu Li

Publikováno v: Pharmacological Research - Modern Chinese Medicine, Vol 3, Iss , Pp 100074- (2022)

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat

Externí odkaz: https://doaj.org/article/d4dac6fc44a64e7c8c08745ef868e96d

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Akademický článek

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents

Autor: Ayesha Zafar, Suat Sari, Euphemia Leung, Lisa I. Pilkington, Michelle van Rensburg, David Barker, Jóhannes Reynisson

Publikováno v: Molecules, Vol 22, Iss 12, p 2254 (2017)

A panel of docking scaffolds was developed for the known molecular targets of the anticancer agents, thieno[2,3-b]pyridines, in order to glean insight into their mechanism of action. The reported targets are the copper-trafficking antioxidant 1 prote

Externí odkaz: https://doaj.org/article/b6244b2a3b8346fe9400ba4d4bcff4b7

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