Comprehensive Interactome Analysis for the Sole Adenylyl Cyclase Cyr1 of Candida albicans

Autor: Guisheng Zeng, Suat Peng Neo, Li Mei Pang, Jiaxin Gao, Shu Chen Chong, Jayantha Gunaratne, Yue Wang

Publikováno v: Microbiology Spectrum, Vol 10, Iss 6 (2022)

ABSTRACT Cyr1, the sole adenylyl cyclase of the fungal pathogen Candida albicans, is a central component of the cAMP/protein kinase A signaling pathway that controls the yeast-to-hypha transition. Cyr1 is a multivalent sensor and integrator of variou

Externí odkaz: https://doaj.org/article/51e168d903224b5a91d79f61e1058418

Englerin A Rewires Phosphosignaling via Hsp27 Hyperphosphorylation to Induce Cytotoxicity in Renal Cancer Cells

Autor: Suat Peng Neo, Asfa Alli-Shaik, Sheena Wee, Zijie Lim, Jayantha Gunaratne

Publikováno v: Journal of Proteome Research. 21:1948-1960

Englerin A (EA) is a small-molecule natural product with selective cytotoxicity against renal cancer cells. EA has been shown to induce apoptosis and cell death through cell-cycle arrest and/or insulin signaling pathways. However, its biological mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cb36519926a4951fec958d1e10c564
https://doi.org/10.1021/acs.jproteome.2c00248

Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions

Autor: Paul Atherton, Rafaella Konstantinou, Suat Peng Neo, Emily Wang, Eleonora Balloi, Marina Ptushkina, Hayley Bennett, Kath Clark, Jayantha Gunaratne, David Critchley, Igor Barsukov, Edward Manser, Christoph Ballestrem

Publikováno v: Atherton, P, Konstantinou, R, Neo, S P, Wang, E, Balloi, E, Ptushkina, M, Bennett, H, Clark, K, Gunaratne, J, Critchley, D, Barsukov, I, Manser, E & Ballestrem, C 2022, ' Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions ', Journal of Cell Biology, vol. 221, no. 10, e202107022 . https://doi.org/10.1083/jcb.202107022

The formation of healthy tissue involves continuous remodeling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ad7fc8074066f48967fc1a884157d3
https://doi.org/10.1083/jcb.202107022

Epithelial protein lost in neoplasm (EPLIN)-β is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration

Autor: Dan Li, Suat Peng Neo, Jayantha Gunaratne, Kanaga Sabapathy

Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::345bdc0bd5fe42b8b7ea6a9cf1a44d27
https://doi.org/10.1101/2022.06.16.496394

Tensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions

Autor: Igor L. Barsukov, Eleonora Balloi, David R. Critchley, Rafaella Konstantinou, Suat Peng Neo, Emily C.S. Wang, Hayley M. Bennett, Kath Clark, Jayantha Gunaratne, Paul Atherton, Marina Ptushkina, Edward Manser, Christoph Ballestrem

The formation of healthy tissue involves continuous remodelling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6df1a0020b30dad9f45e4f7f3e32c35
https://doi.org/10.1101/2021.07.16.452612