Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition

Autor: John Colleran, Nicoló Zuin Fantoni, Sinéad O'Carroll, Chryssostomos Chatgilialoglu, Suainibhe Kelly, Anna Banasiak, Martin Clynes, Georgia Menounou, Andrew Kellett, George Mitrikas, Sandra Roche, Vickie McKee, Marios G. Krokidis, Zara Molphy

Publikováno v: Fantoni, N Z, Molphy, Z, O'Carroll, S, Menounou, G, Mitrikas, G, Krokidis, M G, Chatgilialoglu, C, Colleran, J, Banasiak, A, Clynes, M, Roche, S, Kelly, S, McKee, V & Kellett, A 2021, ' Polypyridyl-Based Copper Phenanthrene Complexes : Combining Stability with Enhanced DNA Recognition ', Chemistry-A European Journal, vol. 27, no. 3, pp. 971-983 . https://doi.org/10.1002/chem.202001996

We report a series of copper(II) artificial metallo-nucleases (AMNs) and demonstrate their DNA damaging properties and in-vitro cytotoxicity against human-derived pancreatic cancer cells. The compounds combine a tris-chelating polypyridyl ligand, di-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a429f0b85d62025e480930b686f3e22
https://pubmed.ncbi.nlm.nih.gov/32519773