Effects of the ACE2-Ang-(1-7)-Mas axis on gut flora diversity and intestinal metabolites in SuHx mice

Autor: Asimuguli Abudukeremu, Ainiwaer Aikemu, Tao Yang, Lei Fang, Adilai Aihemaitituoheti, Yupeng Zhang, Daliya Shanahaiti, Yiliyaer Nijiati

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

ObjectivePulmonary artery hypertension (PAH) poses a significant challenge due to its limited therapeutic options and high mortality rates. The ACE2-Ang-(1-7)-Mas axis plays a pivotal role in regulating blood pressure and inhibiting myocardial remode

Externí odkaz: https://doaj.org/article/e5fc6f8a735d44a48fcb23c175f11c7f

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Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Autor: Ly Tu, Frances S. de Man, Harm Jan Bogaard, Raphaël Thuillet, Julian F. R. Paton, M. Louis Handoko, Anton Vonk-Noordegraaf, Christophe Guignabert, Ingrid Schalij, Denielli da Silva Goncalves Bos, Chris Happé, Wioletta Pijacka, Albert C. van Rossum

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 1, Pp 22-35 (2017)
Jacc. Basic to Translational Science
da Silva Gonçalves Bos, D, Happé, C, Schalij, I, Pijacka, W, Paton, J F R, Guignabert, C, Tu, L, Thuillet, R, Bogaard, H J, van Rossum, A C, Vonk-Noordegraaf, A, de Man, F S & Handoko, M L 2017, ' Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension ', JACC: Basic to Translational Science, vol. 2, no. 1, pp. 22-35 . https://doi.org/10.1016/j.jacbts.2016.09.007
da Silva Gonçalves Bos, D, Happé, C, Schalij, I, Pijacka, W, Paton, J F R, Guignabert, C, Tu, L, Thuillet, R, Bogaard, H-J, van Rossum, A C, Vonk-Noordegraaf, A, de Man, F S & Handoko, M L 2017, ' Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension ', JACC: Basic to Translational Science, vol. 2, no. 1, pp. 22–35 . https://doi.org/10.1016/j.jacbts.2016.09.007
JACC: Basic to Translational Science, 2(1), 22-35. Elsevier Inc.

Visual Abstract
Highlights • Neurohormonal dysfunction (increased sympathetic nervous system and renin angiotensin-aldosterone system) play an important role in pulmonary hypertension progression. • In this proof-of-concept study we demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59b7f95f7fec99ad60098c33515947c
http://www.sciencedirect.com/science/article/pii/S2452302X16301668

Novel Therapeutic Strategies for the Treatment of Pulmonary Arterial Hypertension

Autor: Suen, Colin

Pulmonary arterial hypertension (PAH) is a progressive disease that results in increased pulmonary vasculature resistance, causing right ventricular (RV) remodeling, which eventually progresses into right heart failure and mortality. New and emerging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::739d2c5c2c368a38b82bea38ab61bc0d

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension.

Autor: da Silva Gonçalves Bos D; Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.; Department of Physiology VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., Happé C; Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.; Department of Physiology VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., Schalij I; Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.; Department of Physiology VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., Pijacka W; School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, United Kingdom., Paton JFR; School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, United Kingdom., Guignabert C; University of Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France.; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France., Tu L; University of Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France.; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France., Thuillet R; University of Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France.; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France., Bogaard HJ; Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., van Rossum AC; Department of Cardiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., Vonk-Noordegraaf A; Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., de Man FS; Department of Pulmonology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.; Department of Physiology VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands., Handoko ML; Department of Physiology VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.; Department of Cardiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, the Netherlands.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2017 Feb 01; Vol. 2 (1), pp. 22-35. Date of Electronic Publication: 2017 Feb 01 (Print Publication: 2017).