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Knockout of CNR1 prevents metabolic stress-induced cardiac injury through improving insulin resistance (IR) injury and endoplasmic reticulum (ER) stress by promoting AMPK-alpha activation

Autor: Su-Juan Pei, Jinhui Guo, Xin Zhang, Huai-Yuan Zhu, Zhi-Jian Deng

Publikováno v: Biochemical and Biophysical Research Communications. 503:744-751

Obesity and diabetes are associated with diabetic cardiomyopathy (DCM). However, the pathogenesis of DCM is not fully understood. Cannabinoid receptor gene (CNR1) has been a drug target for the treatment of obesity. Here, we reported that CNR1 expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bff970830c0c95f761d8a14a6909b8
https://doi.org/10.1016/j.bbrc.2018.06.070

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Ginsenoside compound K promotes β-amyloid peptide clearance in primary astrocytes via autophagy enhancement

Autor: Meishuang Yu, Li Chang, Jinhui Guo, Su-Juan Pei, Xin Zhang, Gao Jianlian

Publikováno v: Experimental and Therapeutic Medicine

The aim of the present study was to investigate the effect of ginsenoside compound K on β-amyloid (Aβ) peptide clearance in primary astrocytes. Aβ degradation in primary astrocytes was determined using an intracellular Aβ clearance assay. Aggrega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d9ed840a9a89085c0c4add631f89bb
http://europepmc.org/articles/PMC4151796

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