Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Su-Chun Zhang"'
Publikováno v:
Advanced Science, Vol 10, Iss 33, Pp n/a-n/a (2023)
Abstract There is no effective therapy for ischemic stroke following the acute stage. Neural transplantation offers a potential option for repairing the ischemic lesion. However, this strategy is hindered by the poor survival of the neural precursor
Externí odkaz:
https://doaj.org/article/d852241e184b4072818f59461b3f53f7
Autor:
Dinesh Upadhya, Sahithi Attaluri, Yan Liu, Bharathi Hattiangady, Olagide W. Castro, Bing Shuai, Yi Dong, Su-Chun Zhang, Ashok K. Shetty
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract Interneuron loss/dysfunction contributes to spontaneous recurrent seizures (SRS) in chronic temporal lobe epilepsy (TLE), and interneuron grafting into the epileptic hippocampus reduces SRS and improves cognitive function. This study investi
Externí odkaz:
https://doaj.org/article/a46dd92bccba4268a9926f9aa3052784
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-6 (2022)
Abstract Parkinson’s disease (PD) may optimally be treated with a disease-modifying therapy to slow progression. We compare data underlying surgical approaches proposed to impart disease modification in PD: (1) cell transplantation therapy with ste
Externí odkaz:
https://doaj.org/article/fb91da2a1eee42928b8c6d43c1fb7ecd
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/63d01cf542b645e4aa1c0b25cba44586
Autor:
Yongchao Mou, Yi Dong, Zhenyu Chen, Kyle R. Denton, Michael O. Duff, Craig Blackstone, Su-Chun Zhang, Xue-Jun Li
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Hereditary spastic paraplegias (HSPs) are caused by a length-dependent axonopathy of long corticospinal neurons, but how axons of these cortical projection neurons (PNs) degenerate remains elusive. We generated isogenic human pluripotent ste
Externí odkaz:
https://doaj.org/article/2f4a0eef358e44248cac7d0af78e78cc
Autor:
Matthew Zammit, Yunlong Tao, Miles E. Olsen, Jeanette Metzger, Scott C. Vermilyea, Kathryn Bjornson, Maxim Slesarev, Walter F. Block, Kerri Fuchs, Sean Phillips, Viktorya Bondarenko, Su-Chun Zhang, Marina E. Emborg, Bradley T. Christian
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Purpose The aim of this study was to examine whether the translocator protein 18-kDa (TSPO) PET ligand [18F]FEPPA has the sensitivity for detecting changes in CD68-positive microglial/macrophage activation in hemiparkinsonian rhesus macaques
Externí odkaz:
https://doaj.org/article/3a4316aa216e4d56b002e6457eab6e77
Autor:
ChenZi Gong, Xiaolong Zheng, FangLiang Guo, YaNan Wang, Song Zhang, Jing Chen, XueJiao Sun, Sayed Zulfiqar Ali Shah, YiFeng Zheng, Xiao Li, Yatao Yin, Qian Li, XiaoLin Huang, Tiecheng Guo, Xiaohua Han, Su-Chun Zhang, Wei Wang, Hong Chen
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108889- (2021)
Summary: Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem cells from spinal GABA neurons. After transplantatio
Externí odkaz:
https://doaj.org/article/3f1dc27dac7446c583298a605e66d660
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: Long-term potentiation and depression, inferred from analysis on brain slices, are considered the cellular processes underlying learning and memory formation. They have not so far been demonstrated in human stem cell-derived neurons. By expr
Externí odkaz:
https://doaj.org/article/2cb4ddaf8d744569b9d54b202978e0b1
Autor:
Xiang Li, Yezheng Tao, Robert Bradley, Zhongwei Du, Yunlong Tao, Linghai Kong, Yi Dong, Jeffrey Jones, Yuanwei Yan, Cole R.K. Harder, Lindsay Morgan Friedman, Magd Bilal, Brianna Hoffmann, Su-Chun Zhang
Publikováno v:
Stem Cell Reports, Vol 11, Iss 4, Pp 998-1008 (2018)
Summary: Differentiation of astrocytes from human pluripotent stem cells (hPSCs) is a tedious and variable process. This hampers the study of hPSC-generated astrocytes in disease processes and drug development. By using CRISPR/Cas9-mediated inducible
Externí odkaz:
https://doaj.org/article/d7a591da868c47328917641f6b3c6cda
Autor:
Liqun Wang, Jing Xia, Jonathan Li, Tracy L. Hagemann, Jeffrey R. Jones, Ernest Fraenkel, David A. Weitz, Su-Chun Zhang, Albee Messing, Mel B. Feany
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Alexander disease is a rare neurodegeneration caused by mutations in a glial gene GFAP. Here, Wang and colleagues show in animal models of Alexander disease that GFAP mutant brain and cells have greater tissue and cellular stiffness and greater activ
Externí odkaz:
https://doaj.org/article/36c12df858ac434183e838e24dc960c5